The production of cereals, tubers, and vegetables largely depends on the application of organic and inorganic fertilizers to offset their nutrients requirement. In this chapter, the authors identify different soil fertility management practices the maize farmers are using and examine the economic benefits of such practices in maize production. To complete the study, 237 maize farmers across Kogi and Kwara States, Nigeria were investigated. Descriptive statistics, gross margin, and multinomial logit tools were used to analyze the data. The results show that majority of the maize farmers (41.40%) use only inorganic material. Labour employed in the application of fertility materials, distance to the source of fertility materials, the quantity of seed planted, educational attainment, and gender of the maize farmer were the determinants of the use of fertility management practices relative to integrated soil fertility management (ISFM). The analyses of the results show that the use of ISFM for maize production is the most profitable method with a profitability ratio of 2.29.