scholarly journals Slit2–Robo4 signalling promotes vascular stability by blocking Arf6 activity

2009 ◽  
Vol 11 (11) ◽  
pp. 1325-1331 ◽  
Author(s):  
Christopher A. Jones ◽  
Naoyuki Nishiya ◽  
Nyall R. London ◽  
Weiquan Zhu ◽  
Lise K. Sorensen ◽  
...  
Keyword(s):  
Vascular Stability

scholarly journals Collagen COL22A1 maintains vascular stability and mutations in COL22A1 are potentially associated with intracranial aneurysms

2018 ◽  
Vol 11 (12) ◽  
pp. dmm033654 ◽  
Author(s):  
Quynh V. Ton ◽  
Daniel Leino ◽  
Sarah A. Mowery ◽  
Nina O. Bredemeier ◽  
Pascal J. Lafontant ◽  
...  
Keyword(s):  
Intracranial Aneurysms ◽  
Vascular Stability

scholarly journals Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling

2018 ◽  
Vol 38 (2) ◽  
pp. 353-362 ◽  
Author(s):  
Shlomo Krispin ◽  
Amber N. Stratman ◽  
Chase H. Melick ◽  
Radu V. Stan ◽  
Matteo Malinverno ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Signaling ◽  
Vascular Endothelial ◽  
Differentiation Factor ◽  
Vascular Stability ◽  
Endothelial Growth Factor

scholarly journals Mechanisms of vascular stability and the relationship to human disease

2010 ◽  
pp. 1 ◽  
Author(s):  
Matthew CP Smith ◽  
Dean Y Li ◽  
Kevin J Whitehead
Keyword(s):  
Human Disease ◽  
Vascular Stability ◽  
The Relationship

Abstract 23: Microrna302-367 Sphingosine 1 Phosphate Receptor 1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Enhancing Vascular Stability

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Jinjiang Pi ◽  
Ting Tao ◽  
Tao Zhuang ◽  
Huimin Sun ◽  
Xiaoli Chen ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Tumor Growth ◽  
Ex Vivo ◽  
Downstream Target ◽  
Sprouting Angiogenesis ◽  
Pathological Angiogenesis ◽  
Vascular Stability ◽  
Sphingosine 1 Phosphate

Angiogenic hypersprouting and leaky immature vessels of pathological angiogenesis are essential for tumor growth. MicroRNAs have unique therapeutic advantages by targeting multiple pathways of tumor-associated angiogenesis, but the function of individual miRNAs in angiogenesis and tumors has not yet been fully evaluated. Here, we show that miR302-367 elevation in endothelial cells reduces retina sprouting angiogenesis and promotes vascular stability in vivo, ex vivo and in vitro. Erk1/2 are identified as direct targets of miR302-367, and down-regulation of Erk1/2 upon miR302-367 elevation in endothelial cells increases the expression of Klf2 and in turn S1pr1 and its downstream target VE-cadherin, suppressing angiogenesis and improving vascular stability. Conversely, both pharmacological blockade and genetic deletion of S1pr1 in endothelial cells reverse the anti-angiogenic and vascular stabilizing effect of miR302-367 in mice. Pathological angiogenesis in tumors shares features of developmental angiogenesis, and endothelial specific elevation of miR302-367 reduces tumor growth by restricting sprout angiogenesis and decreasing vascular permeability via the same Erk1/2-Klf2-S1pr1 pathways. In conclusion, miR302-367 regulation of an Erk1/2-Klf2-S1pr1 pathway in the endothelium advances our understanding of angiogenesis, meanwhile also provides opportunities for therapeutic intervention of tumor growth.

scholarly journals Multimerin-2 maintains vascular stability and permeability

2020 ◽  
Vol 87 ◽  
pp. 11-25 ◽  
Author(s):  
Rosanna Pellicani ◽  
Evelina Poletto ◽  
Eva Andreuzzi ◽  
Alice Paulitti ◽  
Roberto Doliana ◽  
...  
Keyword(s):  
Vascular Stability

Can Vascular Stability Be Improved with Short Acetate Hemodialysis if Biocompatible Membranes Are Used?

2015 ◽  
pp. 214-217
Author(s):  
B. Branger ◽  
G. Deschodt ◽  
R. Oul�s ◽  
C. Granolleras ◽  
B. Alsabadani ◽  
...  
Keyword(s):  
Vascular Stability

scholarly journals Iatrogenic Aortic Transection in a Child

Aorta ◽  
2015 ◽  
Vol 03 (01) ◽  
pp. 38-40
Author(s):  
Ram Sherawat ◽  
Anil Sharma ◽  
Sunil Dixit ◽  
Mohit Sharma ◽  
Sidarth Lukaram
Keyword(s):  
Case Report ◽  
Abdominal Aorta ◽  
Positive Impact ◽  
Aortic Injury ◽  
Delayed Repair ◽  
Vascular Stability ◽  
Impact On Survival ◽  
Aortic Transection

AbstractThe accepted treatment for aortic injury has been repair of the injury as soon as possible. Delayed repair is not generally fruitful, but in our case report, delay in the repair of a ligated and transected abdominal aorta is safe and has a potential positive impact on survival and vascular stability/integrity. This case seems worth reporting.

Abstract C248: Targeting the tumor microenvironment: Vascular‐specific damage by tirapazamine influenced by hypoxia and vascular stability

2009 ◽  
Author(s):  
Jennifer H. E. Baker ◽  
Alastair H. Kyle ◽  
Erin Flannagan ◽  
Stephen Methot ◽  
Andrew Balbirnie ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Vascular Stability

Vascular Stability and Heat in Dialysis Patients

2015 ◽  
pp. 398-402 ◽  
Author(s):  
Q. Maggiore ◽  
F. Pizzarelli ◽  
S. Sisca ◽  
C. Catalano ◽  
D. Delfino
Keyword(s):  
Dialysis Patients ◽  
Vascular Stability

scholarly journals Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension

Blood ◽  
2011 ◽  
Vol 118 (15) ◽  
pp. 4274-4284 ◽  
Author(s):  
Feng Zhang ◽  
Jarett E. Michaelson ◽  
Simon Moshiach ◽  
Norman Sachs ◽  
Wenyuan Zhao ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Endothelial Cell ◽  
Cell Matrix ◽  
Vascular Morphogenesis ◽  
Vascular Stability ◽  
Optimal Functions ◽  
Cytoskeletal Tension ◽  
Cell Cell

Abstract Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathologic angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. Here we report that CD151 is required for maintaining endothelial capillary-like structures formed in vitro and the integrity of endothelial cell-cell and cell-matrix contacts in vivo. In addition, vascular permeability is markedly enhanced in the absence of CD151. As a global regulator of endothelial cell-cell and cell-matrix adhesions, CD151 is needed for the optimal functions of various cell adhesion proteins. The loss of CD151 elevates actin cytoskeletal traction by up-regulating RhoA signaling and diminishes actin cortical meshwork by down-regulating Rac1 activity. The inhibition of RhoA or activation of cAMP signaling stabilizes CD151-silenced or -null endothelial structure in vascular morphogenesis. Together, our data demonstrate that CD151 maintains vascular stability by promoting endothelial cell adhesions, especially cell-cell adhesion, and confining cytoskeletal tension.

Sign in / Sign up

Export Citation Format

Share Document