scholarly journals Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mai Takakura ◽  
Reiko Nakagawa ◽  
Takeshi Ota ◽  
Yoko Kimura ◽  
Man Yung NG ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Memory Consolidation ◽  
Time Window ◽  
Initial Activity ◽  
Compositional Change ◽  
Consolidation Process ◽  
Memory State ◽  
Memory Updating ◽  
Gating Mechanism ◽  
Activity Dependent

AbstractConsolidated memory can be preserved or updated depending on the environmental change. Although such conflicting regulation may happen during memory updating, the flexibility of memory updating may have already been determined in the initial memory consolidation process. Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the compositional change in the transcriptional repressor, which contains the histone deacetylase Rpd3 and CoRest, acts as the gating mechanism that opens and closes the time window for activity-dependent transcription. Opening the gate through the compositional change in Rpd3/CoRest is required for memory consolidation, but closing the gate through Rpd3/CoRest is significant to limit future memory updating. Our data indicate that the flexibility of memory updating is determined through the initial activity-dependent transcription, providing a mechanism involved in defining memory state.

scholarly journals A novel non‐toxic histone deacetylase inhibitor enhances spatial memory consolidation in male mice

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Sarah B Beamish ◽  
Jawad B Belayet ◽  
Samer Alanani ◽  
Doug A Steeber ◽  
Mahmun M Hossain ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Histone Deacetylase ◽  
Memory Consolidation ◽  
Histone Deacetylase Inhibitor ◽  
Male Mice ◽  
Deacetylase Inhibitor

Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction

2016 ◽  
Vol 307 ◽  
pp. 46-53 ◽  
Author(s):  
Fernanda S. Petry ◽  
Arethuza S. Dornelles ◽  
Martina Lichtenfels ◽  
Fernanda E. Valiati ◽  
Caroline Brunetto de Farias ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Memory Consolidation ◽  
Receptor Antagonism ◽  
Histone Deacetylase Inhibition ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide

scholarly journals Skill reconsolidation does not operate at a rapid micro-timescale level

2022 ◽  
Author(s):  
Jasmine Herszage ◽  
Marlene Bönstrup ◽  
Leonardo G Cohen ◽  
Nitzan Censor
Keyword(s):  
Skill Acquisition ◽  
Memory Consolidation ◽  
Time Window ◽  
Sequence Data ◽  
Early Learning ◽  
Motor Sequence ◽  
Abundant Evidence ◽  
After Hours ◽  
Stages Of Learning ◽  
Memory Consolidation And Reconsolidation

Abundant evidence shows that consolidated memories are susceptible to modifications following their reactivation through reconsolidation. Processes of memory consolidation and reconsolidation have been commonly documented after hours or days. Motivated by studies showing rapid consolidation in early stages of skill acquisition, here we asked whether skill memories are susceptible to modifications through rapid reconsolidation, even at initial stages of learning. In a set of experiments, we collected crowdsourced online motor sequence data to test whether post-reactivation interference and enhancement occur through rapid reconsolidation. Results indicate that memories forming during early learning are not susceptible to interference nor to enhancement within a rapid reconsolidation time window, relative to control conditions. This set of evidence suggests that memory reconsolidation might be dependent on consolidation at the macro-timescale level, requiring hours or days to occur.

Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis

2005 ◽  
Vol 28 (1) ◽  
pp. 65-66
Author(s):  
Clive R. Bramham
Keyword(s):  
Memory Consolidation ◽  
Molecular Mechanisms ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Dendritic Protein Synthesis ◽  
Mechanisms Of Memory ◽  
Activity Dependent ◽  
Specific Contribution

Insights into the role of sleep in the molecular mechanisms of memory consolidation may come from studies of activity-dependent synaptic plasticity, such as long-term potentiation (LTP). This commentary posits a specific contribution of sleep to LTP stabilization, in which mRNA transported to dendrites during wakefulness is translated during sleep. Brain-derived neurotrophic factor may drive the translation of newly transported and resident mRNA.

Activity-Dependent Increase of the AHP Amplitude in T Sensory Neurons of the Leech

2002 ◽  
Vol 88 (5) ◽  
pp. 2490-2500 ◽  
Author(s):  
Rossana Scuri ◽  
Riccardo Mozzachiodi ◽  
Marcello Brunelli
Keyword(s):  
Sensory Neurons ◽  
Time Window ◽  
Training Session ◽  
Repetitive Stimulation ◽  
Short Term ◽  
Pharmacological Agents ◽  
Stimulus Interval ◽  
Short Term Plasticity ◽  
Intracellular Stimulation ◽  
Activity Dependent

We identified a new form of activity-dependent modulation of the afterhyperpolarization (AHP) in tactile (T) sensory neurons of the leech Hirudo medicinalis. Repetitive intracellular stimulation with 30 trains of depolarizing impulses at 15-s inter-stimulus interval (ISI) led to an increase of the AHP amplitude (∼60% of the control). The enhancement of AHP lasted for ≥15 min. The AHP increase was also elicited when a T neuron was activated by repetitive stimulation of its receptive field. The ISI was a critical parameter for the induction and maintenance of AHP enhancement. ISI duration had to fit within a time window with the upper limit of 20 s to make the training effective to induce an enhancement of the AHP amplitude. After recovery from potentiation, AHP amplitude could be enhanced once again by delivering another training session. The increase of AHP amplitude persisted in high Mg2+ saline, suggesting an intrinsic cellular mechanism for its induction. Previous investigations reported that AHP of leech T neurons was mainly due to the activity of the Na+/K+ ATPase and to a Ca2+-dependent K+ current ( I K/Ca). In addition, it has been demonstrated that serotonin (5HT) reduces AHP amplitude through the inhibition of the Na+/K+ATPase. By blocking the I K/Ca with pharmacological agents, such as cadmium and apamin, we still observed an increase of the AHP amplitude after repetitive stimulation, whereas 5HT application completely inhibited the AHP increment. These data indicate that the Na+/K+ATPase is involved in the induction and maintenance of the AHP increase after repetitive stimulation. Moreover, the AHP increase was affected by the level of serotonin in the CNS. Finally, the increase of the AHP amplitude produced a lasting depression of the synaptic connection between two T neurons, suggesting that this activity-dependent phenomenon might be involved in short-term plasticity associated with learning processes.

scholarly journals A Critical Time-Window for the Selective Induction of Hippocampal Memory Consolidation by a Brief Episode of Slow-Wave Sleep

2018 ◽  
Vol 34 (6) ◽  
pp. 1091-1099 ◽  
Author(s):  
Yi Lu ◽  
Zheng-Gang Zhu ◽  
Qing-Qing Ma ◽  
Yun-Ting Su ◽  
Yong Han ◽  
...  
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Time Window ◽  
Critical Time

scholarly journals Boosting Slow Oscillations during Sleep to Improve Memory Function in Elderly People: A Review of the Literature

2020 ◽  
Vol 10 (5) ◽  
pp. 300
Author(s):  
Federico Salfi ◽  
Aurora D’Atri ◽  
Daniela Tempesta ◽  
Luigi De Gennaro ◽  
Michele Ferrara
Keyword(s):  
Memory Consolidation ◽  
Time Window ◽  
Memory Function ◽  
The Elderly ◽  
Aging Brain ◽  
Slow Oscillations ◽  
Long Term Storage ◽  
Cognitive Benefits ◽  
Older Subjects

Sleep represents a crucial time window for the consolidation of memory traces. In this view, some brain rhythms play a pivotal role, first of all the sleep slow waves. In particular, the neocortical slow oscillations (SOs), in coordination with the hippocampal ripples and the thalamocortical spindles, support the long-term storage of the declarative memories. The aging brain is characterized by a disruption of this complex system with outcomes on the related cognitive functions. In recent years, the advancement of the comprehension of the sleep-dependent memory consolidation mechanisms has encouraged the development of techniques of SO enhancement during sleep to induce cognitive benefits. In this review, we focused on the studies reporting on the application of acoustic or electric stimulation procedures in order to improve sleep-dependent memory consolidation in older subjects. Although the current literature is limited and presents inconsistencies, there is promising evidence supporting the perspective to non-invasively manipulate the sleeping brain electrophysiology to improve cognition in the elderly, also shedding light on the mechanisms underlying the sleep-memory relations during healthy and pathological aging.

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