scholarly journals A two-stage association study identifies methyl-CpG-binding domain protein 2 gene polymorphisms as candidates for breast cancer susceptibility

2012 ◽  
Vol 20 (6) ◽  
pp. 682-689 ◽  
Author(s):  
Yadav Sapkota ◽  
Paula Robson ◽  
Raymond Lai ◽  
Carol E Cass ◽  
John R Mackey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Gene Polymorphisms ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Binding Domain ◽  
Two Stage ◽  
Domain Protein

scholarly journals A Pilot Genome-wide Association Study of Breast Cancer Susceptibility Loci in Indonesia

2015 ◽  
Vol 16 (6) ◽  
pp. 2231-2235 ◽  
Author(s):  
Samuel J Haryono ◽  
I Gusti Bagus Datasena ◽  
Wahyu Budi Santosa ◽  
Raymond Mulyarahardja ◽  
Kartika Sari
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Genome Wide

Cytokine Gene Polymorphisms and Breast Cancer Susceptibility

2006 ◽  
Vol 1089 (1) ◽  
pp. 104-109 ◽  
Author(s):  
L. SCOLA ◽  
M. VAGLICA ◽  
A. CRIVELLO ◽  
L. PALMERI ◽  
G. I. FORTE ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Polymorphisms ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Cytokine Gene ◽  
Cytokine Gene Polymorphisms

scholarly journals In Search of Breast Cancer Culprits: Suspecting the Suspected and the Unsuspected

2008 ◽  
Vol 1 ◽  
pp. 117822340800100
Author(s):  
Goberdhan P. Dimri
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Association Studies ◽  
Susceptibility Gene ◽  
Breast Cancer Susceptibility ◽  
Population Based ◽  
Breast Cancer Susceptibility Gene ◽  
Candidate Gene Association

I would like to welcome breast cancer research community to the first editorial of our newest journal “Breast Cancer: Basic and Clinical Research”. In pursuit of breast cancer culprits, we have come a long way since the early 90's when the first breast cancer susceptibility gene BRCA1 was mapped and cloned. In the past few years, several new loci associated with the various degree of breast cancer risk have been identified using “Candidate Gene Association Study (CGAS) and Genome-Wide Association Study (GWAS)” approaches. This editorial is meant to quickly glance over recent findings of these population-based association studies.

scholarly journals Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62550 ◽  
Author(s):  
Yadav Sapkota ◽  
Yutaka Yasui ◽  
Raymond Lai ◽  
Malinee Sridharan ◽  
Paula J. Robson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
A Genome

scholarly journals Correlations of EZH2 and SMYD3 gene polymorphisms with breast cancer susceptibility and prognosis

2018 ◽  
Vol 38 (1) ◽  
Author(s):  
Shao-Jun Ma ◽  
Yan-Mei Liu ◽  
Yue-Lang Zhang ◽  
Ming-Wei Chen ◽  
Wei Cao
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Gene Polymorphisms ◽  
Tandem Repeats ◽  
Cancer Susceptibility ◽  
Menopausal Status ◽  
Breast Cancer Susceptibility ◽  
Clinical Staging ◽  
Her2 Status ◽  
Cancer Tissues

The aim of the present study was to investigate the correlation of enhancer of Zeste homolog 2 (EZH2) and SET and MYND domain containing 3 (SMYD3) gene polymorphisms with breast cancer susceptibility and prognosis. A total of 712 patients with breast cancer and 783 healthy individuals were selected. Normal breast epithelial cells MCF-10A and breast cancer cells MCF-7, MDA-MB-231, T47D, and Bcap-37 were cultured. Polymerase chain reaction (PCR)-restriction fragment length polymorphism method was applied for genotyping. Reverse-transcription quantitative PCR (RT-qPCR) and Western blotting were used to examine EZH2 and SMYD3 expression in breast cancer tissues and cells. The risk factors and prognostic factors for breast cancer were estimated. The C allele of EZH2 rs12670401 (odds ratio (OR) =1.255, 95% confidence interval (95% CI): 1.085–1.452), T allele of EZH2 rs6464926 (OR =1.240, 95% CI: 1.071–1.435), and three alleles of SMYD3 variable number of tandem repeats (VNTRs) (OR =1.305, 95% CI: 1.097–1.552) could increase susceptibility to breast cancer. Combined genotypes of EZH2 rs12670401 (TC + CC) and EZH2 rs6464926 (CT + TT) were associated with breast cancer susceptibility. Breast cancer tissues had higher EZH2 and SMYD3 expression. EZH2 rs12670401, EZH2 rs6464926, age of menarche, and menopausal status were associated with breast cancer susceptibility. Patients with TT genotype of EZH2 rs12670401 or with CC genotype of EZH2 rs6464926 had higher overall survival (OS). EZH2 rs12670401, EZH2 rs6464926, and clinical staging were independent prognostic factors for breast cancer. SMYD3 VNTR polymorphism exhibited no association with susceptibility and prognosis. EZH2 rs12670401 and rs6464926 polymorphisms, EZH2 and SMYD3 expression, clinical staging, lymph node metastasis, human epidermal growth factor receptor-2 (HER2) status, and metastasis may be correlated with breast cancer susceptibility and prognosis.

scholarly journals Genome-wide association study in East Asians identifies two novel breast cancer susceptibility loci

2016 ◽  
Vol 25 (15) ◽  
pp. 3361-3371 ◽  
Author(s):  
Mi-Ryung Han ◽  
Jirong Long ◽  
Ji-Yeob Choi ◽  
Siew-Kee Low ◽  
Sun-Seog Kweon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Breast Cancer Susceptibility ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
East Asians ◽  
Genome Wide
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