Research Profile: Digging for disease markers of sepsis

Ubiquitination and deubiquitination are protein post-translational modification processes that have been recognized as crucial mediators of many complex cellular networks, including maintaining ubiquitin homeostasis, controlling protein stability, and regulating several signaling pathways. Therefore, some of the enzymes involved in ubiquitination and deubiquitination, particularly E3 ligases and deubiquitinases, have attracted attention for drug discovery. Here, we review recent findings on USP15, one of the deubiquitinases, which regulates diverse signaling pathways by deubiquitinating vital target proteins. Even though several basic previous studies have uncovered the versatile roles of USP15 in different signaling networks, those have not yet been systematically and specifically reviewed, which can provide important information about possible disease markers and clinical applications. This review will provide a comprehensive overview of our current understanding of the regulatory mechanisms of USP15 on different signaling pathways for which dynamic reverse ubiquitination is a key regulator.

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Is there an imbalance in the supply and demand for universal accessibility knowledge? Twenty years of UAIS papers viewed through the lens of WCAG

Universal Access in the Information Society ◽

10.1007/s10209-021-00834-y ◽

2021 ◽

Author(s):

Frode Eika Sandnes

Keyword(s):

Latin America ◽

North America ◽

Supply And Demand ◽

Research Focus ◽

Universal Accessibility ◽

Geographical Regions ◽

Research Profile ◽

The Impact ◽

Over Time

AbstractPurpose: Some universal accessibility practitioners have voiced that they experience a mismatch in the research focus and the need for knowledge within specialized problem domains. This study thus set out to identify the balance of research into the main areas of accessibility, the impact of this research, and how the research profile varies over time and across geographical regions. Method: All UAIS papers indexed in Scopus were analysed using bibliometric methods. The WCAG taxonomy of accessibility was used for the analysis, namely perceivable, operable, and understandable. Results: The results confirm the expectation that research into visual impairment has received more attention than papers addressing operable and understandable. Although papers focussing on understandable made up the smallest group, papers in this group attracted more citations. Funded research attracted fewer citations than research without funding. The breakdown of research efforts appears consistent over time and across different geographical regions. Researchers in Europe and North America have been active throughout the last two decades, while Southeast Asia, Latin America, and Middle East became active in during the last five years. There is also seemingly a growing trend of out-of-scope papers. Conclusions: Based on the findings, several recommendations are proposed to the UAIS editorial board.

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Streptococcal infection and renal disease markers in Australian Aboriginal children

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1992.tb121414.x ◽

1992 ◽

Vol 156 (8) ◽

pp. 537-540 ◽

Cited By ~ 40

Author(s):

Paul G Van Buynder ◽

Julie A Gaggir ◽

Diana Martin ◽

David J Pugsley ◽

John D Mathews ◽

...

Keyword(s):

Renal Disease ◽

Streptococcal Infection ◽

Australian Aboriginal ◽

Disease Markers ◽

Aboriginal Children

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Dissecting the Interplay Mechanism between Epigenetics and Gut Microbiota: Health Maintenance and Disease Prevention

International Journal of Molecular Sciences ◽

10.3390/ijms22136933 ◽

2021 ◽

Vol 22 (13) ◽

pp. 6933

Author(s):

Yuqi Wu ◽

Chong-Zhi Wang ◽

Jin-Yi Wan ◽

Haiqiang Yao ◽

Chun-Su Yuan

Keyword(s):

Disease Prevention ◽

Gut Microbiota ◽

Intestinal Inflammation ◽

Epigenetic Factors ◽

Metabolic Disturbances ◽

Health Maintenance ◽

Full Life Cycle ◽

Research Profile ◽

Health And Disease ◽

New Perspective

The gut microbiota exists throughout the full life cycle of the human body, and it has been proven to have extensive impacts on health and disease. Accumulating evidence demonstrates that the interplay between gut microbiota and host epigenetics plays a multifaceted role in health maintenance and disease prevention. Intestinal microflora, along with their metabolites, could regulate multiple epigenetic pathways; e.g., DNA methylation, miRNA, or histone modification. Moreover, epigenetic factors can serve as mediators to coordinate gut microbiota within the host. Aiming to dissect this interplay mechanism, the present review summarizes the research profile of gut microbiota and epigenetics in detail, and further interprets the biofunctions of this interplay, especially the regulation of intestinal inflammation, the improvement of metabolic disturbances, and the inhibition of colitis events. This review provides new insights into the interplay of epigenetics and gut microbiota, and attempts to reveal the mysteries of health maintenance and disease prevention from this new perspective.

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