Supplemental Material for Longitudinal Stability of Cognitive Control in Early Psychosis: Nondegenerative Deficits Across Diagnoses

Abstract Psychotic illness is associated with cognitive control deficits and abnormal recruitment of neural circuits subserving cognitive control. It is unclear to what extent this dysfunction underlies the development and/or maintenance of positive and negative symptoms typically observed in schizophrenia. In this study we compared fMRI activation on a standard Stroop task and its relationship with positive and negative symptoms in early psychosis (EP, N = 88) and chronic schizophrenia (CHR-SZ, N = 38) patients. CHR-SZ patients showed reduced frontal, striatal, and parietal activation across incongruent and congruent trials compared to EP patients. Higher positive symptom severity was associated with reduced activation across both trial types in supplementary motor area (SMA), middle temporal gyrus and cerebellum in EP, but not CHR-SZ patients. Higher negative symptom severity was associated with reduced cerebellar activation in EP, but not in CHR-SZ patients. A negative correlation between negative symptoms and activation in SMA and precentral gyrus was observed in EP patients and in CHR-SZ patients. The results suggest that the neural substrate of positive symptoms changes with illness chronicity, and that cognitive control related neural circuits may be most relevant in the initial development phase of positive symptoms. These findings also highlight a changing role for the cerebellum in the development and later maintenance of both positive and negative symptoms.

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Sub-optimal modulation of gain by the cognitive control system in young adults with early psychosis

Translational Psychiatry ◽

10.1038/s41398-021-01673-4 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Bjorn Burgher ◽

Genevieve Whybird ◽

Nikitas Koussis ◽

James G. Scott ◽

Luca Cocchi ◽

...

Keyword(s):

Control System ◽

Cognitive Control ◽

Computational Models ◽

Effective Connectivity ◽

Group Versus ◽

Early Psychosis ◽

Control Group ◽

Structural Integration ◽

Indirect Path ◽

Nonlinear Modulation

AbstractExecutive dysfunctions in early psychosis (EP) are subtle but persistent, hindering recovery. We asked whether changes in the cognitive control system (CCS) disrupt the response to increased cognitive load in persons with EP. In all, 30 EP and 30 control participants undertook multimodal MRI. Computational models of structural and effective connectivity amongst regions in the CCS were informed by cortical responses to the multi-source interference task, a paradigm that selectively introduces stimulus conflict. EP participants showed greater activation of CCS regions, including the superior parietal cortex, and were disproportionately slower at resolving stimulus conflict in the task. Computational models of the effective connectivity underlying this behavioral response suggest that the normative (control) group resolved stimulus conflict through an efficient and direct modulation of gain between the visual cortex and the anterior insula (AI). In contrast, the EP group utilized an indirect path, with parallel and multi-region hops to resolve stimulus conflict at the AI. Individual differences in task performance were dependent on initial linear gain modulations in the EP group versus a single nonlinear modulation in the control group. Effective connectivity in the EP group was associated with reduced structural integration amongst those connections critical for task execution. CCS engagement during stimulus conflict is hampered in EP owing to inefficient use of higher-order network interactions, with high tonic gain impeding task-relevant (phasic) signal amplification.

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Cognitive control constrains memory attributions

Behavioral and Brain Sciences ◽

10.1017/s0140525x19001869 ◽

2019 ◽

Vol 42 ◽

Author(s):

Colleen M. Kelley ◽

Larry L. Jacoby

Keyword(s):

Alzheimer’S Disease ◽

Older Adults ◽

Alzheimer's Disease ◽

Traumatic Brain Injury ◽

Brain Injury ◽

Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

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Daily Experiences of Commuting Strain and Self-Control at Work and at Home

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000256 ◽

2020 ◽

Vol 19 (3) ◽

pp. 125-134

Author(s):

Bettina S. Wiese ◽

Olivia Chaillié ◽

Ruth Noppeney ◽

Anna M. Stertz

Keyword(s):

Cognitive Control ◽

Negative Emotions ◽

Emotional Stability ◽

Self Control ◽

Diary Data ◽

Daily Experiences ◽

At Home

Abstract. The study investigates how commuting strain affects daily self-control capacities at work and at home. Irritability (i.e., increased readiness to express negative emotions when facing frustration) and concentration (i.e., a cognitive control capacity that relies on attention) were used as indicators of (impaired) self-control. Based on 5-day diary data from N = 185 train commuters, we found that on days with a strenuous ride from home to work, commuters indicated higher irritability and lower concentration capacity at work. On days with higher strain during the work-to-home ride, commuters reported to be more irritable back home. Moreover, commuters with low emotional stability turned out to be more affected by commuting strain but only if considering self-control impairment at home.

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Do Young Children Modulate Their Cognitive Control?

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000320 ◽

2016 ◽

Vol 63 (2) ◽

pp. 117-126 ◽

Cited By ~ 19

Author(s):

Solène Ambrosi ◽

Patrick Lemaire ◽

Agnès Blaye

Keyword(s):

Young Children ◽

Cognitive Control ◽

Inhibitory Control ◽

Age Range ◽

Stroop Tasks ◽

And Task

Abstract. Dynamic, trial-by-trial modulations of inhibitory control are well documented in adults but rarely investigated in children. Here, we examined whether 5-to-7 year-old children, an age range when inhibitory control is still partially immature, achieve such modulations. Fifty three children took flanker, Simon, and Stroop tasks. Above and beyond classic congruency effects, the present results showed two crucial findings. First, we found evidence for sequential modulations of congruency effects in these young children in the three conflict tasks. Second, our results showed both task specificities and task commonalities. These findings in young children have important implications as they suggest that, to be modulated, inhibitory control does not require full maturation and that the precise pattern of trial-by-trial modulations may depend on the nature of conflict.

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A Bird in the Hand Isn’t Good for Long

Experimental Psychology (formerly Zeitschrift für Experimentelle Psychologie) ◽

10.1027/1618-3169/a000385 ◽

2018 ◽

Vol 65 (1) ◽

pp. 23-31 ◽

Cited By ~ 2

Author(s):

Stefan Scherbaum ◽

Simon Frisch ◽

Maja Dshemuchadse

Keyword(s):

Decision Making ◽

Cognitive Control ◽

The Other ◽

Decision Task ◽

Short Term ◽

Additional Time ◽

Control Processes ◽

Folk Wisdom ◽

Study Participants ◽

Insight Into

Abstract. Folk wisdom tells us that additional time to make a decision helps us to refrain from the first impulse to take the bird in the hand. However, the question why the time to decide plays an important role is still unanswered. Here we distinguish two explanations, one based on a bias in value accumulation that has to be overcome with time, the other based on cognitive control processes that need time to set in. In an intertemporal decision task, we use mouse tracking to study participants’ responses to options’ values and delays which were presented sequentially. We find that the information about options’ delays does indeed lead to an immediate bias that is controlled afterwards, matching the prediction of control processes needed to counter initial impulses. Hence, by using a dynamic measure, we provide insight into the processes underlying short-term oriented choices in intertemporal decision making.

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A Review of the Role of Cue Processing in Task Switching

Zeitschrift für Psychologie ◽

10.1027/2151-2604/a000125 ◽

2013 ◽

Vol 221 (1) ◽

pp. 5-14 ◽

Cited By ~ 28

Author(s):

Kerstin Jost ◽

Wouter De Baene ◽

Iring Koch ◽

Marcel Brass

Keyword(s):

Cognitive Control ◽

Task Switching ◽

Task Switch ◽

Task Set ◽

Switch Costs ◽

Set Switching ◽

Controversial Topic ◽

Cue Encoding ◽

Cue Processing

The role of cue processing has become a controversial topic in research on cognitive control using task-switching procedures. Some authors suggested a priming account to explain switch costs as a form of encoding benefit when the cue from the previous trial is repeated and hence challenged theories that attribute task-switch costs to task-set (re)configuration. A rich body of empirical evidence has evolved that indeed shows that cue-encoding repetition priming is an important component in task switching. However, these studies also demonstrate that there are usually substantial “true” task-switch costs. Here, we review this behavioral, electrophysiological, and brain imaging evidence. Moreover, we describe alternative approaches to the explicit task-cuing procedure, such as the usage of transition cues or the task-span procedure. In addition, we address issues related to the type of cue, such as cue transparency. We also discuss methodological and theoretical implications and argue that the explicit task-cuing procedure is suitable to address issues of cognitive control and task-set switching.

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