scholarly journals ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

2008 ◽  
Vol 9 (10) ◽  
pp. 1131-1139 ◽  
Author(s):  
Takeshi Egawa ◽  
Dan R Littman
Keyword(s):  
T Cell ◽  
Cell Lineage ◽  
Cytotoxic T Cell ◽  
Helper T Cell

scholarly journals Gamma gene rearrangement and expression in autoreactive helper T cells.

1986 ◽  
Vol 163 (5) ◽  
pp. 1314-1318 ◽  
Author(s):  
M Zauderer ◽  
A Iwamoto ◽  
T W Mak
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Class Ii ◽  
Cytotoxic T Cell ◽  
Specific Class ◽  
Helper T Cell ◽  
Autoreactive T Cell ◽  
Cell Clones ◽  
Class Ii Mhc ◽  
T Cell Lines

gamma gene rearrangements similar to those described for cytotoxic T cell lines are found in L3T4+, autoreactive, or KLH-specific cloned helper T cell lines. High levels of gamma RNA transcripts were, in addition, detected in four out of five L3T4+, class II MHC-specific, autoreactive T cell clones, and in at least one of three KLH-specific, class II MHC-restricted clones. This contrasts with previously reported (9) expression of gamma RNA in only 1 of 11 antigen-specific helper T cell lines.

Functional commitment to helper T cell lineage precedes positive selection and is independent of T cell receptor MHC specificity

Immunity ◽  
1994 ◽  
Vol 1 (4) ◽  
pp. 269-276 ◽  
Author(s):  
Paola Corbella ◽  
Demetrius Moskophidis ◽  
Eugenia Spanopoulou ◽  
Clio Mamalaki ◽  
Mauro Tolaini ◽  
...  
Keyword(s):  
T Cell ◽  
Positive Selection ◽  
T Cell Receptor ◽  
Cell Lineage ◽  
Cell Receptor ◽  
Helper T Cell

scholarly journals The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage

2017 ◽  
Vol 18 (8) ◽  
pp. 931-939 ◽  
Author(s):  
Qiang Shan ◽  
Zhouhao Zeng ◽  
Shaojun Xing ◽  
Fengyin Li ◽  
Stacey M Hartwig ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factor ◽  
T Cell ◽  
Cell Lineage ◽  
Effector T Cells ◽  
Helper T Cell ◽  
Follicular Helper ◽  
Follicular Helper T Cell

scholarly journals Designing of Cytotoxic and Helper T Cell Epitope Map Provides Insights into the Highly Contagious Nature of the Pandemic Novel Coronavirus SARS-CoV2

2020 ◽  
Author(s):  
Seema Mishra
Keyword(s):  
T Cell ◽  
Subunit Vaccine ◽  
Cell Epitope ◽  
Cytotoxic T Cell ◽  
Diagnostic Tools ◽  
T Cell Epitope ◽  
T Cell Epitopes ◽  
Helper T Cell ◽  
Contagious Nature ◽  
Novel Coronavirus

This study provides key insights into the contagious nature of SARS-CoV2 through analyses of T cell epitopes designed from SARS-CoV2 proteome. All top-scoring cytotoxic T cell epitopes from ORF1ab and helper T cell epitopes identified from all proteins were utilized to provide crucial insights into its pathogenesis. These T cell epitopes can be used as prophylactic or therapeutic multi-subunit vaccine or as diagnostic tools.<br>

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