Effects of Cocaine on Intracellular Calcium Handling In Cardiac and Vascular Smooth Muscle

1991 ◽  
Author(s):  
Cynthia L. Perreault ◽  
◽  
Kathleen G. Morgan ◽  
James P. Morgan
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Intracellular Calcium ◽  
Calcium Handling

Recycling and buffering of intracellular calcium in vascular smooth muscle from genetically hypertensive rats

1994 ◽  
Vol 12 (12) ◽  
pp. 1365???1372 ◽  
Author(s):  
Nancy L. Kanagy ◽  
Maria N. Ansari ◽  
Sanjay Ghosh ◽  
R. Clinton Webb
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Intracellular Calcium ◽  
Hypertensive Rats ◽  
Genetically Hypertensive Rats ◽  
Genetically Hypertensive

scholarly journals Chromium Picolinate Modulates Rat Vascular Smooth Muscle Cell Intracellular Calcium Metabolism

1998 ◽  
Vol 128 (2) ◽  
pp. 180-184 ◽  
Author(s):  
Jerry W. Moore ◽  
Margaret A. Maher ◽  
William J. Banz ◽  
Michael B. Zemel
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Intracellular Calcium ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Calcium Metabolism ◽  
Chromium Picolinate

Adenine-induced chronic renal failure in rats decreases aortic relaxation rate and alters expression of proteins involved in vascular smooth muscle calcium handling

2016 ◽  
Vol 218 (4) ◽  
pp. 250-264 ◽  
Author(s):  
L. Nguy ◽  
E. Shubbar ◽  
M. Jernås ◽  
I. Nookaew ◽  
J. Lundgren ◽  
...  
Keyword(s):  
Renal Failure ◽  
Smooth Muscle ◽  
Chronic Renal Failure ◽  
Vascular Smooth Muscle ◽  
Relaxation Rate ◽  
Calcium Handling ◽  
Muscle Calcium

scholarly journals Intracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model

2016 ◽  
pp. gfw274 ◽  
Author(s):  
Stacey Dineen Rodenbeck ◽  
Chad A. Zarse ◽  
Mikaela L. McKenney-Drake ◽  
Rebecca S. Bruning ◽  
Michael Sturek ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Smooth Muscle ◽  
Kidney Disease ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Intracellular Calcium ◽  
Vascular Smooth Muscle Cells ◽  
Rat Model ◽  
Muscle Cells

scholarly journals Insulin reduces contraction and intracellular calcium concentration in vascular smooth muscle.

Hypertension ◽  
1993 ◽  
Vol 22 (5) ◽  
pp. 735-742 ◽  
Author(s):  
A M Kahn ◽  
C L Seidel ◽  
J C Allen ◽  
R G O'Neil ◽  
H Shelat ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Intracellular Calcium Concentration

scholarly journals Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells

2020 ◽  
Vol 318 (1) ◽  
pp. L112-L124 ◽  
Author(s):  
Sangeeta Bhallamudi ◽  
Jennifer Connell ◽  
Christina M Pabelick ◽  
Y. S. Prakash ◽  
Venkatachalem Sathish
Keyword(s):  
Smooth Muscle ◽  
Estrogen Receptors ◽  
Intracellular Calcium ◽  
Airway Smooth Muscle ◽  
Airway Remodeling ◽  
Clinical Findings ◽  
Calcium Handling ◽  
Airway Smooth Muscle Cells ◽  
Adult Women ◽  
Channel Inhibition

Asthma is defined as chronic inflammation of the airways and is characterized by airway remodeling, hyperresponsiveness, and acute bronchoconstriction of airway smooth muscle (ASM) cells. Clinical findings suggest a higher incidence and severity of asthma in adult women, indicating a concrete role of sex steroids in modulating the airway tone. Estrogen, a major female sex steroid mediates its role through estrogen receptors (ER) ERα and ERβ, which are shown to be expressed in human ASM, and their expression is upregulated in lung inflammation and asthma. Previous studies suggested rapid, nongenomic signaling of estrogen via ERs reduces intracellular calcium ([Ca2+]i), thereby promoting relaxation of ASM. However, long-term ER activation on [Ca2+]i regulation in human ASM during inflammation or in asthma is still not known. In Fura-2-loaded nonasthmatic and asthmatic human ASM cells, we found that prolonged (24 h) exposure to ERα agonist (PPT) increased [Ca2+]i response to histamine, whereas ERβ activation (WAY) led to decreased [Ca2+] compared with vehicle. This was further confirmed by ER overexpression and knockdown studies using various bronchoconstrictor agents. Interestingly, ERβ activation was more effective than 17β-estradiol in reducing [Ca2+]i responses in the presence of TNF-α or IL-13, while no observable changes were noticed with PPT in the presence of either cytokine. The [Ca2+]i-reducing effects of ERβ were mediated partially via L-type calcium channel inhibition and increased Ca2+ sequestration by sarcoplasmic reticulum. Overall, these data highlight the differential signaling of ERα and ERβ in ASM during inflammation. Specific ERβ activation reduces [Ca2+]i in the inflamed ASM cells and is likely to play a crucial role in regulating ASM contractility, thereby relaxing airways.

scholarly journals Platelet-activating factor mobilises intracellular calcium in vascular smooth muscle cells

FEBS Letters ◽  
1986 ◽  
Vol 197 (1-2) ◽  
pp. 13-16 ◽  
Author(s):  
Valerie M. Doyle ◽  
Judith A. Creba ◽  
Urs T. Rüegg
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Intracellular Calcium ◽  
Vascular Smooth Muscle Cells ◽  
Platelet Activating Factor ◽  
Muscle Cells

Endothelin-induced changes in intracellular calcium concentration in rat vascular smooth muscle cells: Effects of extracellular calcium and atrial natriuretic factor

1992 ◽  
Vol 7 (1) ◽  
pp. 37-41 ◽  
Author(s):  
Motoyuki Nakamura ◽  
Tessa J. Abell ◽  
A. Mark Richards ◽  
Hamid Ikram ◽  
Eric A. Espiner ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Intracellular Calcium ◽  
Vascular Smooth Muscle Cells ◽  
Atrial Natriuretic Factor ◽  
Calcium Concentration ◽  
Muscle Cells ◽  
Extracellular Calcium ◽  
Induced Changes
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