scholarly journals Associations of immunometabolic risk factors with symptoms of depression and anxiety: The role of cardiac vagal activity

2018 ◽  
Vol 73 ◽  
pp. 493-503 ◽  
Author(s):  
Mandy X. Hu ◽  
Brenda W.J.H. Penninx ◽  
Eco J.C. de Geus ◽  
Femke Lamers ◽  
Dora C.-H. Kuan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vagal Activity ◽  
Depression And Anxiety ◽  
Symptoms Of Depression

scholarly journals Neuroticism and Interpretive Bias as Risk Factors for Anxiety and Depression

2020 ◽  
Vol 8 (4) ◽  
pp. 641-656
Author(s):  
Meghan Vinograd ◽  
Alexander Williams ◽  
Michael Sun ◽  
Lyuba Bobova ◽  
Kate B. Wolitzky-Taylor ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Cross Sectional ◽  
Interpretive Bias ◽  
Symptoms Of Depression ◽  
General Distress ◽  
Prospective Risk

Neuroticism has been associated with depression and anxiety both cross-sectionally and longitudinally. Interpretive bias has been associated with depression and anxiety, primarily in cross-sectional and bias induction studies. The purpose of the current study was to examine the role of interpretive bias as a prospective risk factor and a mediator of the relation between neuroticism and depressive and anxious symptoms in young adults assessed longitudinally. Neuroticism significantly predicted a broad general-distress dimension but not intermediate fears and anhedonia-apprehension dimensions or a narrow social-fears dimension. Neuroticism also significantly predicted negative interpretive bias for social scenarios. Negative interpretive bias for social scenarios did not significantly predict dimension scores, nor did it mediate the relation between neuroticism and general distress or social fears. These results suggest that although neuroticism relates to negative interpretive bias, its risk for symptoms of depression and anxiety is at most weakly conferred through negative interpretive bias.

Considering Depression and Anxiety as Risk Factors for Temporomandibular Joint Disorder

2020 ◽  
pp. 152-159
Author(s):  
Stefan Kindler ◽  
Marike Bredow-Zeden
Keyword(s):  
Risk Factors ◽  
Chronic Pain ◽  
Temporomandibular Joint ◽  
Facial Pain ◽  
Masticatory Muscles ◽  
Depression And Anxiety ◽  
Temporomandibular Joint Disorder ◽  
Social Emotional ◽  
Symptoms Of Depression ◽  
Joint Disorder

Temporomandibular joint disorder (TMD) is a painful functional disorder of the temporomandibular joint, masticatory muscles, and associated musculoskeletal structures of the head and neck. TMD is a type of chronic pain and is widely used as a model for chronic pain. The etiology of TMD pain is multifactorial. Biological, behavioral, environmental, social, emotional, and cognitive factors can contribute to TMD. TMD can manifest with musculoskeletal facial pain complaints and with different forms of jaw dysfunction. Biobehavioral studies suggest an association between TMD pain and coexisting psychopathology, including depression and anxiety. This chapter presents practical clinical recommendations on how to treat patients with symptoms of depression, anxiety, and TMD pain. The authors underline the importance of considering depression and anxiety as risk factors for TMD.

Risk Factors for Symptoms of Depression and Anxiety One Year Poststroke: A Longitudinal Study

2016 ◽  
Vol 97 (6) ◽  
pp. 919-928 ◽  
Author(s):  
Joyce A. Kootker ◽  
Maria L. van Mierlo ◽  
Jan C. Hendriks ◽  
Judith Sparidans ◽  
Sascha M. Rasquin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Depression And Anxiety ◽  
Symptoms Of Depression ◽  
One Year

scholarly journals 106EARLY LIFE RISK FACTORS FOR SYMPTOMS OF DEPRESSION AND ANXIETY IN LATER LIFE: ANALYSIS OF 4 COHORT STUDIES

2019 ◽  
Vol 48 (Supplement_1) ◽  
pp. i31-i31
Author(s):  
E V Backhouse ◽  
S D Shenkin ◽  
A McIntosh ◽  
I Deary ◽  
H Whalley ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Studies ◽  
Later Life ◽  
Depression And Anxiety ◽  
Symptoms Of Depression ◽  
Life Analysis

scholarly journals The Role of Stress and Mineralocorticoid Receptor Haplotypes in the Development of Symptoms of Depression and Anxiety During Adolescence

2020 ◽  
Vol 11 ◽  
Author(s):  
Hinke M. Endedijk ◽  
Stefanie A. Nelemans ◽  
Remmelt R. Schür ◽  
Marco P. M. Boks ◽  
Pol van Lier ◽  
...  
Keyword(s):  
Mineralocorticoid Receptor ◽  
Depression And Anxiety ◽  
Symptoms Of Depression

scholarly journals PRIMING OF MICROGLIA ACTIVITY INCREASES SUSCEPTIBILITY TO DEPRESSION-LIKE BEHAVIORS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S95-S95
Author(s):  
Tal Frolinger ◽  
Umar Iqbal ◽  
Giulio M Pasinetti
Keyword(s):  
Gene Expression ◽  
Depression And Anxiety ◽  
Toll Like Receptor 4 ◽  
Immune Priming ◽  
Symptoms Of Depression ◽  
Tlr4 Gene ◽  
Induced Changes ◽  
Increased Activity

Abstract This study investigates the role of microglia activity in stress-induced depression and anxiety and the mechanisms associated with the role of certain microbiome derived anti-inflammatory polyphenols in attenuating stress-induced microglia immune priming and symptoms of depression. We implemented a chronic unpredictable stress (CUS) paradigm to exhibit priming of microglia innate immunity in the context of the onset of depression and anxiety phenotypes. Mechanistic studies related to prophylactic treatment using dietary microbiome derived polyphenols were also investigated in this model. Depression and anxiety phenotypes, gene expression in microglia and protein expression in the cortex of mice were measured following a primary exposure to short-term unpredictable stress (US) followed by CUS. We examined the long-term, persistent CUS induced changes at 4-weeks of post-stress rest following a secondary US exposure. We found depression phenotypes resulted from US only following exposure to CUS. This was accompanied by an increase and persistent upregulation of toll-like receptor 4 (TLR4), RAGE, and HMGB1 gene expression in isolated cortical microglia. Priming by CUS also amplified gene expression of IL-1β in microglia and protein IL-1β in the cerebral cortex following US re-exposure. Increased activity of NF-kB was also noted in the period following CUS. Furthermore, polyphenol treatment prevented stress-induced phenotypes, upregulation of HMGB1, IL-1B, and TLR4 gene expression, as well as upregulation of IL-1β and NF-kB. The study suggests that latent activity of the TLR4-NFkB-IL1β pathway contributes to immune priming and increases susceptibility to depression-like behaviors. Anti-depressant effects of polyphenols may result from their ability to attenuate microglia priming.

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