Different Phenomena Encountered during Dilatometry of Low-density Steels

In recent decades, highly alloyed low-density steels are being developed to reduce the weight of different automotive parts. Dilatometry can be a very useful experimental technique to understand phase transformations during heating or cooling of new low-density steel alloys. When performing dilatometry measurements some assumptions are made such as the homogeneity of the sample material tested during the experiment. In this study, dilatometry tests were performed for two different low-density steels, and the variations of the composition between the surface and the inner part of the sample were analyzed. The migration of manganese by diffusion from the interior of the samples and finally its evaporation on the surface under vacuum were observed. This compositional gradient generated in the samples may influence the veracity and interpretation of the results obtained in dilatometry when working with high manganese steel alloys. The detachment of surface grains created by this compositional change near the surface of the samples is also investigated.

Orally Administered Natural Lipid Nanoparticle-Loaded 6-Shogaol Shapes the Anti-Inflammatory Microbiota and Metabolome

The past decade has seen increasing interest in microbiota-targeting therapeutic strategies that aim to modulate the gut microbiota’s composition and/or function to treat chronic diseases, such as inflammatory bowel disease (IBD), metabolic symptoms, and obesity. While targeting the gut microbiota is an innovative means for treating IBD, it typically requires an extended treatment time, hampering its potential application. Herein, using an established natural-lipid nanoparticle (nLNP) platform, we demonstrate that nLNPs encapsulated with the drug candidate 6-shogaol (6S/nLNP) distinctly altered microbiota composition within one day of treatment, significantly accelerating a process that usually requires five days using free 6-shogaol (6S). In addition, the change in the composition of the microbiota induced by five-day treatment with 6S/nLNP was maintained for at least 15 days (from day five to day 20). The consequent alteration in the fecal metabolic profile stemming from this compositional change manifested as functional changes that enhanced the in vitro anti-inflammatory and wound-healing efficacy of macrophage cells (Raw 264.7) and epithelial cells (Caco-2 BBE1), respectively. Further, this metabolic compositional change, as reflected in an altered metabolic profile, promoted a robust anti-inflammatory effect in a DSS-induced mouse model of acute colitis. Our study demonstrates that, by near-instantly modulating microbiota composition and function, an nLNP-based drug-delivery platform might be a powerful tool for treating ulcerative colitis.

The Expansion of Higher Education and the Education-Health Gradient in the United States

The United States experienced a period of rapid higher education expansion between the mid-1940s and mid-1970s. Although this expansion likely improved the health of people able to take advantage of new education opportunities, expansion may have also intensified health inequalities between college-educated and non-college-educated people (1) through the compositional change in the relative (dis)advantage of these groups, (2) through the displacement of non-college-educated people in a more competitive post-expansion labor market, and (3) by increasing health returns to a college degree. Our analyses, rooted in a counterfactual perspective, draw on data from the Health and Retirement Study that spans birth cohorts who came of age before and after the period of expansion, allowing us to differentiate people who earned a degree because of expansion but would not otherwise (conditional-earners) from people who would or would not have earned a degree regardless of expansion (always-earners and never-earners, respectively). Comparing changes in the health of these three groups before and after education expansion permits us to individually evaluate how compositional change, displacement, and increasing returns to education exacerbated health inequalities. Our findings suggest that education expansion improved the health of conditional-earners and magnified health inequalities through the mechanism of displacement.

Aging of polypropylene probed by near infrared spectroscopy

This paper describes the first in-depth attempt to characterize thermally induced aging of polypropylene (PP) samples by near infrared (NIR) spectroscopy. Significant levels of variation in NIR bands associated with short (amorphous-dominated) and long (crystalline-dominated) helices was readily captured when PP samples were subjected to thermal aging treatment. Partial least squares (PLS) regression models derived from the NIR spectra indicated significant level of correlation between the actual and predicted elongations of the samples. Analysis of PLS scores and two-dimensional (2 D) correlation spectra derived from the aged PP samples revealed inner working mechanism of the regression model. Namely, the aging treatment essentially induces compositional change in crystalline and amorphous structures of the PP samples, which eventually affect the variation of the PLS scores. Thus, by utilizing the scores, it becomes possible to predict the change in the elongation property of the aged PP sample.

Interior of Jupiter in the context of Juno and Galileo: signature of a decoupling between the atmosphere and the interior

<p>Juno's observations of Jupiter's gravity field have revealed extremely low values for the gravitational moments that are difficult to reconcile with the high abundance of metals observed in the atmosphere by both Galileo and Juno. Recent studies chose to arbitrarily get rid of one of these two constraints in order to build models of Jupiter.</p><p>In this presentation, I will detail our new Jupiter structure models reconciling Juno and Galileo observational constraints. These models confirm the need to separate Jupiter into at least 4 layers: an outer convective shell, a non-convective zone of compositional change, an inner convective shell and a diluted core representing about 60 percent of the planet in radius. Compared to other studies, these models propose a new idea with important consequences: a decrease in the quantity of metals between the outer and inner convective shells. This would imply that the atmospheric composition is not representative of the internal composition of the planet, contrary to what is regularly admitted, and would strongly impact the Jupiter formation scenarios (localization, migration, accretion).</p><p>In particular, the presence of an internal non-convective zone prevents mixing between the two convective envelopes. I will detail the physical processes of this semi-convective zone (layered convection or H-He immiscibility) and explain how they may persist during the evolution of the planet.</p><p>These models also impose a limit mass on the compact core, which cannot be heavier than 5 Earth masses. Such a mass, lower than the runaway gas accretion minimum mass, needs to be explained in the light of our understanding of the formation and evolution of giant planets.</p><p>I will finally detail the application of our work to Saturn, and what we can expect to learn about the interior of the giant planets in the years to come. </p>

Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila

Consolidated memory can be preserved or updated depending on the environmental change. Although such conflicting regulation may happen during memory updating, the flexibility of memory updating may have already been determined in the initial memory consolidation process. Here, we explored the gating mechanism for activity-dependent transcription in memory consolidation, which is unexpectedly linked to the later memory updating in Drosophila. Through proteomic analysis, we discovered that the compositional change in the transcriptional repressor, which contains the histone deacetylase Rpd3 and CoRest, acts as the gating mechanism that opens and closes the time window for activity-dependent transcription. Opening the gate through the compositional change in Rpd3/CoRest is required for memory consolidation, but closing the gate through Rpd3/CoRest is significant to limit future memory updating. Our data indicate that the flexibility of memory updating is determined through the initial activity-dependent transcription, providing a mechanism involved in defining memory state.