Asymmetric Dimethylarginine (ADMA) Has a Role in Regulating Systemic Vascular Tone in Young Healthy Subjects: The Cardiovascular Risk in Young Finns Study

Abstract Introduction. Dysregulation of vascular tone (VT) is one of the cardiovascular risk factors that significantly worsens the quality of life, and can be a predictor for persistent hypertension (HTN). The identification of preclinical stages of vascular pathology is the most promising for prevention of hypertension. Therefore, it is important to investigate the polymorphism of genes which end products are involved in the regulation of blood pressure (BP) and predispose to VT dysregulation.Objective. To investigate the clinical and prognostic significance of the AGT and AGTR1 polymorphic variants associated with increased cardiovascular risk in young and relatively healthy subjects and patients with HTN. Materials and methods. The study involved 90 young healthy subjects and 62 patients with hypertension. The exclusion criteria for young subjects were as follows: organic cardiovascular and central nervous system disorders and smoking. The exclusion criteria for patients with HTN were identical. Additionally, the patients with uncontrolled HTN were not included. The VT regulation was assessed by the active standing test in which the changes in blood pressure (BP) and heart rate (HR) were measured. The polymorphism was identified using DNA pyrosequencing.Results. The relationship between BP and HR and the AGTR1 A1666C A>C and AGT M268T T>C variants was established. Both in young subjects and hypertensive patients was found that the C allele of the AGTR1 A1666C A>C variant was associated with lower HR in supine compared with subjects without this allele. The risk allele C of the M268T T>C polymorphism was associated with lower sBP and dBP during the 1st minute of upright posture. The identified features can probably be explained by the vascular tone increased at baseline in the presence of these polymorphic variants which was manifested by smaller changes in BP and HR during the active standing test compared to subjects without these allelic variants. The C allele of the AGTR1 A1666C A>C variant was associated with earlier onset of HTN.Conclusion. The identification of the AGTR1 A1666C A>C and AGT M268T T>C variants can be informative for clarifying the risk of HTN when the young subjects are examined, as well as the probability of early onset of hypertension.

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M.578 Associations between physical activity and cardiovascular risk factors in young adults: The cardiovascular risk in young finns study

Atherosclerosis ◽

10.1016/s0021-9150(04)90576-x ◽

2004 ◽

Vol 5 (1) ◽

pp. 134

Author(s):

K MANSIKKANIEMI

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Young Adults ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Young Finns Study

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Cognitive performance in young adulthood and midlife: Relations with age, sex, and education—The Cardiovascular Risk in Young Finns Study.

Neuropsychology ◽

10.1037/neu0000239 ◽

2016 ◽

Vol 30 (5) ◽

pp. 532-542 ◽

Cited By ~ 10

Author(s):

Suvi P. Rovio ◽

Katja Pahkala ◽

Jaakko Nevalainen ◽

Markus Juonala ◽

Pia Salo ◽

...

Keyword(s):

Cardiovascular Risk ◽

Cognitive Performance ◽

Young Adulthood ◽

Young Finns Study

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Effects of vitamin D supplementation on blood pressure, glucocorticoids and cardiovascular risk markers in healthy subjects

Endocrine Abstracts ◽

10.1530/endoabs.31.p184 ◽

2013 ◽

pp. 1-1

Author(s):

Emad Al-dujaili ◽

Veronica Giudice ◽

Lorna Fyfe ◽

Joanna Kita

Keyword(s):

Blood Pressure ◽

Vitamin D ◽

Cardiovascular Risk ◽

Healthy Subjects ◽

Vitamin D Supplementation ◽

Risk Markers

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Faculty Opinions recommendation of Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718059599.793481605 ◽

2013 ◽

Author(s):

Harald HHW Schmidt ◽

Robert Lukowski

Keyword(s):

Risk Factor ◽

Cardiovascular Risk ◽

Proton Pump Inhibitors ◽

Proton Pump ◽

Cardiovascular Risk Factor ◽

Asymmetric Dimethylarginine ◽

Unexpected Effect

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Participation in Organized Youth Sport as a Predictor of Adult Physical Activity: A 21-Year Longitudinal Study

Pediatric Exercise Science ◽

10.1123/pes.18.1.76 ◽

2006 ◽

Vol 18 (1) ◽

pp. 76-88 ◽

Cited By ~ 44

Author(s):

Risto Telama ◽

Xiaolin Yang ◽

Mirja Hirvensalo ◽

Olli Raitakari

Keyword(s):

Physical Activity ◽

Cardiovascular Risk ◽

Longitudinal Study ◽

High Activity ◽

Random Sample ◽

Youth Sport ◽

Physical Activity Participation ◽

Activity Participation ◽

Validated Questionnaire ◽

Young Finns Study

The aim of this study was to investigate how participation in organized competitive youth sport predicts adult physical activity. A random sample of 2,309 boys and girls ages 9–18 years participated in the Cardiovascular Risk in Young Finns Study in 1980, and 1,606 (70%) of them again in 2001. Physical activity was measured using a short, validated questionnaire. The results showed that participation in youth sport, and persistent participation in particular, significantly predicted adult physical activity. Participation in sport competitions increased the probability of high activity in adulthood more among males than females.

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