scholarly journals Endovascular Perforation Subarachnoid Hemorrhage Fails to Cause Morris Water Maze Deficits in the Mouse

2014 ◽  
Vol 34 (9) ◽  
pp. e1-e9 ◽  
Author(s):  
Eric Milner ◽  
Jacob C Holtzman ◽  
Stuart Friess ◽  
Richard E Hartman ◽  
David L Brody ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Morris Water Maze ◽  
Water Maze ◽  
Genetic Manipulation ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Cognitive Outcome ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Primary Driver

Cognitive dysfunction is the primary driver of poor long-term outcome in aneurysmal subarachnoid hemorrhage (SAH) survivors; modeling such deficits preclinically is thus key for mechanistic and translational investigation. Although rat SAH causes long-term deficits in learning and memory, it remains unknown whether similar deficits are seen in the mouse, a species particularly amenable to powerful, targeted genetic manipulation. We thus subjected mice to endovascular perforation SAH and assessed long-term cognitive outcome via the Morris water maze (MWM), the most commonly used metric for rodent neurocognition. No significant differences in MWM performance (by either of two protocols) were seen in SAH versus sham mice. Moreover, SAH caused negligible hippocampal CA1 injury. These results undercut the potential of commonly used methods (of SAH induction and assessment of long-term neurocognitive outcome) for use in targeted molecular studies of SAH-induced cognitive deficits in the mouse.

scholarly journals Assessment of the Subarachnoid Hemorrhage International Trialists (SAHIT) Models for Dichotomized Long-Term Functional Outcome Prediction After Aneurysmal Subarachnoid Hemorrhage in a United Kingdom Multicenter Cohort Study

Neurosurgery ◽  
2020 ◽  
Author(s):  
Isabel C Hostettler ◽  
Menelaos Pavlou ◽  
Gareth Ambler ◽  
Varinder S Alg ◽  
Stephen Bonner ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Functional Outcome ◽  
Outcome Prediction ◽  
Prediction Models ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Predictive Performance ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Fisher Grade

Abstract BACKGROUND Long-term outcome after subarachnoid hemorrhage, beyond the first few months, is difficult to predict, but has critical relevance to patients, their families, and carers. OBJECTIVE To assess the performance of the Subarachnoid Hemorrhage International Trialists (SAHIT) prediction models, which were initially designed to predict short-term (90 d) outcome, as predictors of long-term (2 yr) functional outcome after aneurysmal subarachnoid hemorrhage (aSAH). METHODS We included 1545 patients with angiographically-proven aSAH from the Genetic and Observational Subarachnoid Haemorrhage (GOSH) study recruited at 22 hospitals between 2011 and 2014. We collected data on age, WNFS grade on admission, history of hypertension, Fisher grade, aneurysm size and location, as well as treatment modality. Functional outcome was measured by the Glasgow Outcome Scale (GOS) with GOS 1 to 3 corresponding to unfavorable and 4 to 5 to favorable functional outcome, according to the SAHIT models. The SAHIT models were assessed for long-term outcome prediction by estimating measures of calibration (calibration slope) and discrimination (area under the receiver-operating characteristic curve [AUC]) in relation to poor clinical outcome. RESULTS Follow-up was standardized to 2 yr using imputation methods. All 3 SAHIT models demonstrated acceptable predictive performance for long-term functional outcome. The estimated AUC was 0.71 (95% CI: 0.65-0.76), 0.73 (95% CI: 0.68-0.77), and 0.74 (95% CI: 0.69-0.79) for the core, neuroimaging, and full models, respectively; the calibration slopes were 0.86, 0.84, and 0.89, indicating good calibration. CONCLUSION The SAHIT prediction models, incorporating simple factors available on hospital admission, show good predictive performance for long-term functional outcome after aSAH.

Cerebrospinal Fluid Concentrations of Nimodipine Correlate With Long-term Outcome in Aneurysmal Subarachnoid Hemorrhage

2019 ◽  
Vol 42 (5) ◽  
pp. 157-162 ◽  
Author(s):  
Roberto Riva ◽  
Marianna Pegoli ◽  
Manuela Contin ◽  
Alessandro Perrone ◽  
Susan Mohamed ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Term Outcome ◽  
Long Term Outcome

Long-term outcome after aneurysmal subarachnoid hemorrhage—risks of vascular events, death from cancer and all-cause death

2013 ◽  
Vol 261 (2) ◽  
pp. 309-315 ◽  
Author(s):  
Dennis J. Nieuwkamp ◽  
Arno de Wilde ◽  
Marieke J. H. Wermer ◽  
Ale Algra ◽  
Gabriël J. E. Rinkel
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Vascular Events ◽  
Term Outcome ◽  
Long Term Outcome

Pupillary Reactivity Upon Hospital Admission Predicts Long-term Outcome in Poor Grade Aneurysmal Subarachnoid Hemorrhage Patients

2007 ◽  
Vol 8 (3) ◽  
pp. 374-379 ◽  
Author(s):  
William J. Mack ◽  
Zachary L. Hickman ◽  
Andrew F. Ducruet ◽  
James T. Kalyvas ◽  
Matthew C. Garrett ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Hospital Admission ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Poor Grade ◽  
Pupillary Reactivity

Non-aneurysmal subarachnoid hemorrhage in 173 patients: a prospective study of long-term outcome

2015 ◽  
Vol 22 (10) ◽  
pp. 1329-1336 ◽  
Author(s):  
J. Konczalla ◽  
J. Schmitz ◽  
S. Kashefiolasl ◽  
C. Senft ◽  
V. Seifert ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Prospective Study ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Term Outcome ◽  
Long Term Outcome ◽  
A Prospective Study

scholarly journals Somatosensory evoked potentials in patients with high-grade aneurysmal subarachnoid hemorrhage

2017 ◽  
Vol 43 (5) ◽  
pp. E17
Author(s):  
Klaus Christian Mende ◽  
Mathias Gelderblom ◽  
Cindy Schwarz ◽  
Patrick Czorlich ◽  
Nils Ole Schmidt ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Clinical Outcome ◽  
Somatosensory Evoked Potentials ◽  
Tibial Nerve ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
High Grade ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cortical Responses

OBJECTIVEThe aim of this prospective study was to investigate the value of somatosensory evoked potentials (SEPs) in predicting outcome in patients with high-grade aneurysmal subarachnoid hemorrhage (SAH).METHODSBetween January 2013 and January 2015, 48 patients with high-grade SAH (Hunt and Hess Grade III, IV, or V) who were admitted within 3 days after hemorrhage were enrolled in the study. Right and left median and tibial nerve SEPs were recorded on Day 3 after hemorrhage and recorded again 2 weeks later. Glasgow Outcome Scale (GOS) scores were determined 6 months after hemorrhage and dichotomized as poor (Scores 1–3) or good (Scores 4–5). Results of SEP measurements were dichotomized (present or missing cortical responses or normal or prolonged latencies) for each nerve and side. These variables were summed and tested using logistic regression and a receiver operating characteristic curve to assess the value of SEPs in predicting long-term outcome.RESULTSAt the 6-month follow-up visit, 29 (60.4%) patients had a good outcome, and 19 (39.6%) had a poor outcome. The first SEP measurement did not correlate with clinical outcome (area under the curve [AUC] 0.69, p = 0.52). At the second measurement of median nerve SEPs, all patients with a good outcome had cortical responses present bilaterally, and none of them had bilateral prolonged latencies (p = 0.014 and 0.003, respectively). In tibial nerve SEPs, 7.7% of the patients with a good GOS score had one or more missing cortical responses, and bilateral prolonged latencies were found in 23% (p = 0.001 and 0.034, respectively). The second measurement correlated with the outcome regarding each of the median and tibial nerve SEPs and the combination of both (AUC 0.75 [p = 0.010], 0.793 [p = 0.003], and 0.81 [p = 0.001], respectively).CONCLUSIONSEarly SEP measurement after SAH did not correlate with clinical outcome, but measurement of median and tibial nerve SEPs 2 weeks after a hemorrhage did predict long-term outcome in patients with high-grade SAH.

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