scholarly journals Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo

Oncogenesis ◽  
2018 ◽  
Vol 7 (11) ◽  
Author(s):  
Seung-Shick Shin ◽  
Byeong-Seon Jeong ◽  
Brian A. Wall ◽  
Jiadong Li ◽  
Naing Lin Shan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation In Vitro

Low-intensity ultrasound inhibits melanoma cell proliferation in vitro and tumor growth in vivo

2021 ◽  
Author(s):  
Loreto B. Feril ◽  
Kazuki Yamaguchi ◽  
Yurika Ikeda-Dantsuji ◽  
Yukihiro Furusawa ◽  
Yoshiaki Tabuchi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Melanoma Cell ◽  
Low Intensity ◽  
Melanoma Cell Proliferation ◽  
Low Intensity Ultrasound ◽  
Proliferation In Vitro

Increased expression of MAP2 inhibits melanoma cell proliferation, invasion and tumor growth in vitro and in vivo

2010 ◽  
Vol 19 (11) ◽  
pp. 958-964 ◽  
Author(s):  
Zhiqi Song ◽  
Chun-Di He ◽  
Changkai Sun ◽  
Yanni Xu ◽  
Xin Jin ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation

scholarly journals Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Mélissa Labelle-Côté ◽  
Julie Dusseault ◽  
Salma Ismaïl ◽  
Aude Picard-Cloutier ◽  
Peter M Siegel ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Growth ◽  
Melanoma Cell ◽  
Primary Melanoma ◽  
Human Melanoma ◽  
Human Melanoma Cell ◽  
Migration And Invasion ◽  
Melanoma Cell Proliferation

scholarly journals Nuclear Localization of BRAFV600E Is Associated with HMOX-1 Upregulation and Aggressive Behavior of Melanoma Cells

Cancers ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 311
Author(s):  
Mourad Zerfaoui ◽  
Eman Toraih ◽  
Emmanuelle Ruiz ◽  
Youssef Errami ◽  
Abdallah S. Attia ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Nuclear Localization ◽  
Melanoma Cell ◽  
Braf Inhibitor ◽  
Melanoma Cells ◽  
Heme Oxygenase 1 ◽  
Biological Targets ◽  
Melanoma Cell Proliferation

Background: Previously, we have demonstrated that nuclear BRAFV600E is associated with melanoma aggressiveness and vemurafenib resistance. However, the underlying mechanisms of how nuclear localization of BRAFV600E promotes cell aggressiveness have not yet been investigated. Despite therapeutic advancements targeting cutaneous melanoma, unknown cellular processes prevent effective treatment for this malignancy, prompting an urgent need to identify new biological targets. This study aims to explore the association of inducible heme oxygenase 1 (HMOX-1) with nuclear BRAFV600E in promoting melanoma aggressiveness. Methods: Proteomics analysis was performed to identify the interacting partner(s) of nuclear BRAFV600E. Immunohistochemistry was applied to evaluate the levels of HMOX-1 and nuclear BRAFV600E expression in melanoma and adjacent healthy tissues. Immunofluorescence assessed the nuclear localization of BRAFV600E in vemurafenib-resistant A375R melanoma cells. Further study of HMOX-1 knockdown or BRAFV600E overexpression in melanoma cells suggested a role for HMOX-1 in the regulation of cell proliferation in vivo and in vitro. Finally, Western blot analysis was performed to confirm the pathway by which HMOX-1 mediates Akt signaling. Results: Proteomics results showed that HMOX-1 protein expression was 10-fold higher in resistant A375R cells compared to parental counterpart cells. In vitro and in vivo results illustrate that nuclear BRAFV600E promotes HMOX-1 overexpression, whereas HMOX-1 reduction represses melanoma cell proliferation and tumor growth. Mechanistic studies revealed that HMOX-1 was associated with nuclear BRAFV600E localization, thus promoting melanoma proliferation via a persistent activation of the AKT pathway. Conclusions: Our results highlight a previously unknown mechanism in which the nuclear BRAFV600E/HMOX-1/AKT axis plays an essential role in melanoma cell proliferation. Targeting HMOX-1 could be a novel method for treating melanoma patients who develop BRAF inhibitor resistance.

Effect of Arsenic Trioxide on Uveal Melanoma Cell Proliferation in vitro

2007 ◽  
Vol 39 (6) ◽  
pp. 302-307 ◽  
Author(s):  
Chunfang Wang ◽  
Bin Li ◽  
Haiyan Zhang ◽  
Guangpu Shi ◽  
Weihong Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Arsenic Trioxide ◽  
Uveal Melanoma ◽  
Melanoma Cell ◽  
Uveal Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation In Vitro

scholarly journals Melanoma treatment via non-specific adhesion of cancer cells using charged nano-clays in pre-clinical studies

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sahel N. Abduljauwad ◽  
Habib-ur-Rehman Ahmed ◽  
Vincent T. Moy
Keyword(s):  
Cell Proliferation ◽  
Side Effects ◽  
Cell Viability ◽  
Cancer Cells ◽  
Melanoma Cell ◽  
Tumour Size ◽  
Nano Clay ◽  
Melanoma Cell Proliferation

AbstractThe incidence of malignant melanoma has rapidly increased in the last two decades. There are many challenges associated with the current conventional therapies, including tumour size and location, the specificity of treatments, tumour resistance, non-mutually exclusive mutations, drug resistance, and many adverse side effects. Due to conventional therapies having several limitations, we have explored an alternative therapy such as nano-clays; nano-sized natural materials originating from clay fraction of the soil. Recently, clay nanoparticles have increasingly been used as a drug carrier for cancer treatment due to their high absorption, ability to engulf microbes, and low toxicity. In this study, we evaluated the effects of a nano-clays mix on melanoma cell proliferation and cell viability in vitro and melanoma growth in vivo xenograft animal model. The in vitro study revealed that nano-clay treatments significantly reduced melanoma cell proliferation and cell viability in a dosage-dependent manner. The in vivo tumour xenograft model demonstrated that nano-clay mix treatment led to significantly reduced tumour size and weight, decreased tumour cell mitosis, and induced tumour necrosis. These processes owe to the most probable changes in the membrane potential of the cancer cells once nano-clays bind with the former through the high non-specific adhesion characteristic of the cancer cells. As the data suggest an important role of nano-clays as an inhibitor of melanoma cell proliferation and survival, these prove to be a natural and effective medicine for the treatment of melanoma. The proven compatibility of nano-clays with the human cells with little side-effects makes them a highly preferred choice for the treatment of melanoma and probably other types of cancers.

Effects of retinoic acid steroidal analogs on human leukemic HL60 cell proliferation in vitro and on angiogenesis in vivo

2005 ◽  
Vol 16 (2) ◽  
pp. 151-158 ◽  
Author(s):  
Evaggelia S. Arsenou ◽  
Evangelia P. Papadimitriou ◽  
Eleni Kliafa ◽  
Maria Hountala ◽  
Sotiris S. Nikolaropoulos
Keyword(s):  
Cell Proliferation ◽  
Retinoic Acid ◽  
Hl60 Cell ◽  
Proliferation In Vitro

scholarly journals Anti-angiogenic compound (TNP-470) inhibits mesangial cell proliferation in vitro and in vivo

1997 ◽  
Vol 51 (6) ◽  
pp. 1838-1846 ◽  
Author(s):  
Masashi Haraguchi ◽  
Mikio Okamura ◽  
Masayo Konishi ◽  
Yoshio Konishi ◽  
Nobuo Negoro ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Mesangial Cell Proliferation ◽  
Proliferation In Vitro

scholarly journals The effect of a novel frizzled 8-related antiproliferative factor on in vitro carcinoma and melanoma cell proliferation and invasion

2011 ◽  
Vol 30 (5) ◽  
pp. 1849-1864 ◽  
Author(s):  
Kristopher R. Koch ◽  
Chen-Ou Zhang ◽  
Piotr Kaczmarek ◽  
Joseph Barchi ◽  
Li Guo ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Melanoma Cell ◽  
Melanoma Cell Proliferation ◽  
Proliferation And Invasion
Sign in / Sign up

Export Citation Format

Share Document