scholarly journals Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster

Leukemia ◽  
2017 ◽  
Vol 31 (8) ◽  
pp. 1819-1821 ◽  
Author(s):  
G Cazzaniga ◽  
L Bisanti ◽  
G Randi ◽  
S Deandrea ◽  
S Bungaro ◽  
...  
Keyword(s):  
Childhood Leukemia ◽  
Swine Flu ◽  
Flu Virus

scholarly journals Influenza swine flu virus: A candidate for the next pandemic?

2021 ◽  
Vol 11 ◽  
Author(s):  
Mahnoor Yousif Shaikh ◽  
Farah Yasmin ◽  
Rohan Kumar Ochani ◽  
Syed Muhammad Ismail Shah
Keyword(s):  
Swine Flu ◽  
Flu Virus

scholarly journals Venous Thromboembolism in COVID-19

2020 ◽  
Vol 120 (12) ◽  
pp. 1642-1653 ◽  
Author(s):  
Sam Schulman ◽  
Yu Hu ◽  
Stavros Konstantinides
Keyword(s):  
Venous Thromboembolism ◽  
Potential Role ◽  
Treatment Guidelines ◽  
Swine Flu ◽  
Thrombolytic Treatment ◽  
Medically Ill ◽  
Risk Assessment Models ◽  
Consensus Statements ◽  
Medically Ill Patients

AbstractThe coronavirus disease 2019 (COVID-19) is our latest pandemic, preceded by the H1N1 swine flu in 2009, which lasted approximately 19 months. One of the special characteristics of COVID-19 is the propensity to cause venous thromboembolism (VTE). Thromboinflammation seems to play a prominent role in the pathogenesis. We will here review some mechanisms in the pathogenesis and discuss some hematological biomarkers, and also whether they serve as useful risk factors for VTE. The role of general risk assessment models for medically ill patients specifically in COVID-19 is appraised. The type of prophylaxis and particularly whether standard or augmented doses of chemoprophylaxis should be used is reviewed based on available evidence. We are also comparing recommendations from 10 different guidance or position/consensus statements. Treatment recommendations for patients with COVID-19 and pulmonary embolism are discussed with current general treatment guidelines as reference. Specifics for patients with COVID-19 are pointed out and the potential role of thrombolytic treatment is explored.

scholarly journals The role of the hotel industry in the response to emerging epidemics: a case study of SARS in 2003 and H1N1 swine flu in 2009 in Hong Kong

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Kevin K. C. Hung ◽  
Carman K. M. Mark ◽  
May P. S. Yeung ◽  
Emily Y. Y. Chan ◽  
Colin A. Graham
Keyword(s):  
Hong Kong ◽  
Hotel Industry ◽  
Swine Flu

scholarly journals Genetic variation in the folate metabolic pathway and risk of childhood leukemia

Blood ◽  
2010 ◽  
Vol 115 (19) ◽  
pp. 3923-3929 ◽  
Author(s):  
Tracy J. Lightfoot ◽  
W. Thomas Johnston ◽  
Dan Painter ◽  
Jill Simpson ◽  
Eve Roman ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Myeloid Leukemia ◽  
Childhood Leukemia ◽  
Lymphoblastic Leukemia ◽  
Folate Metabolism ◽  
The United Kingdom ◽  
Etiologic Role ◽  
Increased Risk ◽  
Metabolism Enzymes

Abstract Studies of childhood leukemia and the potential etiologic role of genetic variation in folate metabolism have produced conflicting findings and have often been based on small numbers. We investigated the association between polymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del6, and TS 28bp repeat) in 939 cases of childhood acute lymphoblastic leukemia (ALL) and 89 cases of acute myeloid leukemia (AML) recruited into the United Kingdom Childhood Cancer Study. We also examined the maternal genotypes of 752 of these cases. Data from 824 noncancer controls recruited were used for comparison. No evidence of an association with MTHFR 677 was observed for ALL or AML, either in children or their mothers. However, in children an increased risk of ALL (odds ratio [OR] = 1.88; 95% confidence interval [CI], 1.16-3.07; P = .010) and AML (OR = 2.74; 95% CI, 1.07-7.01; P = .036) was observed with the MTR 2756 GG genotype; the association was most pronounced for cases with the MLL translocation (OR = 4.90; 95% CI, 1.30-18.45; P = .019). These data suggest that genetic variation in methionine synthase could mediate risk of childhood leukemia, either via effects on DNA methylation or via effects on fetal growth and development.

scholarly journals Phylogenetic Analysis of H1N1 Swine Flu Virus Isolated In India

2011 ◽  
Vol 03 (01) ◽  
Author(s):  
Nutan Prakash ◽  
P. Devangi ◽  
K. Madhuuri ◽  
P. Khushbu ◽  
P. Deepali
Keyword(s):  
Phylogenetic Analysis ◽  
Swine Flu ◽  
Flu Virus

scholarly journals Implementation of Basic Local Alignment Search for Detection H1N1 Sequence Alignment

2019 ◽  
Vol 2 (1) ◽  
pp. 9
Author(s):  
Retno Tri Vulandari ◽  
Sri Siswanti ◽  
Andriani Kusumaningrum Kusumawijaya ◽  
Kumaratih Sandradewi
Keyword(s):  
Sequence Alignment ◽  
Dna Sequences ◽  
Molecular Data ◽  
Genome Project ◽  
Biological Information ◽  
Swine Flu ◽  
Local Alignment ◽  
Flu Virus ◽  
High Degree ◽  
Diverse Virus

Bioinformatics is a science that studies the management and analysis of biological information. Bioinformatics includes application of mathematics, statistics, and informatics to biological problems to solve. Bioinformatics can store data generated by the genome project with regular and high degree of accuracy. Basic local alignment search is one of the methods used to process penyejajaran molecular data sequences. In 2009, there is a virus that attacks the respiratory tract that is the swine flu. The virus is spread around the world, so that retrieved the journal research on diverse virus DNA sequences in different endemic countries. Therefore, in this study will be explained about the process sequence alignment of the H1N1 swine flu virus. H1N1 Weiss AF 250365.2 and H1N1 Swine AF250364.2 have 90% similarity level.

Role of Folylpolyglutamate Synthetase and Folylpolyglutamate Hydrolase in Methotrexate Accumulation and Polyglutamylation in Childhood Leukemia

Blood ◽  
1999 ◽  
Vol 93 (5) ◽  
pp. 1677-1683 ◽  
Author(s):  
Marianne G. Rots ◽  
Rob Pieters ◽  
Godefridus J. Peters ◽  
Paul Noordhuis ◽  
Christina H. van Zantwijk ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Multivariate Analysis ◽  
Myeloid Leukemia ◽  
Childhood Leukemia ◽  
Lymphoblastic Leukemia ◽  
Folylpolyglutamate Synthetase ◽  
Additional Role ◽  
Acute Myeloid

Abstract Inefficient polyglutamylation is a mechanism of resistance to methotrexate (MTX) in childhood T-lineage acute lymphoblastic leukemia (T-ALL) and in acute myeloid leukemia (AML) in comparison with childhood c/preB-ALL. We analyzed the profile of MTX polyglutamylation in childhood c/preB-ALL, T-ALL, and AML (n = 45, 15, and 14, respectively), the activity of the MTX-polyglutamate synthesizing enzyme folylpolyglutamate synthetase (FPGS) (n = 39, 11, and 19, respectively) and of the MTX-polyglutamate breakdown enzyme folylpolyglutamate hydrolase (FPGH) (n = 98, 25, and 34, respectively). MTX-Glu4-6 accumulation after 24 hours exposure to 1 μmol/L [3H]-MTX in vitro was lower in T-ALL (threefold) and AML (fourfold) compared with c/preB-ALL (P ≤ .001). The FPGS activity was twofold lower in T-ALL and AML than in c/preB-ALL samples (P < .01). FPGH activity was not different between c/preB-ALL and T-ALL, but threefold higher in AML (P < .001). FPGS, FPGH, and the ratio FPGS/FPGH were correlated with MTX-Glu4-6 accumulation (r = .49, r = −.34 and r = .61, respectively). Multivariate analysis showed that FPGS, but not FPGH, was an independent contributor for MTX-Glu1-6 accumulation, but not for MTX-Glu4-6 accumulation. In conclusion, low FPGS activity is associated with low accumulation of MTX-Glu4-6 in T-ALL and AML. For the group of AML as compared with the group of ALL, a high FPGH activity can play an additional role.

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