scholarly journals Apoptosis of osteosarcoma cultures by the combination of the cyclin-dependent kinase inhibitor SCH727965 and a heat shock protein 90 inhibitor

2013 ◽  
Vol 4 (3) ◽  
pp. e566-e566 ◽  
Author(s):  
W Fu ◽  
S S Sharma ◽  
L Ma ◽  
B Chu ◽  
M M Bui ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Kinase Inhibitor ◽  
Heat Shock Protein 90 ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor

scholarly journals LAM-003, a new drug for treatment of tyrosine kinase inhibitor–resistant FLT3-ITD–positive AML

2019 ◽  
Vol 3 (22) ◽  
pp. 3661-3673 ◽  
Author(s):  
Neil Beeharry ◽  
Sean Landrette ◽  
Sophia Gayle ◽  
Marylens Hernandez ◽  
Jeff E. Grotzke ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Single Agent ◽  
Heat Shock Protein 90 ◽  
Antileukemic Activity ◽  
Key Points

Key Points The heat shock protein 90 inhibitor LAM-003 displays potent in vitro and in vivo activity as a single agent and combined with venetoclax. LAM-003 retains antileukemic activity against AML cells rendered resistant to FLT3 kinase inhibitors by mutation or stromal signaling.

Glycyrrhizin effects rat hepatocytes via the reduction of heat shock protein 90 expression

2001 ◽  
Vol 120 (5) ◽  
pp. A357-A357
Author(s):  
T YOH ◽  
T NAKASHIMA ◽  
Y SUMIDA ◽  
Y KAKISAKA ◽  
H ISHIKAWA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 90 ◽  
Rat Hepatocytes
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