Attentional Switching and Rapid Information Processing in Mild Cognitive Impairment

2007 ◽  
Author(s):  
Sylvie Belleville ◽  
Pierre Jolicoeur ◽  
Serge Gauthier
Keyword(s):  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment ◽  
Attentional Switching ◽  
Rapid Information Processing

Effects of commonly prescribed drugs on cognition and mild cognitive impairment in healthy elderly people

2019 ◽  
Vol 33 (8) ◽  
pp. 965-974 ◽  
Author(s):  
Teodoro del Ser ◽  
María-Ascensión Zea ◽  
Meritxell Valentí ◽  
Javier Olazarán ◽  
Jorge López-Álvarez ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment ◽  
Elderly People ◽  
Longitudinal Analyses ◽  
Negative Effects ◽  
Cross Sectional ◽  
Positive Effects ◽  
Healthy Elderly

Background:Chronic drug intake has been associated with negative and positive cognitive effects in elderly people, although subjacent conditions may be confounding factors.Aim:To study the effects on cognitive performance of commonly prescribed medications in a cohort of cognitively normal older adults.Methods:Medication intake was recorded during two years in 1087 individuals 70–85 years old, without neurological or psychiatric conditions. The influence of every drug, drug family and therapeutic group on six cognitive scores and on the conversion to mild cognitive impairment over two years was ascertained by cross-sectional and longitudinal analyses controlling for demographic and clinical variables.Results:Small effects of several drugs on information processing were found in cross-sectional analyses but only confirmed for a positive effect of vitamin D in case–control analyses. Longitudinal analyses showed no drug effects on the cognitive slopes. Several hypotensive drugs reduced, whereas bromazepam and glucose lowering drugs increased, the conversion rate to mild cognitive impairment with very small effects ( R2=0.3–1%).Conclusions:Cognitively healthy elderly individuals show minimal negative effects on information processing associated with chronic intake of some drugs probably related to the subjacent condition. Some drugs slightly affect the rate of conversion to mild cognitive impairment. Positive effects of vitamin D, chondroitin, atorvastatin and antihypertensive drugs, and negative effects of antidepressants and benzodiazepines, should be further explored in studies with longer follow-up.

Targeted Cognitive Game Training Enhances Cognitive Performance in Multiple Sclerosis Patients Treated With Interferon Beta 1-a

2021 ◽  
Author(s):  
Shay Menascu ◽  
Roy Aloni ◽  
Mark Dolev ◽  
David Magalashvili ◽  
Keren Gutman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Cognitive Performance ◽  
Processing Speed ◽  
Interferon Beta ◽  
Training Group ◽  
Information Processing Speed

Abstract BackgroundPrevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of short-term computerized game training on cognitive performance in MS patients with mild cognitive impairment.MethodsWe enrolled in this prospective study 100 eligible MS patients treated with Interferon-beta-1a (Rebif). All had mild cognitive impairment in either executive function or information processing speed. Patients were randomized 1:1 to either use the cognitive games platform byHappyNeuron (HN) or receive no intervention. Executive function and information processing speed scores were measured at 3 and 6 months from baseline to evaluate the effect of game training on cognitive scores.ResultsIn both executive function and information processing speed, the game Training group showed significant improvement after 3 and 6 months. The Non-Training group showed mild deterioration in both domains at 3 months, and further deterioration that became significant at 6 months in executive function. Furthermore, at 6 months, the percent of patients in the Training group that improved or remained stable in both cognitive domains was significantly higher compared to the Non-Training group.ConclusionsOur findings suggest that cognitive game training has a beneficial effect on cognitive performance in MS patients suffering from mild cognitive impairment. While further evaluation is required to assess the longevity of that effect, we nonetheless recommend to MS patients to be engaged in cognitive gaming practice as part of a holistic approach to treating their condition.

Altered Topology in Information Processing of a Narrated Story in Older Adults with Mild Cognitive Impairment

2016 ◽  
Vol 53 (2) ◽  
pp. 517-533 ◽  
Author(s):  
Galit Yogev-Seligmann ◽  
Noga Oren ◽  
Elissa L. Ash ◽  
Talma Hendler ◽  
Nir Giladi ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment

scholarly journals Measuring Information Processing Speed in Mild Cognitive Impairment: Clinical Versus Research Dichotomy

2016 ◽  
Vol 51 (1) ◽  
pp. 263-275 ◽  
Author(s):  
Judy Haworth ◽  
Michelle Phillips ◽  
Margaret Newson ◽  
Peter J. Rogers ◽  
Anna Torrens-Burton ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment ◽  
Processing Speed ◽  
Information Processing Speed

Validity of a Novel Touch Screen Tablet-Based Assessment for Mild Cognitive Impairment and Probable AD in Older Adults

Assessment ◽  
2017 ◽  
Vol 26 (8) ◽  
pp. 1540-1553 ◽  
Author(s):  
Yo-Ping Huang ◽  
Avichandra Singh ◽  
Sheng Chen ◽  
Fang-Ju Sun ◽  
Chiu-Ron Huang ◽  
...  
Keyword(s):  
Older Adults ◽  
Motor Control ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment ◽  
Processing Speed ◽  
Touch Screen ◽  
Cognitive Test ◽  
Information Processing Speed ◽  
Visuospatial Perception

This study aimed to develop a psychometrically valid touch screen tablet-based cognitive test battery to identify early cognitive impairment due to dementia in older adults. The battery includes eight tests with 13 subscores, evaluating visual attention, auditory attention, information processing speed, visual memory, motor control, and visuospatial perception. Among the participants, 43 had been diagnosed with mild cognitive impairment (MCI) and 36 with probable Alzheimer’s disease (AD); 41 had no cognitive impairment. The average time to administer the tablet-based tests was 10 minutes. Significant correlations with the Mini-Mental State Examination were found in 9 out of 13 subscores. Patients with probable AD scored significantly lower than controls in 8 out of 13 subscores, whereas those with MCI scored significantly lower in 4 out of 13 subscores. Confirmatory factor analysis using Promax rotation showed that four factors caused lower subscores in the MCI group compared with the controls: information processing speed, memory, visuospatial perception, and motor control. All four factors significantly discriminated the controls from the MCI and probable AD groups, and in the expected direction. The touch screen tablet-based cognitive test battery is psychometrically valid for evaluating cognition in older adults.

scholarly journals Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Shay Menascu ◽  
Roy Aloni ◽  
Mark Dolev ◽  
David Magalashvili ◽  
Keren Gutman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Information Processing ◽  
Executive Function ◽  
Mild Cognitive Impairment ◽  
Cognitive Performance ◽  
Processing Speed ◽  
Interferon Beta ◽  
Training Group ◽  
Information Processing Speed

Abstract Background Prevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of a 6 months computerized game training program on cognitive performance in MS patients with mild cognitive impairment. Methods This was a single-center, randomized prospective study. We enrolled in this study 100 eligible MS patients treated with Interferon-beta-1a (Rebif). All had mild cognitive impairment in either executive function or information processing speed. Patients were randomized 1:1 to either use the cognitive games platform by HappyNeuron (HN) or receive no intervention. Executive function and information processing speed scores were measured at 3 and 6 months from baseline to evaluate the effect of game training on cognitive scores. Results In both executive function and information processing speed, the game Training group showed significant improvement after 3 and 6 months. The Non-Training group showed mild deterioration in both domains at 3 months, and further deterioration that became significant at 6 months in executive function. Furthermore, at 6 months, the percent of patients in the Training group that improved or remained stable in both cognitive domains was significantly higher compared to the Non-Training group. Conclusions Our findings suggest that cognitive game training has a beneficial effect on cognitive performance in MS patients suffering from mild cognitive impairment. While further evaluation is required to assess the longevity of that effect, we nonetheless recommend to MS patients to be engaged in cognitive gaming practice as part of a holistic approach to treating their condition.

scholarly journals Temporal dynamics of animacy categorization in the brain of patients with mild cognitive impairment

2020 ◽  
Author(s):  
Hamed Karimi ◽  
Haniye Marefat ◽  
Mahdiyeh Khanbagi ◽  
Chris Kalafatis ◽  
Mohammad Hadi Modarres ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Information Processing ◽  
Mild Cognitive Impairment ◽  
Temporal Dynamics ◽  
Critical Time ◽  
Multivariate Pattern Analysis ◽  
Activation Level ◽  
Potential Biomarker ◽  
Multivariate Pattern ◽  
The Brain

Electroencephalography (EEG) has been commonly used to measure brain alterations in Alzheimer's Disease (AD). However, reported changes are limited to those obtained from using univariate measures, including activation level and frequency bands. To look beyond the activation level, we used multivariate pattern analysis (MVPA) to elicit the pattern of information processing from EEG responses to an animacy categorization task. Comparing healthy controls (HC) with patients with mild cognitive impairment (MCI), we found that the neural speed of animacy information processing is decreased in MCI patients. Moreover, we found critical time-points during which the representational pattern of animacy for MCI patients was significantly discriminable from that of HC, while the activation level remained unchanged. Together, these results suggest that the speed and pattern of animacy information processing provide clinically useful information as a potential biomarker for detecting early changes in MCI and AD patients.

Sign in / Sign up

Export Citation Format

Share Document