scholarly journals The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder

2017 ◽  
Vol 43 (5) ◽  
pp. 1128-1137 ◽  
Author(s):  
Xiao Xiao ◽  
Fanfan Zheng ◽  
Hong Chang ◽  
Yina Ma ◽  
Yong-Gang Yao ◽  
...  

2021 ◽  
Vol 18 (12) ◽  
pp. 2005-2011
Author(s):  
Sirpi Nackeeran ◽  
Amoghavarsha Havanur ◽  
Jesse Ory ◽  
Stanley Althof ◽  
Ranjith Ramasamy


2009 ◽  
Vol 249 (2) ◽  
pp. 354
Author(s):  
Laurel A. Copeland ◽  
Valerie A. Lawrence ◽  
John E. Zeber


Cephalalgia ◽  
2015 ◽  
Vol 36 (5) ◽  
pp. 493-498 ◽  
Author(s):  
Jong-Geun Seo ◽  
Sung-Pa Park

Background Almost one-third of patients with migraine do not adequately respond to triptans. We examined factors contributing to frovatriptan response in patients with migraine. Methods We enrolled new patients with migraine who consecutively visited our headache clinic. Eligible patients were instructed to take 2.5 mg of frovatriptan as soon as possible after migraine attack. The responsiveness was determined by whether headache was relieved or absent within 4 hours after the intake of frovatriptan. We assessed frovatriptan to be efficacious when headache responded to its administration in at least one of two successive migraine attacks and inefficacious when headache was not relieved in either attack. We included demographic, clinical and psychiatric variables in the analysis of factors associated with frovatriptan response. Results Of 128 eligible patients, 28 (21.9%) experienced frovatriptan inefficacy. In 24 patients with current major depressive disorder, 12 (50.0%) had frovatriptan inefficacy. Only current major depressive disorder was identified as a risk factor for inefficacy (odds ratio = 5.500, 95% confidence interval 2.103–14.382, p = 0.001). Conclusions Depression may be a risk factor of frovatriptan inefficacy in patients with migraine, even though half of patients with major depressive disorder respond to frovatriptan.





2009 ◽  
Vol 14 (7) ◽  
pp. 650-652 ◽  
Author(s):  
Z Bochdanovits ◽  
M Verhage ◽  
A B Smit ◽  
E J C de Geus ◽  
D Posthuma ◽  
...  


2008 ◽  
Vol 193 (4) ◽  
pp. 322-326 ◽  
Author(s):  
Julie A. Pasco ◽  
Lana J. Williams ◽  
Felice N. Jacka ◽  
Felicity Ng ◽  
Margaret J. Henry ◽  
...  

BackgroundSmoking is disproportionately prevalent among people with psychiatric illness.AimsTo investigate smoking as a risk factor for major depressive disorder.MethodA population-based sample of women was studied using case–control and retrospective cohort study designs. Exposure to smoking was self-reported, and major depressive disorder diagnosed using the Structured Clinical Interview for DSM–IV–TR (SCID–I/NP).ResultsAmong 165 people with major depressive disorder and 806 controls, smoking was associated with increased odds for major depressive disorder (age-adjusted odds ratio (OR)=1.46, 95% CI 1.03–2.07). Compared with non-smokers, odds for major depressive disorder more than doubled for heavy smokers (>20 cigarettes/day). Among 671 women with no history of major depressive disorder at baseline, 13 of 87 smokers and 38 of 584 non-smokers developedde novomajor depressive disorder during a decade of follow-up. Smoking increased major depressive disorder risk by 93% (hazard ratio (HR)=1.93, 95% CI 1.02–3.69); this was not explained by physical activity or alcohol consumption.ConclusionsEvidence from cross-sectional and longitudinal data suggests that smoking increases the risk of major depressive disorder in women.



2014 ◽  
Vol 83 (5) ◽  
pp. 279-288 ◽  
Author(s):  
Lynn Boschloo ◽  
Robert A. Schoevers ◽  
Aartjan T.F. Beekman ◽  
Johannes H. Smit ◽  
Albert M. van Hemert ◽  
...  


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