scholarly journals Inactivation of the E-Cadherin Gene in Sporadic Diffuse-Type Gastric Cancer

2001 ◽  
Vol 14 (10) ◽  
pp. 942-949 ◽  
Author(s):  
Jennifer J Ascaño ◽  
Henry Frierson ◽  
Christopher A Moskaluk ◽  
Jeffrey C Harper ◽  
Franco Roviello ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diffuse Type ◽  
Diffuse Type Gastric Cancer ◽  
E Cadherin

scholarly journals Analysis of E-Cadherin in Diffuse-Type Gastric Cancer Using a Mutation-Specific Monoclonal Antibody

1999 ◽  
Vol 155 (6) ◽  
pp. 1803-1809 ◽  
Author(s):  
Karl-Friedrich Becker ◽  
Elisabeth Kremmer ◽  
Manfred Eulitz ◽  
Ingrid Becker ◽  
Gabriele Handschuh ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Monoclonal Antibody ◽  
Specific Monoclonal Antibody ◽  
Diffuse Type ◽  
Diffuse Type Gastric Cancer ◽  
E Cadherin

Proposal for an international multi center study: E-cadherin mutationspecific antibody to detect exon deletion in diffuse type gastric cancer

1997 ◽  
Vol 33 ◽  
pp. S279
Author(s):  
C. Schuhmacher ◽  
K.-F. Becker ◽  
I. Becker ◽  
E. Kremmer ◽  
J.R. Siewert ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diffuse Type ◽  
Multi Center Study ◽  
Diffuse Type Gastric Cancer ◽  
Exon Deletion ◽  
Center Study ◽  
E Cadherin

Mutant E-cadherin as a new target for diagnosis and therapy of diffuse-type gastric cancer

1997 ◽  
Vol 33 ◽  
pp. S41
Author(s):  
Karl-Friedrich Becker ◽  
Ingrid Becker ◽  
Christoph Schuhmacher ◽  
Elisabeth Kremmer ◽  
Manfred Eulitz ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diffuse Type ◽  
Diagnosis And Therapy ◽  
Diffuse Type Gastric Cancer ◽  
E Cadherin

Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

Gut ◽  
2011 ◽  
Vol 61 (3) ◽  
pp. 344-353 ◽  
Author(s):  
Shu Shimada ◽  
Ayako Mimata ◽  
Masaki Sekine ◽  
Kaoru Mogushi ◽  
Yoshimitsu Akiyama ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mouse Model ◽  
Tumour Suppressor ◽  
Diffuse Type ◽  
Suppressor Activity ◽  
Tumour Suppressor Activity ◽  
Diffuse Type Gastric Cancer ◽  
Conditional Mouse Model ◽  
E Cadherin

scholarly journals Identification of Subtype-Specific Three-Gene Signature for Prognostic Prediction in Diffuse Type Gastric Cancer

2019 ◽  
Vol 9 ◽  
Author(s):  
Bowen Bao ◽  
Chunlei Zheng ◽  
Bowen Yang ◽  
Yue Jin ◽  
Kezuo Hou ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Signature ◽  
Diffuse Type ◽  
Prognostic Prediction ◽  
Diffuse Type Gastric Cancer

scholarly journals Molecular Network Profiling in Intestinal- and Diffuse-Type Gastric Cancer

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3833
Author(s):  
Shihori Tanabe ◽  
Sabina Quader ◽  
Ryuichi Ono ◽  
Horacio Cabral ◽  
Kazuhiko Aoyagi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Drug Resistance ◽  
Signaling Pathways ◽  
Pathway Analysis ◽  
Rna Binding ◽  
Binding Protein ◽  
Diffuse Type ◽  
Mesenchymal Transition ◽  
Diffuse Type Gastric Cancer

Epithelial-mesenchymal transition (EMT) plays an important role in the acquisition of cancer stem cell (CSC) feature and drug resistance, which are the main hallmarks of cancer malignancy. Although previous findings have shown that several signaling pathways are activated in cancer progression, the precise mechanism of signaling pathways in EMT and CSCs are not fully understood. In this study, we focused on the intestinal and diffuse-type gastric cancer (GC) and analyzed the gene expression of public RNAseq data to understand the molecular pathway regulation in different subtypes of gastric cancer. Network pathway analysis was performed by Ingenuity Pathway Analysis (IPA). A total of 2815 probe set IDs were significantly different between intestinal- and diffuse-type GC data in cBioPortal Cancer Genomics. Our analysis uncovered 10 genes including male-specific lethal 3 homolog (Drosophila) pseudogene 1 (MSL3P1), CDC28 protein kinase regulatory subunit 1B (CKS1B), DEAD-box helicase 27 (DDX27), golgi to ER traffic protein 4 (GET4), chromosome segregation 1 like (CSE1L), translocase of outer mitochondrial membrane 34 (TOMM34), YTH N6-methyladenosine RNA binding protein 1 (YTHDF1), ribonucleic acid export 1 (RAE1), par-6 family cell polarity regulator beta (PARD6B), and MRG domain binding protein (MRGBP), which have differences in gene expression between intestinal- and diffuse-type GC. A total of 463 direct relationships with three molecules (MYC, NTRK1, UBE2M) were found in the biomarker-filtered network generated by network pathway analysis. The networks and features in intestinal- and diffuse-type GC have been investigated and profiled in bioinformatics. Our results revealed the signaling pathway networks in intestinal- and diffuse-type GC, bringing new light for the elucidation of drug resistance mechanisms in CSCs.

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