Staged ultrasound-guided liposuction for hidden arteriovenous fistulas in obese patients

VASA ◽  
2018 ◽  
Vol 47 (5) ◽  
pp. 403-407
Author(s):  
Gabor Cs.Nagy ◽  
Reiner Verwiebe ◽  
Matthias Wunsch

Abstract. Background: In obese patients with end stage renal disease, puncturing matured arteriovenous fistulas (AVF) that run deep under the skin surface may prove difficult. To achieve reliable puncturability, there are several surgical solutions. Superficialization with mobilization is common. With some newer options (lipectomy and liposuction) subcutaneous adipose tissue is surgically reduced. There are only a few authors who have published their experience with liposuction and we want to add our own results. Patients and methods: We report our experience with ultrasound-guided liposuction (USGL). We introduce liposuction cannulas via small incisions to reduce the subcutaneous adipose tissue overlying the planned cannulation zones under ultrasound control using tumescent anaesthesia till the prospective needle access segments become easily palpable. So far, we have used this technique for cephalic forearm and upper arm fistulas only. Furthermore, we review the relevant literature. Results: From February 2014 through November 2016, six patients were treated using USGL. Their body mass indices ranged from 30.8 to 53.8 kg/m2 (mean 37.6). The mean depths of the AVFs beneath the skin surface were 13.3 (8–20) mm before and 5.1 (3.5–6) mm after surgery. The mean time of the procedure was 15 minutes. There were no postoperative complications. In five patients, the AVFs could reliably be punctured after three weeks. One patient is not yet on dialysis. During the follow-up period of 24 (11–43) months, all six AVFs remained primarily patent. In the literature, we found nine reports on altogether 81 patients undergoing USGL. Almost all noteworthy complications occurred only after ultrasound-powered liquefaction of adipose tissue, which was only used by a single investigator. Conclusions: USGL is a method that can be learned easily, is minimally invasive, seems to be safe, and requires only short operation times.

1986 ◽  
Vol 20 (11) ◽  
pp. 869-873 ◽  
Author(s):  
Henry J. Mann ◽  
Henry Buchwald

Distribution and elimination of cefamandole 2 g iv were studied in 11 morbidly obese patients during a gastric bypass operation and again on the first postoperative day. Serum, subcutaneous adipose tissue, wound drainage, and urine were analyzed by high performance liquid chromatography for cefamandole and pharmacokinetic parameters from the intraoperative period were compared to those obtained postoperatively. Total body clearance was significantly greater (p < 0.001) postoperatively (297 ml/min) than intraoperatively (254 ml/min). Volume changes were unpredictable but the elimination rate constant tended to increase postoperatively. Renal clearance and percentage of urinary recovery were significantly increased (p < 0.01) postoperatively. The patients had a mean (± SD) volume of the central compartment of 10.3 (± 2.3) L, volume at steady state of 18.3 (± 3.9) L, and elimination rate constant of 1.67 (± 0.63) h−1. Tissue concentrations of cefamandole were highest during the first hour after drug administration and were < 1 μg/g after 3.5 hours. Mean wound drainage concentrations ranged between 10 and 12 μg/ml during a dosing interval and dropped to 7 μg/ml 12 hours after the last dose. Intraoperative dosing of cefamandole is required to maintain subcutaneous adipose tissue concentrations > 1 μg/g during procedures longer than three hours in morbidly obese patients. A postoperative dose of cefamandole 2 g iv q6h will provide sustained and therapeutic concentrations in the wound drainage of morbidly obese patients.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2313-PUB
Author(s):  
IURII STAFEEV ◽  
IGOR SKLYANIK ◽  
SVETLANA MICHURINA ◽  
EKATERINA SHESTAKOVA ◽  
ANATOLIY YURASOV ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Carmela Nardelli ◽  
Laura Iaffaldano ◽  
Vincenzo Pilone ◽  
Giuseppe Labruna ◽  
Maddalena Ferrigno ◽  
...  

Background. Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients. To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women. Case Reports. SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0. Bioinformatics predicted that these miRNAs regulate genes belonging to pathways associated with the cytoskeleton, inflammation, and metabolism. Western blot analysis showed that PPAR-alpha, which is the target gene of miR-519d, increased after LAGB, thereby suggesting an improvement in SAT lipid metabolism. Accordingly, the number and diameter of adipocytes were significantly higher and lower, respectively, at T1 versus T0. Bioinformatics predicted that the decreased levels of miR-212, miR-299-5p, and miR-671-3p at T1 concur in reducing SAT inflammation. Conclusion. We show that the miRNA profile changes after LAGB. This finding, although obtained in only three cases, suggests that this epigenetic mechanism, by regulating the expression of genes involved in inflammation and lipid metabolism, could concur to improve SAT functionality in postoperative obese patients.


Obesity ◽  
2006 ◽  
Vol 14 (5) ◽  
pp. 794-798 ◽  
Author(s):  
Raoul Desbriere ◽  
Vincent Vuaroqueaux ◽  
Vincent Achard ◽  
Sandrine Boullu-Ciocca ◽  
Martin Labuhn ◽  
...  

2016 ◽  
Vol 73 ◽  
pp. 53-59 ◽  
Author(s):  
Fusun Ozmen ◽  
M. Mahir Ozmen ◽  
Sibel Gelecek ◽  
İsmail Bilgic ◽  
Munevver Moran ◽  
...  

2017 ◽  
Vol 36 ◽  
pp. S38
Author(s):  
P. Noirez ◽  
A. Meziani ◽  
M. Dulac ◽  
G. El Hajj Boutros ◽  
V. Marcangeli ◽  
...  

2012 ◽  
Vol 26 (10) ◽  
pp. 4327-4336 ◽  
Author(s):  
Blanca Oñate ◽  
Gemma Vilahur ◽  
Raquel Ferrer‐Lorente ◽  
Juan Ybarra ◽  
Alberto Díez‐Caballero ◽  
...  

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