scholarly journals Chronic, wireless recordings of large-scale brain activity in freely moving rhesus monkeys

2014 ◽  
Vol 11 (6) ◽  
pp. 670-676 ◽  
Author(s):  
David A Schwarz ◽  
Mikhail A Lebedev ◽  
Timothy L Hanson ◽  
Dragan F Dimitrov ◽  
Gary Lehew ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Large Scale ◽  
Brain Activity ◽  
Freely Moving

scholarly journals Decoding brain activity using a large-scale probabilistic functional-anatomical atlas of human cognition

2016 ◽  
Author(s):  
Timothy N. Rubin ◽  
Oluwasanmi Koyejo ◽  
Krzysztof J. Gorgolewski ◽  
Michael N. Jones ◽  
Russell A. Poldrack ◽  
...  
Keyword(s):  
Large Scale ◽  
Latent Dirichlet Allocation ◽  
Topic Model ◽  
Brain Activity ◽  
Human Cognition ◽  
Brain Images ◽  
Whole Brain ◽  
Context Sensitive ◽  
Cognitive States ◽  
Small Set

AbstractA central goal of cognitive neuroscience is to decode human brain activity--i.e., to infer mental processes from observed patterns of whole-brain activation. Previous decoding efforts have focused on classifying brain activity into a small set of discrete cognitive states. To attain maximal utility, a decoding framework must be open-ended, systematic, and context-sensitive--i.e., capable of interpreting numerous brain states, presented in arbitrary combinations, in light of prior information. Here we take steps towards this objective by introducing a Bayesian decoding framework based on a novel topic model---Generalized Correspondence Latent Dirichlet Allocation---that learns latent topics from a database of over 11,000 published fMRI studies. The model produces highly interpretable, spatially-circumscribed topics that enable flexible decoding of whole-brain images. Importantly, the Bayesian nature of the model allows one to “seed” decoder priors with arbitrary images and text--enabling researchers, for the first time, to generative quantitative, context-sensitive interpretations of whole-brain patterns of brain activity.

scholarly journals Orientation and color tuning of the human visual gamma rhythm

2021 ◽  
Author(s):  
Ye Li ◽  
William Bosking ◽  
Michael S Beauchamp ◽  
Sameer A Sheth ◽  
Daniel Yoshor ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Large Scale ◽  
Brain Activity ◽  
Population Level ◽  
Gamma Oscillations ◽  
Cell Orientation ◽  
Population Activity ◽  
Color Tuning ◽  
Human Visual Cortex ◽  
Gamma Rhythm

Narrowband gamma oscillations (NBG: ~20-60Hz) in visual cortex reflect rhythmic fluctuations in population activity generated by underlying circuits tuned for stimulus location, orientation, and color. Consequently, the amplitude and frequency of induced NBG activity is highly sensitive to these stimulus features. For example, in the non-human primate, NBG displays biases in orientation and color tuning at the population level. Such biases may relate to recent reports describing the large-scale organization of single-cell orientation and color tuning in visual cortex, thus providing a potential bridge between measurements made at different scales. Similar biases in NBG population tuning have been predicted to exist in the human visual cortex, but this has yet to be fully examined. Using intracranial recordings from human visual cortex, we investigated the tuning of NBG to orientation and color, both independently and in conjunction. NBG was shown to display a cardinal orientation bias (horizontal) and also an end- and mid-spectral color bias (red/blue and green). When jointly probed, the cardinal bias for orientation was attenuated and an end-spectral preference for red and blue predominated. These data both elaborate on the close, yet complex, link between the population dynamics driving NBG oscillations and known feature selectivity biases in visual cortex, adding to a growing set of stimulus dependencies associated with the genesis of NBG. Together, these two factors may provide a fruitful testing ground for examining multi-scale models of brain activity, and impose new constraints on the functional significance of the visual gamma rhythm.

scholarly journals Neural Excursions from Low-Dimensional Manifold Structure Explain Intersubject Variation in Human Motor Learning

2021 ◽  
Author(s):  
Corson N Areshenkoff ◽  
Daniel J Gale ◽  
Joe Y Nashed ◽  
Dominic Standage ◽  
John Randall Flanagan ◽  
...  
Keyword(s):  
Motor Learning ◽  
Large Scale ◽  
Brain Activity ◽  
Dimensional Subspace ◽  
Learning Performance ◽  
Dimensional Manifold ◽  
Learning Abilities ◽  
Manifold Structure ◽  
Electrophysiological Studies ◽  
Low Dimensional

Humans vary greatly in their motor learning abilities, yet little is known about the neural mechanisms that underlie this variability. Recent neuroimaging and electrophysiological studies demonstrate that large-scale neural dynamics inhabit a low-dimensional subspace or manifold, and that learning is constrained by this intrinsic manifold architecture. Here we asked, using functional MRI, whether subject-level differences in neural excursion from manifold structure can explain differences in learning across participants. We had subjects perform a sensorimotor adaptation task in the MRI scanner on two consecutive days, allowing us to assess their learning performance across days, as well as continuously measure brain activity. We find that the overall neural excursion from manifold activity in both cognitive and sensorimotor brain networks is associated with differences in subjects' patterns of learning and relearning across days. These findings suggest that off-manifold activity provides an index of the relative engagement of different neural systems during learning, and that intersubject differences in patterns of learning and relearning across days are related to reconfiguration processes in cognitive and sensorimotor networks during learning.

scholarly journals Amelioration of the acute cardiovascular effects of cocaine by a longer acting mutant cocaine esterase in freely moving rhesus monkeys

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Gregory Thomas Collins ◽  
Kathy Ann Carey ◽  
Mei‐Chuan Ko
Keyword(s):  
Rhesus Monkeys ◽  
Cardiovascular Effects ◽  
Freely Moving ◽  
Cocaine Esterase

scholarly journals A novel neural prosthesis providing long-term electrocorticography recording and cortical stimulation for epilepsy and brain-computer interface

2019 ◽  
Vol 130 (4) ◽  
pp. 1166-1179 ◽  
Author(s):  
Pantaleo Romanelli ◽  
Marco Piangerelli ◽  
David Ratel ◽  
Christophe Gaude ◽  
Thomas Costecalde ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Large Scale ◽  
Brain Activity ◽  
Threshold Value ◽  
Time Span ◽  
Cortical Stimulation ◽  
Neural Prosthesis ◽  
Lower Limbs ◽  
Custom Made

OBJECTIVEWireless technology is a novel tool for the transmission of cortical signals. Wireless electrocorticography (ECoG) aims to improve the safety and diagnostic gain of procedures requiring invasive localization of seizure foci and also to provide long-term recording of brain activity for brain-computer interfaces (BCIs). However, no wireless devices aimed at these clinical applications are currently available. The authors present the application of a fully implantable and externally rechargeable neural prosthesis providing wireless ECoG recording and direct cortical stimulation (DCS). Prolonged wireless ECoG monitoring was tested in nonhuman primates by using a custom-made device (the ECoG implantable wireless 16-electrode [ECOGIW-16E] device) containing a 16-contact subdural grid. This is a preliminary step toward large-scale, long-term wireless ECoG recording in humans.METHODSThe authors implanted the ECOGIW-16E device over the left sensorimotor cortex of a nonhuman primate (Macaca fascicularis), recording ECoG signals over a time span of 6 months. Daily electrode impedances were measured, aiming to maintain the impedance values below a threshold of 100 KΩ. Brain mapping was obtained through wireless cortical stimulation at fixed intervals (1, 3, and 6 months). After 6 months, the device was removed. The authors analyzed cortical tissues by using conventional histological and immunohistological investigation to assess whether there was evidence of damage after the long-term implantation of the grid.RESULTSThe implant was well tolerated; no neurological or behavioral consequences were reported in the monkey, which resumed his normal activities within a few hours of the procedure. The signal quality of wireless ECoG remained excellent over the 6-month observation period. Impedance values remained well below the threshold value; the average impedance per contact remains approximately 40 KΩ. Wireless cortical stimulation induced movements of the upper and lower limbs, and elicited fine movements of the digits as well. After the monkey was euthanized, the grid was found to be encapsulated by a newly formed dural sheet. The grid removal was performed easily, and no direct adhesions of the grid to the cortex were found. Conventional histological studies showed no cortical damage in the brain region covered by the grid, except for a single microscopic spot of cortical necrosis (not visible to the naked eye) in a region that had undergone repeated procedures of electrical stimulation. Immunohistological studies of the cortex underlying the grid showed a mild inflammatory process.CONCLUSIONSThis preliminary experience in a nonhuman primate shows that a wireless neuroprosthesis, with related long-term ECoG recording (up to 6 months) and multiple DCSs, was tolerated without sequelae. The authors predict that epilepsy surgery could realize great benefit from this novel prosthesis, providing an extended time span for ECoG recording.

General Relativity and Cosmology

2020 ◽  
pp. 227-360
Author(s):  
P. J. E. Peebles
Keyword(s):  
Constant Velocity ◽  
Large Scale ◽  
Reference Frames ◽  
Physical Sciences ◽  
Inertial Frames ◽  
Moving Body ◽  
History Of ◽  
The Subject ◽  
Freely Moving ◽  
The Universe

This chapter discusses the development of physical sciences in seemingly chaotic ways, by paths that are at best dimly seen at the time. It refers to the history of ideas as an important part of any science, and particularly worth examining in cosmology, where the subject has evolved over several generations. It also examines the puzzle of inertia, which traces the connection to Albert Einstein's bold idea that the universe is homogeneous in the large-scale average called “cosmological principle.” The chapter cites Newtonian mechanics that defines a set of preferred motions in space, the inertial reference frames, by the condition that a freely moving body has a constant velocity. It talks about Ernst Mach, who argued that inertial frames are determined relative to the motion of the rest of the matter in the universe.

Opioidergic System and Functional Architecture of Intrinsic Brain Activity: Implications for Psychiatric Disorders

2020 ◽  
Vol 26 (4) ◽  
pp. 343-358
Author(s):  
Giulio Rocchi ◽  
Bruno Sterlini ◽  
Samuele Tardito ◽  
Matilde Inglese ◽  
Anna Corradi ◽  
...  
Keyword(s):  
Psychiatric Disorders ◽  
Opioid Receptors ◽  
Large Scale ◽  
Brain Activity ◽  
Subcortical Structures ◽  
Opioidergic System ◽  
Sensorimotor Network ◽  
Cortical Areas ◽  
High Doses ◽  
Intrinsic Brain Activity

The opioidergic system and intrinsic brain activity, as organized in large-scale networks such as the salience network (SN), sensorimotor network (SMN), and default-mode network (DMN), play core roles in healthy behavior and psychiatric disorders. This work aimed to investigate how opioidergic signaling affects intrinsic brain activity in healthy individuals by reviewing relevant neuroanatomical, molecular, functional, and pharmacological magnetic resonance imaging studies in order to clarify their physiological links and changes in psychiatric disorders. The SN shows dense opioidergic innervations of subcortical structures and high expression levels of opioid receptors in subcortical-cortical areas, with enhanced or reduced activity with low or very high doses of opioids, respectively. The SMN shows high levels of opioid receptors in subcortical areas and functional disconnection caused by opioids. The DMN shows low levels of opioid receptors in cortical areas and inhibited or enhanced activity with low or high doses of opioids, respectively. Finally, we proposed a working model. Opioidergic signaling enhances SN and suppresses SMN (and DMN) activity, resulting in affective excitation with psychomotor inhibition; stronger increases in opioidergic signaling attenuate the SN and SMN while disinhibiting the DMN, dissociating affective and psychomotor functions from the internal states; the opposite occurs with a deficit of opioidergic signaling.

scholarly journals Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 607 ◽  
Author(s):  
Daniëlle Copmans ◽  
Sara Kildgaard ◽  
Silas A. Rasmussen ◽  
Monika Ślęzak ◽  
Nina Dirkx ◽  
...  
Keyword(s):  
Large Scale ◽  
Brain Activity ◽  
Isoquinoline Alkaloids ◽  
Seizure Duration ◽  
Larval Zebrafish ◽  
The North ◽  
Structural Analogues ◽  
The North Sea ◽  
Large Scale Screening ◽  
The Eu

There is a high need for the development of new and improved antiseizure drugs (ASDs) to treat epilepsy. Despite the potential of marine natural products (MNPs), the EU marine biodiscovery consortium PharmaSea has made the only effort to date to perform ASD discovery based on large-scale screening of MNPs. To this end, the embryonic zebrafish photomotor response assay and the larval zebrafish pentylenetetrazole (PTZ) model were used to screen MNP extracts for neuroactivity and antiseizure activity, respectively. Here we report the identification of the two known isoquinoline alkaloids TMC-120A and TMC-120B as novel antiseizure compounds, which were isolated by bioactivity-guided purification from the marine-derived fungus Aspergillus insuetus. TMC-120A and TMC-120B were observed to significantly lower PTZ-induced seizures and epileptiform brain activity in the larval zebrafish PTZ seizure model. In addition, their structural analogues TMC-120C, penicisochroman G, and ustusorane B were isolated and also significantly lowered PTZ-induced seizures. Finally, TMC-120A and TMC-120B were investigated in a mouse model of drug-resistant focal seizures. Compound treatment significantly shortened the seizure duration, thereby confirming their antiseizure activity. These data underscore the possibility to translate findings in zebrafish to mice in the field of epilepsy and the potential of the marine environment for ASD discovery.

Behavioral effects of telestimulating hypothalamic reinforcement sites in freely moving rhesus monkeys

1972 ◽  
Vol 42 (2) ◽  
pp. 243-262 ◽  
Author(s):  
Peter Edward Maxim
Keyword(s):  
Rhesus Monkeys ◽  
Behavioral Effects ◽  
Freely Moving
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