854 – Rna Binding Protein Imp1 Promotes Exosome Production in Colon Cancer

2019 ◽  
Vol 156 (6) ◽  
pp. S-188
Author(s):  
Sarah F. Andres ◽  
Ranjan Preet ◽  
Sukanya Das ◽  
Jiegang Yang ◽  
Priya Chatterji ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals The RNA-Binding Protein Musashi1: A Major Player in Intestinal Epithelium Renewal and Colon Cancer Development

2012 ◽  
Vol 8 (4) ◽  
pp. 290-297 ◽  
Author(s):  
Michelina Plateroti ◽  
Patricia Rosa de Araujo ◽  
Acarizia Eduardo da Silva ◽  
Luiz O. F. Penalva
Keyword(s):  
Colon Cancer ◽  
Intestinal Epithelium ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Cancer Development ◽  
Major Player

Su1169 RNA BINDING PROTEIN IMP1 MODULATES EXOSOME BIOLOGY IN COLON CANCER

2020 ◽  
Vol 158 (6) ◽  
pp. S-531
Author(s):  
Sarah F. Andres ◽  
Ranjan Preet ◽  
Wei Zhang ◽  
Jiegang Yang ◽  
Sukanya Das ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1

2015 ◽  
Vol 9 (7) ◽  
pp. 1406-1420 ◽  
Author(s):  
Lan Lan ◽  
Carl Appelman ◽  
Amber R. Smith ◽  
Jia Yu ◽  
Sarah Larsen ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Natural Product ◽  
Cancer Cell ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Colon Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Expression of oncofetal RNA-binding protein CRD-BP/IMP1 predicts clinical outcome in colon cancer

2007 ◽  
Vol 121 (3) ◽  
pp. 486-494 ◽  
Author(s):  
Euthymios Dimitriadis ◽  
Theoni Trangas ◽  
Stavros Milatos ◽  
Periklis G. Foukas ◽  
Ioannis Gioulbasanis ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Clinical Outcome ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein

scholarly journals Development and Validation of a Novel Five-Gene-Based RNA Binding Protein Associated Prognostic Model for Human Colon Cancer

2020 ◽  
Author(s):  
Haoling Liu ◽  
Qingquan Bai ◽  
Zhaoyang Lu ◽  
Xuan Song ◽  
Yao Liu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Model ◽  
Rna Binding ◽  
Malignant Tumors ◽  
Binding Protein ◽  
Characteristic Curve ◽  
Rna Binding Protein ◽  
The Cancer Genome Atlas ◽  
Human Colon Cancer ◽  
Good Ability

Abstract Background: Dysregulation of RNA binding protein (RBP) expression has been reported in various malignant tumors, and it is related to the occurrence and development of cancer. However, the role of RBPs in colon cancer remains unclear. Methods: We downloaded the RNA sequencing data of colon cancer from The Cancer Genome Atlas (TCGA) database, and determined the differently expressed RBPs between normal and cancer tissues. Then, through a series of bioinformatics analysis, we systematically studied the expression and prognostic value of these RBPs.Result: A total of 490 different expression differently expressed RBPs were identified, including 323 up-regulated and 167 down regulated RBPs. Five RBPs (PNLDC1, NSUN6, NOL3, PPARGC1A, LRRFIP2) were identified as prognosis related genes for the construction of prognostic model. Further analysis showed that the overall survival rate (OS) of patients in the high-risk subgroup was worse than that in the low-risk subgroup based on this model. The area under the characteristic curve of time-dependent receiver was 0.691 in TCGA and 0.624 in GEO, which confirmed the prognostic model to be a good one. We also established a nominal map based on the internal validation in 5 RBPs mRNAs and TCGA sequeues, showing a good ability to differentiate colon cancer.Conclusions: We screened RBPs expression differences between colon cancer and adjacent non tumor colon tissues using the TCGA database to identify potential gene biomarkers.Besides,a very effective prediction model was constructed and tested based on the differential expression of RBPs using the TCGA and Gene Expression Omnibus (GEO) database.We also Validated of the relationship between the expression of five RBPs and prognosis

scholarly journals RNA Binding Protein RBM3 Modulates Novel LncRNAs to Increase Tumor Progression in Colon Cancer Cells

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Afreen Sayed ◽  
Sonali Choudhury ◽  
Dharmalingam Subramaniam ◽  
Sumedha Gunewardena ◽  
Sivapriya Ponnurangam ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Colon Cancer Cells
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