Tracking of serum HDL-cholesterol and other lipids in children and adolescents: The cardiovascular risk in young finns study

ObjectiveWe intend to assess the utility of the high-sensitivity C-reactive protein (hs-CRP) as a marker of cardiovascular risk in obese children and adolescents.MethodsThe study included children and adolescents between 6 and 18 years of age with a body mass index (BMI) higher than 2 SDS. All the patients had their blood pressure taken and hs-CRP, hepatic function, lipid profile and uric acid were determined after 12 h of fasting. Likewise, an oral glucose tolerance test was performed, determining basal glucose and insulin levels, and after stimulus. We considered the presence of metabolic syndrome when the obese children and teenagers showed at least two of the following conditions: decreased high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, hypertension or alteration in glucose metabolism.ResultsOut of the 115 obese children studied, 24% showed signs of metabolic syndrome. Those with metabolic syndrome presented higher levels of hs-CRP (mean: 3.8 mg/l; 95% CI: 2.8–4.8) in comparison with the obese patients who did not show signs of metabolic syndrome (mean: 2 mg/l; 95% CI: 1.5–2.5). After a multivariate analysis, the variables that appear to influence the changes in hs-CRP were BMI, triglycerides and HDL-cholesterol levels.ConclusionThe hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.

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Sweets and sugar-sweetened soft drink intake in childhood in relation to adult BMI and overweight. The Cardiovascular Risk in Young Finns Study

Public Health Nutrition ◽

10.1017/s1368980009005849 ◽

2009 ◽

Vol 12 (11) ◽

pp. 2018-2026 ◽

Cited By ~ 54

Author(s):

Katja Nissinen ◽

Vera Mikkilä ◽

Satu Männistö ◽

Marjaana Lahti-Koski ◽

Leena Räsänen ◽

...

Keyword(s):

Cardiovascular Risk ◽

Children And Adolescents ◽

Weight Management ◽

Soft Drink ◽

Soft Drinks ◽

Childhood And Adolescence ◽

Follow Up Study ◽

Unit Increase ◽

Young Finns Study

AbstractObjectiveTo investigate the associations of BMI and overweight in adulthood with consumption of sweets and sugar-sweetened soft drinks in childhood and with the change in consumption between childhood and adulthood.DesignLongitudinal 21-year follow-up study of Finnish children and adolescents from childhood to adulthood.SettingThe Cardiovascular Risk in Young Finns Study, comprising participants from both eastern and western Finland.SubjectsBoys (n967) and girls (n1172) aged 3–18 years at baseline in 1980.ResultsThe increase in consumption of sugar-sweetened soft drinks from childhood to adulthood was directly associated with BMI in adulthood in women (b= 0·45,P= 0·0001) but not in men. In women, BMI increased by 0·45 kg/m2for every 10-unit increase per month. Consumption of sweets and sugar-sweetened soft drinks in childhood and adolescence was not associated with BMI in adulthood. The change in consumption of sweets was not associated with BMI in adulthood. The increase in the consumption of sugar-sweetened soft drinks from childhood to adulthood was associated with being overweight (OR = 1·90, 95 % CI 1·38, 2·61) in women, but not in men. No association was found between overweight (BMI ≥ 25 kg/m2) in adulthood and consumption of sweets in childhood or the change in consumption from childhood to adulthood.ConclusionsWe conclude that direct associations exist between adulthood overweight and BMI and an increase in consumption of sugar-sweetened soft drinks in women. Thus sugar-sweetened soft drinks consumption may be important when considering weight management in women.

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Depressive symptoms and C-reactive protein: The Cardiovascular Risk in Young Finns Study

Psychological Medicine ◽

10.1017/s0033291706007574 ◽

2006 ◽

Vol 36 (6) ◽

pp. 797-805 ◽

Cited By ~ 61

Author(s):

MARKO ELOVAINIO ◽

LIISA KELTIKANGAS-JÄRVINEN ◽

LAURA PULKKI-RÅBACK ◽

MIKA KIVIMÄKI ◽

SAMPSA PUTTONEN ◽

...

Keyword(s):

Risk Factors ◽

Young Adults ◽

Depressive Symptoms ◽

Cardiovascular Risk ◽

Contraceptive Use ◽

Depressive Symptomatology ◽

Smoking Status ◽

Hdl Cholesterol ◽

Population Based ◽

Young Finns Study

Background. We tested the hypothesis that depressive symptoms in healthy young adults would be associated with elevated levels of C-reactive proteins (CRP).Method. We studied the association between depressive symptoms and CRP in 1201 young adults, as a part of the on-going population-based Cardiovascular Risk in Young Finns Study. Depressive symptoms were determined by responses to a revised version of Beck's Depression Inventory in 1992 and 2001. CRP and other known cardiac risk factors were measured in 2001.Results. Higher depressive symptomatology in 1992 and in 2001 and their means score were related to higher CRP levels (B's range from 0·24 to 0·21, p<0·001). These relationships persisted after separate adjustments for various risk factors including sex, age, education, oral contraceptive use, dietary fat, physical activity, alcohol consumption, smoking status, LDL-cholesterol, HDL-cholesterol, systolic blood pressure and history of acute infectious disease. Adjustments for obesity and triglycerides levels, however, somewhat attenuated the relationship between depressive symptoms and CRP.Conclusions. We concluded that higher levels of depressive symptoms are associated with higher levels of CRP, but this association may largely be attributable to obesity or triglycerides.

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Associations of insulin with coronary risk factors in children and adolescents. The Cardiovascular Risk in Young Finns Study

Atherosclerosis ◽

10.1016/0021-9150(94)93073-2 ◽

1994 ◽

Vol 109 (1-2) ◽

pp. 16

Author(s):

O.T. Raitakari ◽

K.V.K. Porkka ◽

I. Nuotio ◽

T. Ro¨nnemaa ◽

M. Knip ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Children And Adolescents ◽

Coronary Risk Factors ◽

Coronary Risk ◽

Young Finns Study

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M.578 Associations between physical activity and cardiovascular risk factors in young adults: The cardiovascular risk in young finns study

Atherosclerosis ◽

10.1016/s0021-9150(04)90576-x ◽

2004 ◽

Vol 5 (1) ◽

pp. 134

Author(s):

K MANSIKKANIEMI

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Young Adults ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Young Finns Study

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Cognitive performance in young adulthood and midlife: Relations with age, sex, and education—The Cardiovascular Risk in Young Finns Study.

Neuropsychology ◽

10.1037/neu0000239 ◽

2016 ◽

Vol 30 (5) ◽

pp. 532-542 ◽

Cited By ~ 10

Author(s):

Suvi P. Rovio ◽

Katja Pahkala ◽

Jaakko Nevalainen ◽

Markus Juonala ◽

Pia Salo ◽

...

Keyword(s):

Cardiovascular Risk ◽

Cognitive Performance ◽

Young Adulthood ◽

Young Finns Study

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Cardiovascular Risk Assessement in Osteoporotic Patients Using Osteoprotegerin as a Reliable Predictive Biochemical Marker

Ibn AL- Haitham Journal For Pure and Applied Science ◽

10.30526/2017.ihsciconf.1798 ◽

2018 ◽

pp. 253

Author(s):

Noora Wael Rasheed ◽

Ooroba Jameel Taresh

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Serum Level ◽

Biochemical Markers ◽

Hdl Cholesterol ◽

Predictive Marker ◽

Serum Levels ◽

Arterial Calcification ◽

The Metabolic Syndrome

Some studies indicated a relationship between increased serum levels of osteoprotegerin with arterial calcification and as a result, it leads to the risk of cardiovascular disease. In our study group we selected patients with osteoporosis, with similar age and body mass index for the assessment of the relationship between cardiovascular disease and osteoprotegerin serum level. We took into account the analysis of correlation and association between the presence of distinct patterns of atherosclerosis and associated diseases like high blood pressure, diabetes mellitus, low HDL cholesterol, increased LDL cholesterol, increased triglycerides and was the case of presence of any type of dyslipidemia, in case of pre-existent treatment. Objective of study was the assessment of osteoprotegerin value as predictive marker for cardiovascular and metabolic risk in osteoporotic patients. Our results showed significant correlations of parathyroid hormone, osteocalcin and biochemical markers of bone with glucose metabolism and lipid were found in our research, maintaining crosstalk between calcium and biochemical markers of bone and cardiovascular risk. The serum level of Osteoprotegerin has been shown to have a large predictive value for the metabolic syndrome as a cardiovascular risk standard in patients with osteoporosis. The osteoprotegerin serum levels were increased in the patients with metabolic syndrome as a protective response facing the atherosclerotic lesions.

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