Cognitions matter: The role of cognitive mediators in improving interpersonal functioning and symptoms of depression.

2019 ◽  
Vol 29 (3) ◽  
pp. 261-276 ◽  
Author(s):  
Martin Drapeau ◽  
Debora A. D'Iuso ◽  
David Dunkley ◽  
Keith S. Dobson ◽  
Michelle Azzi ◽  
...  
Keyword(s):  
Interpersonal Functioning ◽  
Symptoms Of Depression ◽  
Cognitive Mediators

scholarly journals A continuum hypothesis of psychotomimetic rapid antidepressants

2021 ◽  
Vol 5 ◽  
pp. 239821282110077
Author(s):  
Joost Haarsma ◽  
Catherine J Harmer ◽  
Sandra Tamm
Keyword(s):  
Continuum Hypothesis ◽  
Sense Of Self ◽  
Predictive Coding ◽  
Common Mechanism ◽  
Symptoms Of Depression ◽  
Research Areas ◽  
Sensory Evidence ◽  
Perceptual Distortions ◽  
Psychotomimetic Effects

Ketamine, classical psychedelics and sleep deprivation are associated with rapid effects on depression. Interestingly, these interventions also have common psychotomimetic actions, mirroring aspects of psychosis such as an altered sense of self, perceptual distortions and distorted thinking. This raises the question whether these interventions might be acute antidepressants through the same mechanisms that underlie some of their psychotomimetic effects. That is, perhaps some symptoms of depression can be understood as occupying the opposite end of a spectrum where elements of psychosis can be found on the other side. This review aims at reviewing the evidence underlying a proposed continuum hypothesis of psychotomimetic rapid antidepressants, suggesting that a range of psychotomimetic interventions are also acute antidepressants as well as trying to explain these common features in a hierarchical predictive coding framework, where we hypothesise that these interventions share a common mechanism by increasing the flexibility of prior expectations. Neurobiological mechanisms at play and the role of different neuromodulatory systems affected by these interventions and their role in controlling the precision of prior expectations and new sensory evidence will be reviewed. The proposed hypothesis will also be discussed in relation to other existing theories of antidepressants. We also suggest a number of novel experiments to test the hypothesis and highlight research areas that could provide further insights, in the hope to better understand the acute antidepressant properties of these interventions.

scholarly journals Associations of immunometabolic risk factors with symptoms of depression and anxiety: The role of cardiac vagal activity

2018 ◽  
Vol 73 ◽  
pp. 493-503 ◽  
Author(s):  
Mandy X. Hu ◽  
Brenda W.J.H. Penninx ◽  
Eco J.C. de Geus ◽  
Femke Lamers ◽  
Dora C.-H. Kuan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vagal Activity ◽  
Depression And Anxiety ◽  
Symptoms Of Depression

Depression: An insight into Heterocyclic and Cyclic Hydrocarbon Compounds inspired from Natural Sources

2021 ◽  
Vol 19 ◽  
Author(s):  
Abdul Jalil Shah ◽  
Reyaz Hassan Mir ◽  
Roohi Mohi-ud-din ◽  
Faheem Hyder Pottoo ◽  
Mubashir Hussain Masoodi ◽  
...  
Keyword(s):  
Gaba Receptors ◽  
Herbal Medicines ◽  
Aminobutyric Acid ◽  
Cyclic Hydrocarbon ◽  
Natural Sources ◽  
Drug Candidates ◽  
Signalling Molecules ◽  
Symptoms Of Depression ◽  
Insight Into

: Depression, a well know mental disorder has global prevalence, nearly affecting 17% of population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main source for new drug candidates in depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this review is to revisit the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter depression in the CNS.

scholarly journals Effects of Polyphenols in a Mediterranean Diet on Symptoms of Depression: A Systematic Literature Review

2019 ◽  
Vol 11 (3) ◽  
pp. 602-615 ◽  
Author(s):  
Jessica Bayes ◽  
Janet Schloss ◽  
David Sibbritt
Keyword(s):  
Depressive Symptoms ◽  
Literature Review ◽  
Mediterranean Diet ◽  
Systematic Literature Review ◽  
Experimental Studies ◽  
Protective Role ◽  
Original Research ◽  
Inclusion Criteria ◽  
Symptoms Of Depression

ABSTRACT Depression is a mood disorder which currently affects 350 million individuals worldwide. Recently, research has suggested a protective role of diet for depression. The Mediterranean-style dietary pattern has been highlighted in several systematic reviews as a promising candidate for reducing depressive symptoms. It has been speculated that this could be due to the high polyphenol content of foods commonly found in the diet. Therefore, the aim of this review was to assess the effects of polyphenols found in a Mediterranean diet on the symptoms of depression. A systematic literature review was conducted of original research which assessed the role of polyphenols on the symptoms of depression in humans. The following databases were searched: PROQUEST, SCOPUS (Elsevier), MEDLINE (EBSCO), CINAHL, and EMBase, up to 18 February, 2019. The inclusion criteria consisted of both observational and experimental research in adults aged 18–80 y that assessed depression scores in relation to polyphenol intake. A total of 37 studies out of 12,084 met the full inclusion criteria. Of these, 17 were experimental studies and 20 were observational studies. Several different polyphenols were assessed including those from tea, coffee, citrus, nuts, soy, grapes, legumes, and spices. Twenty-nine of the studies found a statistically significant effect of polyphenols for depression. This review has found both an association between polyphenol consumption and depression risk, as well as evidence suggesting polyphenols can effectively alleviate depressive symptoms. The review uncovered gaps in the literature regarding the role of polyphenols for depressive symptoms in both young adults and men. This review was registered at www.crd.york.ac.uk/PROSPERO as CRD42019125747.

scholarly journals The Impact of COVID-19 on Mental Health: The Role of Locus on Control and Internet Use

2020 ◽  
Vol 17 (19) ◽  
pp. 6985
Author(s):  
Rannveig Sigurvinsdottir ◽  
Ingibjorg E. Thorisdottir ◽  
Haukur Freyr Gylfason
Keyword(s):  
Mental Health ◽  
Locus Of Control ◽  
Information Seeking ◽  
Internet Use ◽  
Online Survey ◽  
The United States ◽  
The Internet ◽  
Symptoms Of Depression ◽  
The Impact

The true extent of the mental health implications of the COVID-19 pandemic are unclear, but early evidence suggests poorer mental health among those exposed to the pandemic. The Internet may have differential effects, by both connecting people with resources, or reinforce the constant checking of negative information. Moreover, locus of control becomes important in an uncontrollable pandemic. The current study aimed to examine whether exposure to COVID-19 would relate to greater symptoms of depression, anxiety and stress, and to examine the role of internet use and locus of control. Adults in the United States and five European countries (N = 1723) answered an online survey through the website Mturk. Results show elevated psychological symptoms among those who have become infected with COVID-19 or perceive themselves to be at high risk if infected. Experience using the Internet relates to fewer symptoms, but information seeking is associated with more symptoms. Internet social capital relates to fewer symptoms of depression. Having an external locus of control relates to greater symptoms. These findings suggest that public health officials need to focus on the mental health effects of the pandemic, and that internet use and locus of control could be targets to improve mental health in the population.

scholarly journals The Relationship between Personal Resources and Depression in a Sample of Victims of Cyberbullying: Comparison of Groups with and without Symptoms of Depression

2020 ◽  
Vol 17 (24) ◽  
pp. 9307
Author(s):  
Lourdes Rey ◽  
Cirenia Quintana-Orts ◽  
Sergio Mérida-López ◽  
Natalio Extremera
Keyword(s):  
Mental Health ◽  
Emotional Intelligence ◽  
Depressive Symptoms ◽  
Clinical Symptoms ◽  
Personal Resources ◽  
Symptoms Of Depression ◽  
And Function ◽  
The Relationship ◽  
Adolescent Victims

Previous research has highlighted the relationship between being cybervictimised and the presence of clinical symptoms, such as depression. To date, however, there has been no comparative analysis of the personal resources profiles of adolescent victims of cyberbullying with and without depressive symptoms. The current study analysed the relationship between positive personal resources and clinical symptoms in 251 adolescent victims of cyberbullying at several Spanish high schools. It examined how several positive personal resources varied in adolescent victims of cyberbullying who displayed symptoms of depression (n = 89) or did not (n = 162). Victims of cyberbullying who displayed depressive symptoms reported lower levels of personal resources (emotional intelligence, gratitude, optimism, and forgiveness) than those who did not. Logistic regression provided evidence that gratitude was the strongest predictor of depressive symptoms in victims of cyberbullying, followed by emotional intelligence and optimism. These findings expand the existing literature on the role of personal resources in mental health and highlight the need for their development in youths to help them cope more effectively and function better after being cyberbullied.

Symptoms of depression in non-routine caregivers: The role of caregiver strain and burden

2009 ◽  
Vol 48 (4) ◽  
pp. 335-346 ◽  
Author(s):  
Anna C. Phillips ◽  
Stephen Gallagher ◽  
Kate Hunt ◽  
Geoff Der ◽  
Douglas Carroll
Keyword(s):  
Caregiver Strain ◽  
Symptoms Of Depression
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