Molecular mechanism of miR-34b-5p and RNA binding protein HuR binding to lncRNA OIP5-AS1 in colon cancer cells

2021 ◽  
Author(s):  
Yan Wang ◽  
Changkun Lin ◽  
Yang Liu
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Molecular Mechanism ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Colon Cancer Cells

CBX8 acts as an independent RNA-binding protein to regulate the maturation of miR-378a-3p in colon cancer cells

Human Cell ◽  
2021 ◽  
Author(s):  
Xin Song ◽  
Wu Ning ◽  
Jinwei Niu ◽  
Guochao Zhang ◽  
Haibin Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Colon Cancer Cells

scholarly journals RNA Binding Protein RBM3 Modulates Novel LncRNAs to Increase Tumor Progression in Colon Cancer Cells

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Afreen Sayed ◽  
Sonali Choudhury ◽  
Dharmalingam Subramaniam ◽  
Sumedha Gunewardena ◽  
Sivapriya Ponnurangam ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Colon Cancer Cells

Radiation Induces Autophagic Cell Death of Colon Cancer Cells in Part Through Increasing RNA Binding Protein CUGBP2 Expression

2011 ◽  
Vol 140 (5) ◽  
pp. S-828
Author(s):  
Satish Ramalingam ◽  
Dharmalingam Subramaniam ◽  
Zhiyun He ◽  
Courtney W. Houchen ◽  
Shrikant Anant
Keyword(s):  
Colon Cancer ◽  
Cell Death ◽  
Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Autophagic Cell Death ◽  
Colon Cancer Cells

Su1772 - The RNA Binding Protein Imp1 Enhances Colon Cancer Metastasis via Promotion of a Pro-Metastatic Gene Expression Program

2018 ◽  
Vol 154 (6) ◽  
pp. S-585
Author(s):  
Sarah F. Andres ◽  
Kathy N. Williams ◽  
Kathryn E. Hamilton ◽  
Rei Mizuno ◽  
Jeff Headd ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Metastasis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Gene Expression Program ◽  
Colon Cancer Metastasis ◽  
Expression Program

Abstract 3198: The RNA-binding protein Musashi-1 stabilizes TAC1 mRNA in breast cancer cells.

2013 ◽  
Author(s):  
George R. Nahas ◽  
Raghav G. Murthy ◽  
Steven J. Greco ◽  
Pranela Rameshwar
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

854 – Rna Binding Protein Imp1 Promotes Exosome Production in Colon Cancer

2019 ◽  
Vol 156 (6) ◽  
pp. S-188
Author(s):  
Sarah F. Andres ◽  
Ranjan Preet ◽  
Sukanya Das ◽  
Jiegang Yang ◽  
Priya Chatterji ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a

2019 ◽  
Vol 114 ◽  
pp. 108772 ◽  
Author(s):  
Lansheng Zhang ◽  
Yanwei Chen ◽  
Caihong Li ◽  
Jinyang Liu ◽  
Huiwen Ren ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Neuropilin 1

scholarly journals PADI3 plays an antitumor role via the Hsp90/CKS1 pathway in colon cancer

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhengbin Chai ◽  
Li Wang ◽  
Yabing Zheng ◽  
Na Liang ◽  
Xiwei Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Molecular Mechanism ◽  
Expression Pattern ◽  
Colony Formation ◽  
Regulatory Mechanism ◽  
Cancer Cell Proliferation ◽  
Colon Cancer Cells ◽  
Cancer Tissues

Abstract Background CKS1 is highly expressed in colon cancer tissues, and is essential for cancer cell proliferation. The downstream molecular mechanism of CKS1 has been fully studied, but the upstream regulatory mechanism of it is still unclear. Earlier research found that PADI3 plays its anti-tumor roles via suppress cell proliferation, in this study, we found that the expression pattern of PADI3 and CKS1 are negatively correlated in colon cancer tissues, and overexpression of PADI3 can partly reverse CKS1 induced cancer cell proliferation. However, the regulatory mechanism of PADI3 and CKS1 in the tumorigenesis of colon cancer is still unclear and need to do further research. Methods Western blot and real-time PCR were used to detect the expression levels of genes. CCK-8 and colony formation assays were used to examine cell proliferation and colony formation ability. Overexpression and rescue experiments were used to study the molecular mechanism of CKS1 in colon cancer cells, BALB/c nude mice were used to study the function of CKS1 in vivo. Results CKS1 is highly expressed in colon cancer tissues, and the overexpression of CKS1 promotes cell proliferation and colony formation in both HCT116 (originating from primary colon cancer) and SW620 (originating from metastatic tumor nodules of colon cancer) cells. CKS1-expressing HCT116 cells produced larger tumors than the control cells. The expression pattern of PADI3 and CKS1 are negatively correlation in clinical samples of colon cancer, further study indicates that PADI3 can significantly decrease Hsp90 and CKS1 expression, and Hsp90 is essential for PADI3 to downregulate CKS1expression in colon cancer cells. Conclusions PADI3 exerts its antitumor activity by inhibiting Hsp90 and CKS1 expression, and Hsp90 is essential for PADI3 to suppress CKS1 expression.

scholarly journals The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

2012 ◽  
Vol 8 (4) ◽  
pp. 290-297 ◽  
Author(s):  
Michelina Plateroti ◽  
Patricia Rosa de Araujo ◽  
Acarizia Eduardo da Silva ◽  
Luiz O. F. Penalva
Keyword(s):  
Colon Cancer ◽  
Intestinal Epithelium ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cancer Development ◽  
Major Player

scholarly journals PTB-Associated Splicing Factor (PSF) Is a PPARγ-Binding Protein and Growth Regulator of Colon Cancer Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58749 ◽  
Author(s):  
Tamotsu Tsukahara ◽  
Hisao Haniu ◽  
Yoshikazu Matsuda
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Growth Regulator ◽  
Binding Protein ◽  
Splicing Factor ◽  
Colon Cancer Cells
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