scholarly journals The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Pablo Tristán-Ramos ◽  
Alejandro Rubio-Roldan ◽  
Guillermo Peris ◽  
Laura Sánchez ◽  
Suyapa Amador-Cubero ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Lung ◽  
Structure And Function ◽  
Human Lung Cancer ◽  
Genome Integrity ◽  
Class 1 ◽  
Somatic Genome ◽  
Human Line ◽  
And Function ◽  
Long Interspersed Element

Abstract Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect tumor malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate oncogene expression and are frequently downregulated in cancer. Here we explore whether they also influence L1 mobilization. We show that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein, ORF2p, reducing its mobilization. Overall, our data reveals that let-7, one of the most relevant microRNAs, maintains somatic genome integrity by restricting L1 retrotransposition.

scholarly journals The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition

2020 ◽  
Author(s):  
Pablo Tristán-Ramos ◽  
Alejandro Rubio-Roldan ◽  
Guillermo Peris ◽  
Laura Sánchez ◽  
Suyapa Amador-Cubero ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Human Lung ◽  
Structure And Function ◽  
Human Lung Cancer ◽  
Genome Integrity ◽  
Class 1 ◽  
Somatic Genome ◽  
Human Line ◽  
And Function ◽  
Long Interspersed Element

ABSTRACTNearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate oncogene expression and are frequently downregulated in cancer. Here we explore whether they also influence L1 mobilization. We found that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein, ORF2p, reducing its mobilization. Overall, our data uncover a new role for let-7, one of the most relevant microRNAs, which is to maintain somatic genome integrity by restricting L1 retrotransposition.

scholarly journals Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer

Oncogene ◽  
2003 ◽  
Vol 22 (12) ◽  
pp. 1892-1905 ◽  
Author(s):  
Hiroyuki Konishi ◽  
Miyabi Sugiyama ◽  
Kotaro Mizuno ◽  
Hiroko Saito ◽  
Yasushi Yatabe ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Detailed Characterization ◽  
Candidate Tumor Suppressor

scholarly journals Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

Oncogene ◽  
2005 ◽  
Vol 24 (35) ◽  
pp. 5502-5509 ◽  
Author(s):  
Monica Spinola ◽  
Antonella Galvan ◽  
Carmen Pignatiello ◽  
Barbara Conti ◽  
Ugo Pastorino ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Lung ◽  
Functional Characterization ◽  
Suppressor Gene ◽  
Human Lung Cancer ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

The aging lung

1999 ◽  
Vol 9 (2) ◽  
pp. 103-115 ◽  
Author(s):  
Christopher AE Dyer ◽  
Robert A Stockley
Keyword(s):  
Lung Disease ◽  
Elderly People ◽  
Human Lung ◽  
Environmental Pollutants ◽  
Tobacco Consumption ◽  
Structure And Function ◽  
Lung Structure ◽  
Pulmonary Changes ◽  
And Function ◽  
Disease Exposure

Over a lifetime, the human lung is exposed to a multitude of factors capable of altering its structure and function. The frequency of acute, self-limiting lung disease, exposure to environmental pollutants and previous tobacco consumption in elderly people makes it difficult to identify pulmonary changes that can be attributed to ‘normal aging’ alone. It is likely that all these factors may have some influence on both lung structure and function.

scholarly journals Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells

Oncogene ◽  
2005 ◽  
Vol 24 (56) ◽  
pp. 8229-8239 ◽  
Author(s):  
Xiaolin Bi ◽  
Tamara Jones ◽  
Fatima Abbasi ◽  
Heuijung Lee ◽  
Brian Stultz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Nuclear Export ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals A catalog of genes homozygously deleted in human lung cancer and the candidacy ofPTPRDas a tumor suppressor gene

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Takashi Kohno ◽  
Ayaka Otsuka ◽  
Luc Girard ◽  
Masanori Sato ◽  
Reika Iwakawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Lung ◽  
Suppressor Gene ◽  
Human Lung Cancer
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