Targets and dynamics of promoter DNA methylation during early mouse development

2010 ◽  
Vol 42 (12) ◽  
pp. 1093-1100 ◽  
Author(s):  
Julie Borgel ◽  
Sylvain Guibert ◽  
Yufeng Li ◽  
Hatsune Chiba ◽  
Dirk Schübeler ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mouse Development ◽  
Promoter Dna Methylation ◽  
Promoter Dna ◽  
Early Mouse

scholarly journals Thymoquinone Is a Multitarget Single Epidrug That Inhibits the UHRF1 Protein Complex

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 622
Author(s):  
Omeima Abdullah ◽  
Ziad Omran ◽  
Salman Hosawi ◽  
Ali Hamiche ◽  
Christian Bronner ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dna Methyltransferase ◽  
Ring Finger ◽  
Macromolecular Complex ◽  
Anticancer Activities ◽  
Histone Deacetylase 1 ◽  
Promoter Dna Methylation ◽  
New Gene ◽  
Regulatory Effects ◽  
Promoter Dna

Silencing of tumor suppressor genes (TSGs) through epigenetic mechanisms, mainly via abnormal promoter DNA methylation, is considered a main mechanism of tumorigenesis. The abnormal DNA methylation profiles are transmitted from the cancer mother cell to the daughter cells through the involvement of a macromolecular complex in which the ubiquitin-like containing plant homeodomain (PHD), and an interesting new gene (RING) finger domains 1 (UHRF1), play the role of conductor. Indeed, UHRF1 interacts with epigenetic writers, such as DNA methyltransferase 1 (DNMT1), histone methyltransferase G9a, erasers like histone deacetylase 1 (HDAC1), and functions as a hub protein. Thus, targeting UHRF1 and/or its partners is a promising strategy for epigenetic cancer therapy. The natural compound thymoquinone (TQ) exhibits anticancer activities by targeting several cellular signaling pathways, including those involving UHRF1. In this review, we highlight TQ as a potential multitarget single epidrug that functions by targeting the UHRF1/DNMT1/HDAC1/G9a complex. We also speculate on the possibility that TQ might specifically target UHRF1, with subsequent regulatory effects on other partners.

scholarly journals Cellular Heterogeneity–Adjusted cLonal Methylation (CHALM) improves prediction of gene expression

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianfeng Xu ◽  
Jiejun Shi ◽  
Xiaodong Cui ◽  
Ya Cui ◽  
Jingyi Jessica Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Cellular Heterogeneity ◽  
Biological Functions ◽  
Global Correlation ◽  
Differentially Methylated Genes ◽  
Promoter Dna Methylation ◽  
Functional Consequences ◽  
Promoter Dna ◽  
Underlying Mechanisms

AbstractPromoter DNA methylation is a well-established mechanism of transcription repression, though its global correlation with gene expression is weak. This weak correlation can be attributed to the failure of current methylation quantification methods to consider the heterogeneity among sequenced bulk cells. Here, we introduce Cell Heterogeneity–Adjusted cLonal Methylation (CHALM) as a methylation quantification method. CHALM improves understanding of the functional consequences of DNA methylation, including its correlations with gene expression and H3K4me3. When applied to different methylation datasets, the CHALM method enables detection of differentially methylated genes that exhibit distinct biological functions supporting underlying mechanisms.

P.0169 Parvalbumin (PVALB) promoter dna methylation association with early-life trauma in first episode psychosis patients

2021 ◽  
Vol 53 ◽  
pp. S122
Author(s):  
H. Fachim ◽  
C. Loureiro ◽  
F. Corsi-Zuelli ◽  
P. Rossi-Menezes ◽  
P. Louzada-Jr ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Early Life ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
Promoter Dna Methylation ◽  
Early Life Trauma ◽  
Promoter Dna

scholarly journals P2.01-007 Detection of Promoter DNA Methylation of APC, DAPK, and GSTP1 Genes in Tissue Biopsy and Matched Serum of Advanced Stage Lung Cancer Patients

2017 ◽  
Vol 12 (1) ◽  
pp. S787
Author(s):  
Ashraf Ansari ◽  
Sachin Kumar ◽  
Vinod Kakaria ◽  
Anant Mohan ◽  
Kalpana Luthra ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Methylation ◽  
Cancer Patients ◽  
Advanced Stage ◽  
Lung Cancer Patients ◽  
Promoter Dna Methylation ◽  
Promoter Dna ◽  
Advanced Stage Lung Cancer ◽  
Gstp1 Genes ◽  
Stage Lung Cancer

scholarly journals MGMT is down-regulated independently of promoter DNA methylation in rats with all-trans retinoic acid-induced spina bifida aperta

2019 ◽  
Vol 14 (2) ◽  
pp. 361 ◽  
Author(s):  
Zheng-Wei Yuan ◽  
He-Nan Zhang ◽  
Yi Guo ◽  
Wei Ma ◽  
Jia Xue ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Retinoic Acid ◽  
Spina Bifida ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Spina Bifida Aperta ◽  
Promoter Dna Methylation ◽  
Promoter Dna
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