Allergic and Normal Males' Reactions to Interpersonal Problem Situations: The Adolescent Conflict Test

SummaryTo shed some light on the homeostatic regulation of plasma fibrinogen, metabolic studies were made in healthy females, and in normal, thyroidectomized, and thyroxine-treated rabbits. In females, compared with normal males, plasma fibrinogen concentration, plasma and interstitial fibrinogen decreased consequent to an increased fractional catabolic rate and a normal fibrinogen synthesis rate. The interstitial/plasma fibrinogen ratio remained unchanged. In normal rabbits, with increasing body weight fractional catabolic rate and catabolic rate decreased, while fibrinogen concentration and plasma fibrinogen remained constant owing to a simultaneous decrease in fibrinogen synthesis. In addition, fractional transcapillary transfer rate and transcapillary flux also decreased resulting in a shrinkage of interstitial fibrinogen. Thyroidectomy and thyroxine-injection markedly altered fibrinogen metabolism: thyroid hormone accelerated fibrinogen catabolism but also stimulated synthesis. The net result was an increase in plasma fibrinogen and fibrinogen concentration. The interstitial/plasma fibrinogen ratio decreased in thyroxine-treated, and increased in thyroidectomized animals. This study defines the variations of the fibrinogen system parameters in these physiologic and pathologic conditions, and illustrates some patterns of alterations in fibrinogen metabolism.

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INFLUENCE OF METYRAPONE ON PLASMA CONCENTRATIONS OF TESTOSTERONE AND ANDROSTENEDIONE IN MAN

Acta Endocrinologica ◽

10.1530/acta.0.0680576 ◽

1971 ◽

Vol 68 (3) ◽

pp. 576-584 ◽

Cited By ~ 5

Author(s):

K. O. Nilsson ◽

B. Hökfelt

Keyword(s):

Body Weight ◽

Male Patient ◽

Gradual Increase ◽

Plasma Concentrations ◽

Plasma Testosterone ◽

Testosterone Levels ◽

Basal Plasma ◽

Normal Males ◽

A Minor ◽

Secondary Hypogonadism

ABSTRACT Metyrapone was administered either orally, 750 mg every four h, in a total of six doses, or intravenously 30 mg per kg body weight as a four h infusion. In three males with normal endocrine functions, metyrapone given orally or intravenously induced a fall in plasma testosterone and an elevation of androstenedione within 2–8 h. When metyrapone was administered to a patient given dexamethasone to suppress endogenous ACTH production, the androstenedione levels did not alter whereas the testosterone levels showed a slight, transient decrease. In two normal females metyrapone administration was followed by a marked increase in plasma androstenedione whereas testosterone showed only a minor, gradual increase. In one male patient with Addison's disease the basal plasma testosterone was normal whereas the level of androstenedione was low. Following metyrapone intravenously, there was a slight suppression of plasma testosterone but no change in the androstenedione concentration. In one patient with primary hypogonadism, two with secondary hypogonadism and two with Klinefelter's syndrome the plasma testosterone was low under basal conditions and did not change following metyrapone. Basal plasma androstenedione was within the range for normal males and increased markedly following metyrapone in all the cases.

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GONADOTROPHIN PATTERNS IN MALE AND FEMALE RATS:

Acta Endocrinologica ◽

10.1530/acta.0.0580600 ◽

1968 ◽

Vol 58 (4) ◽

pp. 600-612 ◽

Cited By ~ 1

Author(s):

Robert Boyd ◽

Donald C. Johnson

Keyword(s):

Ascorbic Acid ◽

Testosterone Propionate ◽

Female Rats ◽

Female Rat ◽

Feedback Effects ◽

Male And Female ◽

Prostate Weight ◽

Male And Female Rats ◽

Males And Females ◽

Normal Males

ABSTRACT The effects of various doses of testosterone propionate (TP) upon the release of luteinizing hormone (LH or ICSH) from the hypophysis of a gonadectomized male or female rat were compared. Prostate weight in hypophysectomized male parabiotic partners was used to evaluate the quantity of circulating LH. Hypophyseal LH was measured by the ovarian ascorbic acid depletion method. Males castrated when 45 days old secreted significantly more LH and had three times the amount of pituitary LH as ovariectomized females. Administration of 25 μg TP daily reduced the amount of LH in the plasma, and increased the amount in the pituitary gland, in both sexes. Treatment with 50 μg caused a further reduction in plasma LH in males, but not in females, while pituitary levels in both were equal to that of their respective controls. LH fell to the same low level in partners of males or females receiving 100 μg TP. When gonadectomized at 39 days, males and females had the same amount of plasma LH, but males had more stored hormone. Pituitary levels were unchanged from controls following treatment with 12.5, 25 or 50 μg TP daily, but plasma values dropped an equal amount in both sexes with the latter two doses. Androgenized males or females, gonadectomized when 39 days old, were very sensitive to the effects of TP and plasma LH was significantly reduced with 12.5 μg daily. Pituitary LH in androgenized males was higher than that of normal males but was reduced to normal by small amounts of TP. The amount of stored LH in androgenized females was not different from that of normal females and it was unchanged by any dose of TP tested. Results are consistent with the conclusion that the male hypothalamic-hypophyseal axis is at least as sensitive as the female axis to the negative feedback effects of TP. Androgenization increases the sensitivity to TP in both males and females.

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THE EFFECT OF METOPIRONE ON THE URINARY EXCRETION OF TESTOSTERONE AND EPITESTOSTERONE IN NORMAL MALES TREATED WITH HCG OR CYPROTERONE AND IN HIRSUTE FEMALES

Acta Endocrinologica ◽

10.1530/acta.0.0670151 ◽

1971 ◽

Vol 67 (1) ◽

pp. 151-158 ◽

Cited By ~ 2

Author(s):

J. Tamm ◽

K. D. Voigt

Keyword(s):

Urinary Excretion ◽

Simultaneous Treatment ◽

Normal Males ◽

Different Origin

ABSTRACT The increased urinary excretion of testosterone and epitestosterone following the administration of HCG or Cyproterone to normal males was markedly reduced by simultaneous treatment with metopirone. In females with hirsutism of different origin the pathologically increased values of testosterone and epitestosterone in urine were also lowered considerably by 74 % and 86 %, respectively, after the administration of metopirone for a period of four days.

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THE INFLUENCE OF 17α-METHYL-19-NORTESTOSTERONE ON THE ENDOCRINE FUNCTION OF THE ADRENAL CORTEX

Acta Endocrinologica ◽

10.1530/acta.0.xxxiii0388 ◽

1960 ◽

Vol XXXIII (III) ◽

pp. 388-400 ◽

Cited By ~ 6

Author(s):

L. G. Huis in 't Veld ◽

B. Louwerens ◽

P. A. F. van der Spek

Keyword(s):

Urinary Excretion ◽

Adrenal Cortex ◽

Direct Effect ◽

Chorionic Gonadotrophin ◽

Endocrine Function ◽

List Type ◽

Prolonged Administration ◽

Acth Secretion ◽

Male Patients ◽

Normal Males

ABSTRACT In two male patients and two castrated males, the influence of corticotrophin (ACTH) on the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period in which patients were treated with 5 mg 17α-methyl-19-nortestosterone (MNT) daily. In two castrated males, moreover, the influence of chorionic gonadotrophin and ACTH + chorionic gonadotrophin on the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period of treatment with 5 mg MNT daily. Prolonged administration of MNT causes a decrease in the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids both in the normal males and in the male castrates. ACTH caused an increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids before and during MNT administration. During MNT administration this increase (expressed in mg/24 hours) was ≤ the increase produced by the same dose of ACTH prior to MNT administration. In two male castrates treated with MNT, chorionic gonadotrophin caused no increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids. The effect obtained before and during MNT administration by administration of ACTH + chorionic gonadotrophin did not exceed the effect obtained by the same dose of ACTH alone. Our conclusion is that the effect of MNT on the excretion of adrenocortical steroids is not due to the inhibition of the ACTH secretion. The possibility of a direct effect of MNT on the adrenal cortex has not been excluded with complete certainty. A change in the corticosteroid metabolism due to the influence of MNT, however, must also be taken into consideration.

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