scholarly journals Non-protein bound oestradiol, sex hormone binding globulin, breast cancer and breast cancer risk

1985 ◽  
Vol 51 (4) ◽  
pp. 479-484 ◽  
Author(s):  
P F Bruning ◽  
J M Bonfrèr ◽  
A A Hart
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

scholarly journals Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss

2019 ◽  
Vol 41 (11) ◽  
pp. 1602-1622 ◽  
Author(s):  
Sophia A. Stone ◽  
Claire J. Han ◽  
Taurence Senn ◽  
Larissa A. Korde ◽  
Kristen Allott ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Lifestyle Intervention ◽  
Intervention Group ◽  
Ultra Performance Liquid Chromatography ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Enzyme Linked Immunosorbent Assay ◽  
Obese Women

Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high breast cancer risk were randomized to control ( n = 7) or intervention ( n = 6) and analyzed for sex hormone levels. Serum and urine hormones were evaluated by ultra performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) and sex hormone binding globulin (SHBG) by enzyme-linked immunosorbent assay (ELISA). Serum estrone (E1) and estradiol (E2) were reduced by 12.1% and 50.8%, respectively, at 9 months in the intervention group, which differed from controls ( p = .043 and .020). This contrasted with a 73.3% increase in urine E1 at 6 months in the intervention group ( p = .035). These results suggest that a lifestyle intervention led to a favorable estrogen profile in relation to breast cancer risk.

scholarly journals Endogenous sex hormone levels and breast cancer risk

1987 ◽  
Vol 4 (4) ◽  
pp. 233-247 ◽  
Author(s):  
Lisa Begg ◽  
Lewis H. Kuller ◽  
James P. Gutai ◽  
Arlene G. Caggiula ◽  
Norman Wolmark ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sex Hormone ◽  
Hormone Levels

scholarly journals Sex Hormone-Binding Globulin (SHBG), estradiol and breast cancer

2010 ◽  
Vol 316 (1) ◽  
pp. 86-92 ◽  
Author(s):  
N. Fortunati ◽  
M.G. Catalano ◽  
G. Boccuzzi ◽  
R. Frairia
Keyword(s):  
Breast Cancer ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding
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