Transcriptomic Analysis Reveals Early Signs of Liver Toxicity in Female MRL +/+ Mice Exposed to the Acylating Chemicals Dichloroacetyl Chloride and Dichloroacetic Anhydride

2008 ◽  
Vol 21 (3) ◽  
pp. 572-582 ◽  
Author(s):  
Rolf König ◽  
Ping Cai ◽  
Xin Guo ◽  
G. A. S. Ansari
Keyword(s):  
Liver Toxicity ◽  
Transcriptomic Analysis ◽  
Early Signs ◽  
Dichloroacetyl Chloride

Changes in Gut Microbiota May Be Early Signs of Liver Toxicity Induced by Epoxiconazole in Rats

Chemotherapy ◽  
2014 ◽  
Vol 60 (2) ◽  
pp. 135-142 ◽  
Author(s):  
Cheng Xu ◽  
Qian Liu ◽  
Fei Huan ◽  
Jianhua Qu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Liver Toxicity ◽  
Early Signs

Early signs of congenital dislocation of the hip

JAMA ◽  
1966 ◽  
Vol 195 (1) ◽  
pp. 47-48
Author(s):  
A. L. Matles
Keyword(s):  
Congenital Dislocation ◽  
Early Signs ◽  
Dislocation Of The Hip

Prolonged Fixation Studies For Spaceflight

1973 ◽  
Vol 31 ◽  
pp. 332-333
Author(s):  
Robert Corbett ◽  
Delbert E. Philpott ◽  
Sam Black
Keyword(s):  
High Pressure ◽  
Living Systems ◽  
Prolonged Storage ◽  
Time Intervals ◽  
Early Signs ◽  
Large Numbers

Observation of subtle or early signs of change in spaceflight induced alterations on living systems require precise methods of sampling. In-flight analysis would be preferable but constraints of time, equipment, personnel and cost dictate the necessity for prolonged storage before retrieval. Because of this, various tissues have been stored in fixatives and combinations of fixatives and observed at various time intervals. High pressure and the effect of buffer alone have also been tried.Of the various tissues embedded, muscle, cartilage and liver, liver has been the most extensively studied because it contains large numbers of organelles common to all tissues (Fig. 1).

Isoniazid chemoprophylaxis. Association with detection and incidence of liver toxicity

1977 ◽  
Vol 137 (9) ◽  
pp. 1130-1133 ◽  
Author(s):  
R. B. Byrd
Keyword(s):  
Liver Toxicity

Observation List of Possible Early Signs of Dementia--Short Version

2001 ◽  
Author(s):  
Marijke Hopman-Rock ◽  
Erwin C. P. M. Tak ◽  
Patricia G. M. Staats
Keyword(s):  
Short Version ◽  
Early Signs

A possible association between genotypes and early signs of Rett disorder

2008 ◽  
Vol 39 (05) ◽  
Author(s):  
C Einspieler ◽  
PB Marschik ◽  
AM Kerr ◽  
A Oberle ◽  
HFR Prechtl
Keyword(s):  
Early Signs

Hepatoprotective activity of the wild carrot chloroform-based fraction against CCl4-induced liver toxicity in mice

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
W Shebaby ◽  
M El-Sibai ◽  
M Mroueh ◽  
K Bodman-Smith ◽  
R Taleb ◽  
...  
Keyword(s):  
Liver Toxicity ◽  
Hepatoprotective Activity ◽  
Wild Carrot

Potential Liver Toxicity of X54 is Educed Under Pre-existing Inflammatory Conditions in a Murine Model

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
MA Hammad ◽  
MK Ashfaq ◽  
LA Walker
Keyword(s):  
Murine Model ◽  
Liver Toxicity ◽  
Inflammatory Conditions

Down regulation of COX-2, IL-1β, TNF-α in cynoviocyte by essential oil of Fraxinus excelsior

2018 ◽  
Vol 9 (03) ◽  
pp. 20192-20203
Author(s):  
Dr Maghsoudi, Hossein ◽  
Samaneh Haj-allahyari
Keyword(s):  
Liver Toxicity ◽  
Rna Extraction ◽  
Current Treatment ◽  
Fraxinus Excelsior ◽  
Peptic Ulcers ◽  
Down Regulation ◽  
Bovine Articular Cartilage ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Cox 2

Osteoarthritis (arthritis) is biomechanical, biochemical and cellular phenomenon, and is not known as a degenerative disease. Arthritis is one of the common chronic diseases and the most important reason of physical disability in the world. According to its side effect such as peptic ulcers, gastrointestinal bleeding, liver toxicity and renal complications dueofprescribing current treatment contain corticosteroid and non-steroidal, we decided to evaluate possible effect of anti-inflammatory Esential oil of Fraxinus excelsior (EOFE) on biomarkers involved in disease. EOFE were prepared of genetic resources center. Bovine  articular cartilage derived from the metacarpophalangeal joints of 14–18-month-old animals (without any sign of inflammation and bleeding) sent to laboratory in sterile bags at 4ºC. Cells were cultured in appropriate condition and counted by hemocytometer, viability assessed by trypan blue. After LPS treatment, cytokine levels were assayed. Cells cultures again and were kept in 37C, 90% humidity in CO2 incubator and after RNA extraction, RT-PCR and PCR done. Also by Real-time PCR, gene expression was evaluated. E.E.F.E level cause down regulation of COX-2, IL-1β, TNF-α in LPS-stimulated cells.

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