Human Papilloma Virus (HPV)-E6/E7 and Epidermal Growth Factor Receptor (EGF-R) Protein Levels in Cervical Cancer and Cervical Intraepithelial Neoplasia (CIN)

2001 ◽  
Vol 46 (4) ◽  
pp. 280-287 ◽  
Author(s):  
SUBBI P. MATHUR ◽  
RAJESH S. MATHUR ◽  
ROGER C. YOUNG ◽  
PHILIP F. RUST
Keyword(s):  
Cervical Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Intraepithelial Neoplasia ◽  
Papilloma Virus ◽  
Protein Levels ◽  
Hpv E6 ◽  
Epidermal Growth

scholarly journals Molecular mechanisms of epidermal growth factor receptor overexpression in patients with cervical cancer

2011 ◽  
Vol 24 (5) ◽  
pp. 720-728 ◽  
Author(s):  
Marlies Schrevel ◽  
Arko Gorter ◽  
Sandra M Kolkman-Uljee ◽  
J Baptist M Z Trimbos ◽  
Gert Jan Fleuren ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Molecular Mechanisms ◽  
Growth Factor Receptor ◽  
Epidermal Growth

Expression and Tyrosine Phosphorylation of E-Cadherin, β- and γ-Catenin, and Epidermal Growth Factor Receptor in Cervical Cancer Cells

2001 ◽  
Vol 81 (3) ◽  
pp. 355-359 ◽  
Author(s):  
Hye-Sung Moon ◽  
Eun-Ah Choi ◽  
Hae-Young Park ◽  
Jung-Youn Choi ◽  
Hye-Won Chung ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Cells ◽  
Tyrosine Phosphorylation ◽  
Growth Factor Receptor ◽  
Cervical Cancer Cells ◽  
Epidermal Growth ◽  
E Cadherin

Nuclear Y-box binding protein-1 expression as a prognostic marker and correlation with epidermal growth factor receptor expression in cervical cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5085-5085
Author(s):  
Shin Nishio ◽  
Kimio Ushijima ◽  
Shuji Takemoto ◽  
Yuko Sasajima ◽  
Hitoshi Tsuda ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Her2 Expression ◽  
Stromal Invasion ◽  
Egfr Expression ◽  
Epidermal Growth ◽  
Poor Outcomes

5085 Background: Y-box binding protein-1 (YB-1) is a member of the cold shock protein family and functions in transcription and translation. Many reports indicate that YB-1 is highly expressed in tumor cells and is a marker of tumor aggressiveness and clinical prognosis. Overexpression of epidermal growth factor receptor (EGFR) has been associated with poor outcomes in cervical cancer (CC). Clinical trials have shown that EGFR inhibitors are effective against CC (JCO 2011). Nuclear YB-1 expression correlates with EGFR expression in various types of cancer. Methods: Nuclear YB-1 expression was immunohistochemically analyzed in tissue specimens obtained from 204 CC patients who underwent surgery. Associations of nuclear YB-1 expression with clinicopathological factors such as survival and EGFR (HER1 and HER2) expression were investigated. Results: Nuclear YB-1 expression was observed in 41 (20%) of 204 cases and correlated with stage, tumor diameter, stromal invasion, and lymph-node metastasis. Nuclear YB-1 expression also correlated with both HER1 expression (p=0.0114) and HER2 expression (p=0.0053). Kaplan-Meier survival analysis showed that nuclear YB-1 expression was significantly associated with poor outcomes in terms of progression-free survival (p=0.0033) and overall survival (p=0.0003). On multivariate analysis, stromal invasion, parametrial invasion, and nuclear YB-1 expression were independent predictors of survival. Conclusions: Nuclear YB-1 expression is a prognostic marker and correlates with EGFR expression in CC.

Cyclooxygenase-2 protein levels are independent of epidermal growth factor receptor expression or activation in operable non-small cell lung cancer

Lung Cancer ◽  
2005 ◽  
Vol 48 (1) ◽  
pp. 47-57 ◽  
Author(s):  
C.M. Richardson ◽  
D. Richardson ◽  
D.E.B. Swinson ◽  
W.A. Swain ◽  
G. Cox ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Small Cell ◽  
Receptor Expression ◽  
Small Cell Lung ◽  
Protein Levels ◽  
Epidermal Growth
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