Physical Activity, Mood, and Immune Function in Metastatic Breast Cancer

2013 ◽  
Author(s):  
Arianna Aldridge-Gerry ◽  
Oxana G. Palesh ◽  
Firdaus S. Dhabhar ◽  
Jamie M. Zeitzer ◽  
Booil Jo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Metastatic Breast Cancer ◽  
Immune Function ◽  
Metastatic Breast

Physical Activity and Survival Subsequent to Metastatic Breast Cancer Diagnosis

2010 ◽  
Author(s):  
Susan Sharp ◽  
Ashleigh Golden ◽  
Cheryl Koopman ◽  
Eric Neri ◽  
David Spiegel
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Metastatic Breast Cancer ◽  
Cancer Diagnosis ◽  
Metastatic Breast ◽  
Breast Cancer Diagnosis

scholarly journals Physical Activity, Weight, and Outcomes in Patients Receiving Chemotherapy for Metastatic Breast Cancer (C40502/Alliance)

2021 ◽  
Author(s):  
Jennifer A Ligibel ◽  
Luke Huebner ◽  
Hope S Rugo ◽  
Harold J Burstein ◽  
Debra L Toppmeyer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Body Mass Index ◽  
Metastatic Breast Cancer ◽  
Body Mass ◽  
Hormone Receptor ◽  
Metastatic Breast ◽  
Hazard Ratio ◽  
First Line ◽  
Risk Of Cancer

Abstract Background Obesity and inactivity are associated with increased risk of cancer related- and overall mortality in breast cancer, but there are few data in metastatic disease. Methods CALGB 40502 was a randomized trial of first-line taxane-based chemotherapy for patients with metastatic breast cancer. Height and weight were collected at enrollment. After 299 patients enrolled, the study was amended to assess recreational physical activity (PA) at enrollment using the Nurses’ Health Study Exercise Questionnaire. Associations with progression-free survival (PFS) and overall survival (OS) were evaluated using stratified Cox modeling (strata included hormone receptor status, prior taxane, bevacizumab use, and treatment arm). Results 799 patients were enrolled and at the time of data lock, median follow-up was 60 months. At enrollment, median age was 56.7 years, 73.1% of participants had hormone receptor-positive cancers, 42.6% had obesity, and 47.6% engaged in less than 3 metabolic equivalents of task (MET)-hours of PA/week (<1 hour of moderate PA). Neither baseline body mass index nor PA was statistically significantly associated with PFS or OS, although there was a marginally statistically significant increase in PFS (hazard ratio = 0.83, 95% confidence interval [CI] = 0.79, 1.02; p = .08) and OS (hazard ratio = 0.81, 95% CI = 0.65, 1.02; p = .07) in patients who reported PA greater than 9 MET-hours/week vs 0–9 MET-hours/week. Conclusions In a trial of first-line chemotherapy for metastatic breast cancer, rates of obesity and inactivity were high. There was no statistically significant relationship between body mass index and outcomes. More information is needed regarding the relationship between PA and outcomes.

scholarly journals Physical activity and lifestyle in women with metastatic breast cancer: The ABLE study

2018 ◽  
Vol 29 ◽  
pp. viii116
Author(s):  
B. Fervers ◽  
L. Delrieu ◽  
O. Pérol ◽  
O. Febvey-Combes ◽  
A. Dufresne ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Metastatic Breast Cancer ◽  
Metastatic Breast

Randomized trial of a physical activity intervention in women with metastatic breast cancer

Cancer ◽  
2016 ◽  
Vol 122 (8) ◽  
pp. 1169-1177 ◽  
Author(s):  
Jennifer A. Ligibel ◽  
Anita Giobbie-Hurder ◽  
Laura Shockro ◽  
Nancy Campbell ◽  
Ann H. Partridge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Metastatic Breast Cancer ◽  
Randomized Trial ◽  
Physical Activity Intervention ◽  
Metastatic Breast

scholarly journals Feasibility and Health Benefits of an Individualized Physical Activity Intervention in Women With Metastatic Breast Cancer: Intervention Study (Preprint)

2018 ◽  
Author(s):  
Lidia Delrieu ◽  
Vincent Pialoux ◽  
Olivia Pérol ◽  
Magali Morelle ◽  
Agnès Martin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Physical Activity ◽  
Metastatic Breast Cancer ◽  
Intervention Study ◽  
Physical Activity Intervention ◽  
Metastatic Breast ◽  
Physical Activity Program ◽  
Activity Program

BACKGROUND There is limited knowledge regarding the potential benefits of physical activity in patients with metastatic breast cancer. OBJECTIVE The Advanced stage Breast cancer and Lifestyle Exercise (ABLE) Trial aimed to assess the feasibility of a physical activity intervention in women with metastatic breast cancer and to explore the effects of physical activity on functional, psychological, and clinical parameters. METHODS The ABLE Trial was a single-arm, 6-month intervention study with a home-based, unsupervised, and personalized walking program using an activity tracker. At baseline and 6 months, we assessed anthropometrics, functional fitness, physical activity level, sedentary behavior, quality of life, fatigue, and tumor progression. Paired proportions were compared using the McNemar test and changes of parameters during the intervention were analyzed using the Wilcoxon signed-rank test, the Mann-Whitney test, and Spearman rank correlations. RESULTS Overall, 49 participants (mean age 55 years; recruitment rate 94%) were enrolled and 96% adhered to the exercise prescription (attrition rate 2%). Statistically significant improvements in the 6-minute walking distance test (+7%, <i>P</i>&lt;.001) and isometric quadriceps strength (+22%, <i>P</i>&lt;.001), as well as decreases in body mass index (-2.5%, <i>P</i>=.03) and hip circumference (-4.0%, <i>P</i>&lt;.001) were observed at 6 months. Quality of life remained stable and a nonstatistically significant decrease (-16%, <i>P</i>=.07) in fatigue was observed. CONCLUSIONS The high recruitment and adherence rates suggest the willingness of patients with metastatic breast cancer to participate in a physical activity program. The beneficial outcomes regarding physical fitness and anthropometry of this unsupervised physical activity program may encourage these patients to maintain a physically active lifestyle. Future randomized controlled trials with larger sample sizes are warranted. CLINICALTRIAL ClinicalTrials.gov NCT03148886; https://clinicaltrials.gov/ct2/show/NCT03148886 INTERNATIONAL REGISTERED REPORT RR2-10.2196/10487

scholarly journals Physical activity and fitness in women with metastatic breast cancer.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 136-136
Author(s):  
Jasmine Yee ◽  
Glen M Davis ◽  
Jane McNeil Beith ◽  
Nicholas Wilcken ◽  
Rina Hui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Metastatic Breast Cancer ◽  
Aerobic Fitness ◽  
Lower Limb ◽  
Handgrip Strength ◽  
Disease Onset ◽  
Metastatic Breast ◽  
Activity Levels ◽  
Lower Limb Strength

136 Background: Women with metastatic breast cancer may survive for many years after disease onset, and there is little published evidence on their habitual levels of physical activity. The aim of this study was to investigate differences in physical activity levels and physical fitness between women with and without metastatic breast cancer. Methods: Seventy-one women with metastatic breast cancer (METS) aged 57.7 ± 9.5 y and 2.9 ± 3.1 y after disease onset, and 71 healthy controls (CONTROLS) aged 55.0 ± 9.4 y participated. Of those with metastatic disease, 27% had metastases in bone only, 35% in viscera only and 38% in both bone and viscera. Strength was measured using hand and leg dynamometry, aerobic fitness using the Modified Canadian Aerobic Fitness Test, and fatigue with the FACT-Fatigue questionnaire. Participants wore a SenseWear physical activity armband over 6 days, and the average steps taken per day over 5 of these days, where there was a minimum wear time of 8 hours per day, was derived. Results: METS possessed lower aerobic fitness than CONTROLS (25.3 ± 5.4 versus 31.9 ± 6.1 ml·kg·min-1 respectively; p<0.01). METS were significantly weaker than CONTROLS. Lower limb strength for the METS and CONTROLS was 53.8 ± 23.7 versus 76.0 ± 27.4 kg and handgrip strength was 26.6 ± 6.0 versus 30.2 ± 6.4 kg. METS were also significantly less active, attaining only 57% of the daily step counts of CONTROLS. Fatigue was significantly higher in women with metastatic cancer compared to their healthy counterparts (38.0 ± 9.8 versus 46.3 ± 4.6; p<0.01). Correlation between fatigue with average steps per day (r=0.46), handgrip strength (r=0.29) and leg strength (r=0.26) was low in the METS group. Conclusions: Women living in the community with metastatic breast cancer are weaker, have lower aerobic fitness, and are relatively inactive compared to their healthy counterparts. Increased fatigue in these women is poorly associated with their decreased physical activity levels, hand and lower limb strength. Women with metastatic breast cancer may benefit from a program directed at improving their strength and fitness. Acknowledgements: Funded by National Breast Cancer Foundation, Australia.

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