Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

CD36 was described nearly 30 years ago as “glycoprotein IV” the fourth major band of 88KD observed on SDS-PAGE of platelet membrane (1). It is present on many mammalian cell types: microvascular endothelium; professional phagocytes including macrophages, dendritic cells, microglia and retinal pigment-epithellium; erythroid precursors; hepatocytes; adipocytes; cardiac and skeletal myocytes; and specialized epithelia of the breast, kidney and gut (2). As a pattern recognition receptor, CD36 binds a diverse set of ligands, including oxidized low-density lipoprotein (oxLDL)(5), anionic phospholipids (4), long-chain fatty acids, thrombospondin-1, fibrillar -amyloid, and the membrane of cells undergoing apoptosis (3, 5, 6). CD36 has been implicated in a wide variety of normal and pathologic biological functions, including angiogenesis, atherosclerosis, phagocytosis, inflammation, lipid metabolism, and removal of apoptotic cells (3, 5). In 1993, Endemann et al. first identified CD36 as a potential oxLDL receptor (7).Unlike macrophage scavenger receptor A type I and II, CD36 binds LDL that has been exposed to minimally oxidizing condition. The observation that CD36 was an oxLDL receptor was the catalyst for many to prove the role of CD36 in atherosclerosis. DOI: http://dx.doi.org/10.3126/njh.v9i1.8349 Nepalese Heart Journal Vol.9(1) 2012 pp.47-50

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Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy

10.1101/2020.02.28.969832 ◽

2020 ◽

Cited By ~ 1

Author(s):

Long Yang ◽

Tingting Geng ◽

Guang Yang ◽

Jinzhu Ma ◽

Leilei Wang ◽

...

Keyword(s):

Chikungunya Virus ◽

Scavenger Receptor ◽

Type I ◽

Chikv Infection ◽

Viral Loads ◽

Macrophage Scavenger Receptor ◽

Modified Low Density Lipoproteins ◽

Wd40 Domain ◽

Antiviral Role ◽

Increased Susceptibility

AbstractMacrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. Herein, we report that MSR1 activates autophagy to restrict infection of Chikungunya virus (CHIKV), an arthritogenic alphavirus that causes acute and chronic crippling arthralgia. Msr1 expression was rapidly upregulated after CHIKV infection in mice. Msr1 knockout mice had elevated viral loads and increased susceptibility to CHIKV arthritis along with a normal type I IFN response. Induction of LC3 lipidation by CHIKV, a marker of autophagy, was reduced in Msr1-/- cells. Mechanistically, MSR1 interacted with ATG12 through its cytoplasmic tail and this interaction was enhanced by CHIKV nsP1 protein. MSR1 repressed CHIKV replication through ATG5-ATG12-ATG16L1 and this was dependent on the FIP200-and-WIPI2-binding domain, but not the WD40 domain of ATG16L1. Our results elucidate an antiviral role for MSR1 involving the autophagic function of ATG5-ATG12-ATG16L1.

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The class A macrophage scavenger receptor type I (SR-AI) recognizes complement iC3b and mediates NF-κB activation

Protein & Cell ◽

10.1007/s13238-010-0020-3 ◽

2010 ◽

Vol 1 (2) ◽

pp. 174-187 ◽

Cited By ~ 12

Author(s):

Jason W. K. Goh ◽

Yen Seah Tan ◽

Alister W. Dodds ◽

Kenneth B. M. Reid ◽

Jinhua Lu

Keyword(s):

Scavenger Receptor ◽

Receptor Type ◽

Type I ◽

Class A ◽

Macrophage Scavenger Receptor

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The type I macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.91.5.1863 ◽

1994 ◽

Vol 91 (5) ◽

pp. 1863-1867 ◽

Cited By ~ 240

Author(s):

D. W. Dunne ◽

D. Resnick ◽

J. Greenberg ◽

M. Krieger ◽

K. A. Joiner

Keyword(s):

Scavenger Receptor ◽

Lipoteichoic Acid ◽

Type I ◽

Gram Positive ◽

Gram Positive Bacteria ◽

Macrophage Scavenger Receptor

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Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice

Communications Biology ◽

10.1038/s42003-020-01285-6 ◽

2020 ◽

Vol 3 (1) ◽

Author(s):

Long Yang ◽

Tingting Geng ◽

Guang Yang ◽

Jinzhu Ma ◽

Leilei Wang ◽

...

Keyword(s):

Chikungunya Virus ◽

Scavenger Receptor ◽

Type I ◽

Chikv Infection ◽

Viral Loads ◽

Macrophage Scavenger Receptor ◽

Modified Low Density Lipoproteins ◽

Wd40 Domain ◽

Antiviral Role ◽

Increased Susceptibility

Abstract Macrophage scavenger receptor 1 (MSR1) mediates the endocytosis of modified low-density lipoproteins and plays an important antiviral role. However, the molecular mechanism underlying MSR1 antiviral actions remains elusive. We report that MSR1 activates autophagy to restrict infection of Chikungunya virus (CHIKV), an arthritogenic alphavirus that causes acute and chronic crippling arthralgia. Msr1 expression was rapidly upregulated after CHIKV infection in mice. Msr1 knockout mice had elevated viral loads and increased susceptibility to CHIKV arthritis along with a normal type I IFN response. Induction of LC3 lipidation by CHIKV, a marker of autophagy, was reduced in Msr1−/− cells. Mechanistically, MSR1 interacted with ATG12 through its cytoplasmic tail and this interaction was enhanced by CHIKV nsP1 protein. MSR1 repressed CHIKV replication through ATG5-ATG12-ATG16L1 and this was dependent on the FIP200-and-WIPI2-binding domain, but not the WD40 domain of ATG16L1. Our results elucidate an antiviral role for MSR1 involving the autophagic function of ATG5-ATG12-ATG16L1.

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