Controlled Nitric Oxide Delivery Platform Based on S-Nitrosothiol Conjugated Interpolymer Complexes for Diabetic Wound Healing

2010 ◽  
Vol 7 (1) ◽  
pp. 254-266 ◽  
Author(s):  
Yan Li ◽  
Ping I. Lee
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Interpolymer Complexes ◽  
Delivery Platform ◽  
Diabetic Wound Healing ◽  
Nitric Oxide Delivery

scholarly journals Nitric Oxide Therapy for Diabetic Wound Healing

2019 ◽  
Vol 8 (12) ◽  
pp. 1801210 ◽  
Author(s):  
Maggie J. Malone‐Povolny ◽  
Sara E. Maloney ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Nitric Oxide Therapy

scholarly journals Aloe Gel Enhances Angiogenesis in Healing of Diabetic Wound

2011 ◽  
Vol 3 (3) ◽  
pp. 204
Author(s):  
Djanggan Sargowo ◽  
Adeodatus Yuda Handaya ◽  
Mohammad Aris Widodo ◽  
Diana Lyrawati ◽  
Askandar Tjokroprawiro
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Wistar Rats ◽  
Aloe Vera ◽  
Diabetic Rats ◽  
Diabetic Wound ◽  
Aloe Vera Gel ◽  
Diabetic Wound Healing ◽  
Aloe Gel ◽  
Oxide Synthase

BACKGROUND: Diabetic micro and macroangiophathy lead to the incident of diabetic foot ulcers characterized by an increased number of circulating endothelial cells (CECs) and decreased function of endothelial progenitor cells (EPCs). This fact is correlated with ischemia and diabetic wound healing failure. Aloe vera gel is known to be able to stimulate vascular endothelial growth factor (VEGF) expression and activity by enhancing nitric oxide (NO) production as a result of nitric oxide synthase (NOS) enzyme activity. Aloe vera is a potential target to enhancing angiogenesis in wound healing.OBJECTIVE: The objective of this study was to explore the major role of Aloe vera gel in wound healing of diabetic ulcers by increasing the level of EPCs, VEGF, and endothelial nitric oxide synthase (eNOS), as well as by reducing the level of CECs involved in angiogenesis process of diabetic ulcers healing.METHODS: The experimental groups was divided into five subgroups consisting of non diabetic wistar rats, diabetic rats without oral administration of aloe gel, and treatment subgroup (diabetic rats) with 30, 60 and 120 mg/day of aloe gel doses for 14 days. All subgroups were wounded and daily observation was done on the wounds areas. Measurement of the number of EPCs (CD34), and CECs (CD45 and CD146) was done by flowcytometry, followed by measurement of VEGF and eNOS expression on dermal tissue by immunohistochemical method on day 0 and day 14 after treatment. The quantitative data were analyzed by One-Way ANOVA and Linear Regression, with a cofidence interval 5% and significance level (p<0.05) using SPSS 16 software to compare the difference and correlation between wound diameters, number of EPCs and CECs as well as the levels of VEGF and eNOS.RESULTS: The results of this study showed that aloe gel oral treatment in diabetic wistar rats was able to accelerate the wound healing process. It was shown by significant reduction of wound diameter (0.27±0.02); the increased number of CECs (0.42±0.57), respectively (p<0.05). On the other hand, the wound diameter and eNOS indicators showed significant differences at the dose of 60 mg, while the number of EPCs and CECs and the level of VEGF showed significantly different results at a dose of 120 mg. Aloe gel oral therapy showed a positive indication of wound healing acceleration at the optimum dose range 60-120 mg a day.CONCLUSIONS: Aloe gel is potential to be a herbal therapy candidate for diabetic wound healing through enhancing EPCs homing, decreasing the CECs number, and stimulating the increase of VEGF and eNOS levels,hence proving to be a dominant factor in the angiogenesis process.KEYWORDS: aloe gel, diabetes, wound healing, angiogenesis

scholarly journals Therapeutic Role of Nitric Oxide in Diabetic Wound Healing: A Systematic Review

2021 ◽  
pp. 68-80
Author(s):  
Mayur Meghashyam Chavhan ◽  
Ranjit Vinayak Gadhave ◽  
Yogita Sachin Ozarde ◽  
Ganesh Bhaurao Choudhari
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Bacterial Infections ◽  
The Body ◽  
Low Level Laser Therapy ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Impaired Wound Healing ◽  
Diabetic Wound Healing

Post injury, healing of wound is essential for recovery of uprightness of the body, which is one of the complex, continuous and unanticipated chains of events in case of diabetic patients. Nitric oxide represents a potential wound therapeutic agent due to its ability to regulate inflammation and eradicate bacterial infections. Impaired wound healing is a prominent diabetic complication which may lead to amputations also. In addition to modern medicines we can use nitric oxide therapy prominently for diabetic wound healing. Prominent and proven role of nitric oxide as well as conventional materials (like metformin and hydrogen sulphide, whey proteins, acidified nitrile etc), therapies (like low level laser therapy, hyperbaric oxygen therapy etc) and techniques (like in vivo implants with biosensors) can be taken into consideration. Many plant extracts showed promising results for wound healing activity by increasing nitric oxide levels. Use of modern technologies such as implant with biosensor and technique like sonic head hog gene are available for diabetic wound healing using Nitric oxide. In this review, an attempt has been made to compile comprehensive updated information of role of nitric oxide in diabetic wound healing, which may be exploited by focusing more on development of effective strategies to treat diabetes-associated wound.

Copper-Based Metal–Organic Framework as a Controllable Nitric Oxide-Releasing Vehicle for Enhanced Diabetic Wound Healing

2020 ◽  
Vol 12 (16) ◽  
pp. 18319-18331 ◽  
Author(s):  
Pengju Zhang ◽  
You Li ◽  
Yaohui Tang ◽  
Hui Shen ◽  
Jiankai Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Metal Organic Framework ◽  
Diabetic Wound ◽  
Metal Organic ◽  
Diabetic Wound Healing ◽  
Nitric Oxide Releasing ◽  
Organic Framework

L-Arginine supplementation enhances diabetic wound healing: Involvement of the nitric oxide synthase and arginase pathways

Metabolism ◽  
2002 ◽  
Vol 51 (10) ◽  
pp. 1269-1273 ◽  
Author(s):  
Maria B. Witte ◽  
Frank J. Thornton ◽  
Udaya Tantry ◽  
Adrian Barbul
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Nitric Oxide Synthase ◽  
Diabetic Wound ◽  
Diabetic Wound Healing ◽  
Oxide Synthase ◽  
Arginine Supplementation

The diabetic wound healing effect of a two-herb formula and its mechanisms of action

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
CBS Lau ◽  
VKM Lau ◽  
CL Liu ◽  
PKK Lai ◽  
JCW Tam ◽  
...  
Keyword(s):  
Wound Healing ◽  
Mechanisms Of Action ◽  
Diabetic Wound ◽  
Healing Effect ◽  
Diabetic Wound Healing ◽  
Wound Healing Effect
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