Transcriptional networks regulating neuronal identity in the developing spinal cord

10.1038/nn750 ◽  
2001 ◽  
Vol 4 (S11) ◽  
pp. 1183-1191 ◽  
Author(s):  
Soo-Kyung Lee ◽  
Samuel L. Pfaff
Keyword(s):  
Spinal Cord ◽  
Transcriptional Networks ◽  
Neuronal Identity ◽  
Developing Spinal Cord

scholarly journals Onecut factors and Pou2f2 regulate the distribution of V2 interneurons in the mouse developing spinal cord

2018 ◽  
Author(s):  
Audrey Harris ◽  
Gauhar Masgutova ◽  
Amandine Collin ◽  
Mathilde Toch ◽  
Maria Hidalgo-Figueroa ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Transcription Factors ◽  
Neural Circuits ◽  
B Cell Differentiation ◽  
Loss Of Function ◽  
Neuronal Identity ◽  
Spinal Interneuron ◽  
Embryonic Spinal Cord ◽  
And Migration ◽  
Developing Spinal Cord

AbstractAcquisition of proper neuronal identity and position is critical for the formation of neural circuits. In the embryonic spinal cord, cardinal populations of interneurons diversify into specialized subsets and migrate to defined locations within the spinal parenchyma. However, the factors that control interneuron diversification and migration remain poorly characterized. Here, we show that the Onecut transcription factors are necessary for proper diversification and distribution of the V2 interneurons in the developing spinal cord. Furthermore, we uncover that these proteins restrict and moderate the expression of spinal isoforms of Pou2f2, a transcription factor known to regulate B-cell differentiation. By gain- or loss-of-function experiments, we show that Pou2f2 contribute to regulate the position of V2 populations in the developing spinal cord. Thus, we uncovered a genetic pathway that regulates the diversification and the distribution of V2 interneurons during embryonic development.Significance statementIn this study, we identify the Onecut and Pou2f2 transcription factors as regulators of spinal interneuron diversification and migration, two events that are critical for proper CNS development.

scholarly journals Dorsal commissural axon guidance in the developing spinal cord

2020 ◽  
Author(s):  
Sandy Alvarez ◽  
Supraja G. Varadarajan ◽  
Samantha J. Butler
Keyword(s):  
Spinal Cord ◽  
Axon Guidance ◽  
Commissural Axon ◽  
Developing Spinal Cord

scholarly journals Expression and Cellular Distribution of Ubiquitin in Response to Injury in the Developing Spinal Cord of Monodelphis domestica

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62120 ◽  
Author(s):  
Natassya M. Noor ◽  
Kjeld Møllgård ◽  
Benjamin J. Wheaton ◽  
David L. Steer ◽  
Jessie S. Truettner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Monodelphis Domestica ◽  
Cellular Distribution ◽  
Developing Spinal Cord

scholarly journals Minocycline attenuates ethanol-induced cell death and microglial activation in the developing spinal cord

Alcohol ◽  
2019 ◽  
Vol 79 ◽  
pp. 25-35 ◽  
Author(s):  
Zhenhua Ren ◽  
Xin Wang ◽  
Mei Xu ◽  
Jacqueline A. Frank ◽  
Jia Luo
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Microglial Activation ◽  
Developing Spinal Cord

scholarly journals Daam2 Is Required for Dorsal Patterning via Modulation of Canonical Wnt Signaling in the Developing Spinal Cord

2012 ◽  
Vol 22 (1) ◽  
pp. 183-196 ◽  
Author(s):  
Hyun Kyoung Lee ◽  
Benjamin Deneen
Keyword(s):  
Spinal Cord ◽  
Wnt Signaling ◽  
Canonical Wnt Signaling ◽  
Canonical Wnt ◽  
Developing Spinal Cord

scholarly journals Do neurons from the primary motor cortex grow in response to signals from the developing spinal cord in vitro?

2015 ◽  
Author(s):  
F Alhumaid ◽  
S Almutairi ◽  
P Roach ◽  
HR Fuller ◽  
MA Gates
Keyword(s):  
Spinal Cord ◽  
Motor Cortex ◽  
Primary Motor Cortex ◽  
Developing Spinal Cord
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