scholarly journals Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Hongmei Fu ◽  
Madhav Kishore ◽  
Beartice Gittens ◽  
Guosu Wang ◽  
David Coe ◽  
...  
2010 ◽  
Vol 23 (1-2) ◽  
pp. 45-52 ◽  
Author(s):  
Maria Teresa Gandolfo ◽  
Hye Ryoun Jang ◽  
Serena M. Bagnasco ◽  
Gang-Jee Ko ◽  
Patricia Agreda ◽  
...  

2012 ◽  
Vol 72 (21) ◽  
pp. 5473-5482 ◽  
Author(s):  
James P. Hindley ◽  
Emma Jones ◽  
Kathryn Smart ◽  
Hayley Bridgeman ◽  
Sarah N. Lauder ◽  
...  

2009 ◽  
Vol 131 ◽  
pp. S12
Author(s):  
Yair Fisher ◽  
Rona Baron ◽  
Anna Nemirovsky ◽  
Alon Monsonego

Blood ◽  
2009 ◽  
Vol 113 (24) ◽  
pp. 6138-6147 ◽  
Author(s):  
Audrey Gérard ◽  
Rob A. van der Kammen ◽  
Hans Janssen ◽  
Saskia I. Ellenbroek ◽  
John G. Collard

Abstract Migration toward chemoattractants is a hallmark of T-cell trafficking and is essential to produce an efficient immune response. Here, we have analyzed the function of the Rac activator Tiam1 in the control of T-cell trafficking and transendothelial migration. We found that Tiam1 is required for chemokine- and S1P-induced Rac activation and subsequent cell migration. As a result, Tiam1-deficient T cells show reduced chemotaxis in vitro, and impaired homing, egress, and contact hypersensitivity in vivo. Analysis of the T-cell transendothelial migration cascade revealed that PKCζ/Tiam1/Rac signaling is dispensable for T-cell arrest but is essential for the stabilization of polarization and efficient crawling of T cells on endothelial cells. T cells that lack Tiam1 predominantly transmigrate through individual endothelial cells (transcellular migration) rather than at endothelial junctions (paracellular migration), suggesting that T cells are able to change their route of transendothelial migration according to their polarization status and crawling capacity.


2021 ◽  
Vol 119 ◽  
pp. 102610
Author(s):  
Patricia Hamminger ◽  
Luca Marchetti ◽  
Teresa Preglej ◽  
René Platzer ◽  
Ci Zhu ◽  
...  

2011 ◽  
Vol 187 (5) ◽  
pp. 2067-2071 ◽  
Author(s):  
Deena L. Gibbons ◽  
Lucie Abeler-Dörner ◽  
Tim Raine ◽  
Il-Young Hwang ◽  
Anett Jandke ◽  
...  

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