scholarly journals A transferable machine-learning framework linking interstice distribution and plastic heterogeneity in metallic glasses

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Qi Wang ◽  
Anubhav Jain
Keyword(s):  
Machine Learning ◽  
Metallic Glasses ◽  
Predictive Power ◽  
Structural Information ◽  
Shear Bands ◽  
Specific Property ◽  
Plastic Response ◽  
Learning Framework ◽  
Probability Estimates ◽  
General Data

AbstractWhen metallic glasses (MGs) are subjected to mechanical loads, the plastic response of atoms is non-uniform. However, the extent and manner in which atomic environment signatures present in the undeformed structure determine this plastic heterogeneity remain elusive. Here, we demonstrate that novel site environment features that characterize interstice distributions around atoms combined with machine learning (ML) can reliably identify plastic sites in several Cu-Zr compositions. Using only quenched structural information as input, the ML-based plastic probability estimates (“quench-in softness” metric) can identify plastic sites that could activate at high strains, losing predictive power only upon the formation of shear bands. Moreover, we reveal that a quench-in softness model trained on a single composition and quench rate substantially improves upon previous models in generalizing to different compositions and completely different MG systems (Ni62Nb38, Al90Sm10 and Fe80P20). Our work presents a general, data-centric framework that could potentially be used to address the structural origin of any site-specific property in MGs.

scholarly journals Machine learning based classification of cells into chronological stages using single-cell transcriptomics

2018 ◽  
Author(s):  
Sumeet Pal Singh ◽  
Sharan Janjuha ◽  
Samata Chaudhuri ◽  
Susanne Reinhardt ◽  
Sevina Dietz ◽  
...  
Keyword(s):  
Machine Learning ◽  
Single Cell ◽  
Predictive Power ◽  
Single Cells ◽  
Premature Aging ◽  
Calorie Intake ◽  
Learning Framework ◽  
Pancreatic Cells ◽  
Age Related ◽  
The Impact

ABSTRACTAge-associated deterioration of cellular physiology leads to pathological conditions. The ability to detect premature aging could provide a window for preventive therapies against age-related diseases. However, the techniques for determining cellular age are limited, as they rely on a limited set of histological markers and lack predictive power. Here, we implement GERAS (GEnetic Reference for Age of Single-cell), a machine learning based framework capable of assigning individual cells to chronological stages based on their trans criptomes. GERAS displays greater than 90% accuracy in classifying the chronological stage of zebrafish and human pancreatic cells. The framework demonstrates robustness against biological and technical noise, as evaluated by its performance on independent samplings of single-cells. Additionally, GERAS determines the impact of differences in calorie intake and BMI on the aging of zebrafish and human pancreatic cells, respectively. We further harness the predictive power of GERAS to identify genome-wide molecular factors that correlate with aging. We show that one of these factors, junb, is necessary to maintain the proliferative state of juvenile beta-cells. Our results showcase the applicability of a machine learning framework to classify the chronological stage of heterogeneous cell populations, while enabling to detect pro-aging factors and candidate genes associated with aging.

scholarly journals A Fuzzy Least Squares Support Tensor Machines in Machine Learning

2015 ◽  
Vol 10 (8) ◽  
pp. 4 ◽  
Author(s):  
Ruiting Zhang ◽  
Zhijian Zhou
Keyword(s):  
Machine Learning ◽  
Least Squares ◽  
Structural Information ◽  
Linear Equations ◽  
Computation Time ◽  
High Dimensional ◽  
Traditional Learning ◽  
Object A ◽  
Learning Framework ◽  
Decision Variables

In the machine learning field, high-dimensional data are often encountered in the real applications. Most of the traditional learning algorithms are based on the vector space model, such as SVM. Tensor representation is useful to the over fitting problem in vector-based learning, and tensor-based algorithm requires a smaller set of decision variables as compared to vector-based approaches. We also would require that the meaningful training points must be classified correctly and would not care about some training points like noises whether or not they are classified correctly. To utilize the structural information present in high dimensional features of an object, a tensor-based learning framework, termed as Fuzzy Least Squares support tensor machine (FLSSTM), where the classifier is obtained by solving a system of linear equations rather than a quadratic programming problem at each iteration of FLSSTM algorithm as compared to STM algorithm. This in turn provides a significant reduction in the computation time, as well as comparable classification accuracy. The efficacy of the proposed method has been demonstrated in ORL database and Yale database. The FLSSTM outperforms other tensor-based algorithms, for example, LSSTM, especially when training size is small.

scholarly journals Prediction and Analysis of the Severity and Number of Suburban Accidents Using Logit Model, Factor Analysis and Machine Learning: A case study in a developing country

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Meisam Ghasedi ◽  
Maryam Sarfjoo ◽  
Iraj Bargegol
Keyword(s):  
Machine Learning ◽  
Factor Analysis ◽  
Logit Model ◽  
Predictive Power ◽  
Dominant Role ◽  
Learning Approaches ◽  
Lighting Condition ◽  
Rainy Weather ◽  
Pedestrian Accidents ◽  
Effective Principal

AbstractThe purpose of this study is to investigate and determine the factors affecting vehicle and pedestrian accidents taking place in the busiest suburban highway of Guilan Province located in the north of Iran and provide the most accurate prediction model. Therefore, the effective principal variables and the probability of occurrence of each category of crashes are analyzed and computed utilizing the factor analysis, logit, and Machine Learning approaches simultaneously. This method not only could contribute to achieving the most comprehensive and efficient model to specify the major contributing factor, but also it can provide officials with suggestions to take effective measures with higher precision to lessen accident impacts and improve road safety. Both the factor analysis and logit model show the significant roles of exceeding lawful speed, rainy weather and driver age (30–50) variables in the severity of vehicle accidents. On the other hand, the rainy weather and lighting condition variables as the most contributing factors in pedestrian accidents severity, underline the dominant role of environmental factors in the severity of all vehicle-pedestrian accidents. Moreover, considering both utilized methods, the machine-learning model has higher predictive power in all cases, especially in pedestrian accidents, with 41.6% increase in the predictive power of fatal accidents and 12.4% in whole accidents. Thus, the Artificial Neural Network model is chosen as the superior approach in predicting the number and severity of crashes. Besides, the good performance and validation of the machine learning is proved through performance and sensitivity analysis.

scholarly journals SCOUR: a stepwise machine learning framework for predicting metabolite-dependent regulatory interactions

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Justin Y. Lee ◽  
Britney Nguyen ◽  
Carlos Orosco ◽  
Mark P. Styczynski
Keyword(s):  
Machine Learning ◽  
Metabolic Networks ◽  
Sampling Frequency ◽  
Low Noise ◽  
Training Data ◽  
High Noise ◽  
Regulatory Interactions ◽  
Learning Framework ◽  
Metabolic Systems ◽  
Noise Data

Abstract Background The topology of metabolic networks is both well-studied and remarkably well-conserved across many species. The regulation of these networks, however, is much more poorly characterized, though it is known to be divergent across organisms—two characteristics that make it difficult to model metabolic networks accurately. While many computational methods have been built to unravel transcriptional regulation, there have been few approaches developed for systems-scale analysis and study of metabolic regulation. Here, we present a stepwise machine learning framework that applies established algorithms to identify regulatory interactions in metabolic systems based on metabolic data: stepwise classification of unknown regulation, or SCOUR. Results We evaluated our framework on both noiseless and noisy data, using several models of varying sizes and topologies to show that our approach is generalizable. We found that, when testing on data under the most realistic conditions (low sampling frequency and high noise), SCOUR could identify reaction fluxes controlled only by the concentration of a single metabolite (its primary substrate) with high accuracy. The positive predictive value (PPV) for identifying reactions controlled by the concentration of two metabolites ranged from 32 to 88% for noiseless data, 9.2 to 49% for either low sampling frequency/low noise or high sampling frequency/high noise data, and 6.6–27% for low sampling frequency/high noise data, with results typically sufficiently high for lab validation to be a practical endeavor. While the PPVs for reactions controlled by three metabolites were lower, they were still in most cases significantly better than random classification. Conclusions SCOUR uses a novel approach to synthetically generate the training data needed to identify regulators of reaction fluxes in a given metabolic system, enabling metabolomics and fluxomics data to be leveraged for regulatory structure inference. By identifying and triaging the most likely candidate regulatory interactions, SCOUR can drastically reduce the amount of time needed to identify and experimentally validate metabolic regulatory interactions. As high-throughput experimental methods for testing these interactions are further developed, SCOUR will provide critical impact in the development of predictive metabolic models in new organisms and pathways.

Simulation of sports movement training based on machine learning and brain-computer interface

2020 ◽  
pp. 1-12
Author(s):  
Linuo Wang
Keyword(s):  
Machine Learning ◽  
Time Series ◽  
Joint Learning ◽  
Scientific Methods ◽  
Learning Framework ◽  
Brain Functions ◽  
Movement Training ◽  
Practical Effect ◽  
Machine Interface ◽  
The Brain

Injuries and hidden dangers in training have a greater impact on athletes ’careers. In particular, the brain function that controls the motor function area has a greater impact on the athlete ’s competitive ability. Based on this, it is necessary to adopt scientific methods to recognize brain functions. In this paper, we study the structure of motor brain-computer and improve it based on traditional methods. Moreover, supported by machine learning and SVM technology, this study uses a DSP filter to convert the preprocessed EEG signal X into a time series, and adjusts the distance between the time series to classify the data. In order to solve the inconsistency of DSP algorithms, a multi-layer joint learning framework based on logistic regression model is proposed, and a brain-machine interface system of sports based on machine learning and SVM is constructed. In addition, this study designed a control experiment to improve the performance of the method proposed by this study. The research results show that the method in this paper has a certain practical effect and can be applied to sports.

scholarly journals Physiological sleep measures predict time to 15‐year mortality in community adults: Application of a novel machine learning framework

2021 ◽  
Author(s):  
Meredith L. Wallace ◽  
Timothy S. Coleman ◽  
Lucas K. Mentch ◽  
Daniel J. Buysse ◽  
Jessica L. Graves ◽  
...  
Keyword(s):  
Machine Learning ◽  
Learning Framework ◽  
Physiological Sleep
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