It is common for elite players to represent their respective countries in international competitions. However, there is a potential cost to the club team derived from that situation (risk of injury, fatigue, psychological momentum, etc.). This paper evaluates the impact of players’ absence on European football teams’ performance by focusing on the Africa Cup of Nations as the case study. The results indicate that the sending of players to the African tournament has a relatively small negative impact on teams’ performance. But this cannot be generalized to all the leagues and loses significance when corrected by players’ abilities.