Sex hormone binding globulin mRNA in human breast cancer: Detection in cell lines and tumor samples

1996 ◽  
Vol 59 (3-4) ◽  
pp. 297-304 ◽  
Author(s):  
Katherine H. Moore ◽  
Kenneth A. Bertram ◽  
Richard R. Gomez ◽  
M.J. Styner ◽  
Louis A. Matej
Keyword(s):  
Breast Cancer ◽  
Cell Lines ◽  
Cancer Detection ◽  
Human Breast Cancer ◽  
Sex Hormone ◽  
Breast Cancer Detection ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Human Breast

scholarly journals Sex Hormone Binding Globulin as a Reliable Indicator of Hormone Dependence in Human Breast Cancer

1979 ◽  
Vol 190 (2) ◽  
pp. 133-138 ◽  
Author(s):  
YOICHI MURAYAMA ◽  
JOJI UTSUNOMIYA ◽  
ISAMU TAKAHASHI ◽  
MASATSUGU KITAMURA ◽  
TAKESHI TOMINAGA
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Reliable Indicator ◽  
Hormone Binding ◽  
Human Breast ◽  
Hormone Dependence

scholarly journals Nitrogen-Doped Titanium Dioxide Nanoparticles Modified by an Electron Beam for Improving Human Breast Cancer Detection by Raman Spectroscopy: A Preliminary Study

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 757
Author(s):  
Jakub Surmacki
Keyword(s):  
Breast Cancer ◽  
Raman Spectroscopy ◽  
Electron Beam ◽  
Cancer Detection ◽  
Human Breast Cancer ◽  
Breast Cancer Detection ◽  
Raman Signal ◽  
Human Breast ◽  
Doped Tio2 ◽  
Nitrogen Doped

Titanium dioxide (TiO2) is commonly used as a pigment in paints, paper products, polymer compositions, and cosmetic products, and even as a food additive or drug coating material. In recent times, it has also been used in photovoltaic cells, semiconductors, biomedical devices, and air purification. In this paper, the potential application of nitrogen-doped TiO2 nanoparticles modified by an electron beam for improving human breast cancer detection by Raman spectroscopy is presented. Raman spectroscopy (RS) is a promising noninvasive analytical technique in cancer detection that enables us to retrieve a molecular signature of the biochemical composition of cancerous tissue. However, RS still has some challenges in signal detection, mainly related to strong concurrent background fluorescence from the analyzed tissue. The Raman signal scattering is several orders of magnitude smaller than the fluorescence intensity, and strong fluorescence masks a much weaker Raman signal. The Raman results demonstrate that the N-doped TiO2 electron beam-irradiated nanoparticles amplify the Raman scattering. The intrinsic properties of the adsorbed molecules from human breast tissue and the surface properties of the N-doped TiO2 electron beam-irradiated nanoparticles (the excited electron–hole pair at the surface) have a significant effect on the enhanced Raman signal intensity.

The use of Au@SiO2 shell-isolated nanoparticle-enhanced Raman spectroscopy for human breast cancer detection

2014 ◽  
Vol 406 (22) ◽  
pp. 5425-5432 ◽  
Author(s):  
Chao Zheng ◽  
Lijia Liang ◽  
Shuping Xu ◽  
Haipeng Zhang ◽  
Chengxu Hu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Raman Spectroscopy ◽  
Cancer Detection ◽  
Human Breast Cancer ◽  
Breast Cancer Detection ◽  
Human Breast ◽  
Sio2 Shell

Ultrafast time-dependent fluorescence spectroscopy for human breast cancer detection

2012 ◽  
Author(s):  
Yang Pu ◽  
Guichen Tang ◽  
B. B. Das ◽  
C.-H. Liu ◽  
Asima Pradhan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fluorescence Spectroscopy ◽  
Cancer Detection ◽  
Human Breast Cancer ◽  
Breast Cancer Detection ◽  
Time Dependent ◽  
Human Breast

scholarly journals Histone Deacetylase Inhibitors and Microtubule Inhibitors Induce Apoptosis in Feline Luminal Mammary Carcinoma Cells

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 502
Author(s):  
Filipe Almeida ◽  
Andreia Gameiro ◽  
Jorge Correia ◽  
Fernando Ferreira
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cell Line ◽  
Cell Lines ◽  
Mammary Carcinoma ◽  
Human Breast Cancer ◽  
Histone Deacetylase Inhibitors ◽  
Trichostatin A ◽  
Human Breast ◽  
Antitumor Effects

Feline mammary carcinoma (FMC) is the third most common type of neoplasia in cats, sharing similar epidemiological features with human breast cancer. In humans, histone deacetylases (HDACs) play an important role in the regulation of gene expression, with HDAC inhibitors (HDACis) disrupting gene expression and leading to cell death. In parallel, microtubules inhibitors (MTIs) interfere with the polymerization of microtubules, leading to cell cycle arrest and apoptosis. Although HDACis and MTIs are used in human cancer patients, in cats, data is scarce. In this study, we evaluated the antitumor properties of six HDACis (CI-994, panobinostat, SAHA, SBHA, scriptaid, and trichostatin A) and four MTIs (colchicine, nocodazole, paclitaxel, and vinblastine) using three FMC cell lines (CAT-MT, FMCp, and FMCm), and compared with the human breast cancer cell line (SK-BR-3). HDACis and MTIs exhibited dose-dependent antitumor effects in FMC cell lines, and for all inhibitors, the IC50 values were determined, with one feline cell line showing reduced susceptibility (FMCm). Immunoblot analysis confirmed an increase in the acetylation status of core histone protein HDAC3 and flow cytometry showed that HDACis and MTIs lead to cellular apoptosis. Overall, our study uncovers HDACis and MTIs as promising anti-cancer agents to treat FMCs.

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