scholarly journals HIV-1 and human genetic variation

Author(s):  
Paul J. McLaren ◽  
Jacques Fellay
2019 ◽  
Author(s):  
Christian W. Thorball ◽  
Alessandro Borghesi ◽  
Nadine Bachmann ◽  
Chantal von Siebenthal ◽  
Valentina Vongrad ◽  
...  

ABSTRACTIntroductionA major hurdle to HIV-1 eradication is the establishment of a latent viral reservoir early after primary infection. Several factors are known to influence the HIV-1 reservoir size and decay rate on suppressive antiretroviral treatment (ART), but little is known about the role of human genetic variation.MethodsWe measured the reservoir size at three time points over a median of 5.4 years, and searched for associations between human genetic variation and two phenotypic readouts: the reservoir size at the first time point and its decay rate over the study period. We assessed the contribution of common genetic variants using genome-wide genotyping data from 797 patients with European ancestry enrolled in the Swiss HIV Cohort Study and searched for a potential impact of rare variants and exonic copy number variants using exome sequencing data generated in a subset of 194 study participants.ResultsGenome- and exome-wide analyses did not reveal any significant association with the size of the HIV-1 reservoir or its decay rate on suppressive ART.ConclusionsOur results point to a limited influence of human genetics on the size of the HIV-1 reservoir and its long-term dynamics in successfully treated individuals.


2013 ◽  
Author(s):  
István Bartha ◽  
Jonathan M Carlson ◽  
Chanson J Brumme ◽  
Paul J McLaren ◽  
Zabrina L Brumme ◽  
...  

2008 ◽  
Vol 36 (3) ◽  
pp. 471-477 ◽  
Author(s):  
Jennifer A. Hamilton

In 2000, researchers from the Human Genome Project (HGP) proclaimed that the initial sequencing of the human genome definitively proved, among other things, that there was no genetic basis for race. The genetic fact that most humans were 99.9% the same at the level of their DNA was widely heralded and circulated in the English-speaking press, especially in the United States. This pronouncement seemed proof that long-term antiracist efforts to de-biologize race were legitimized by scientific findings. Yet, despite the seemingly widespread acceptance of the social construction of race, post-HGP genetic science has seen a substantial shift toward the use of race variables in genetic research and, according to a number of prominent scholars, is re-invoking the specter of earlier forms of racial science in some rather discomfiting ways. During the past seven years, the main thrust of human genetic research, especially in the realm of biomedicine, has shifted from a concern with the 99.9% of the shared genome — what is thought to make humans alike — towards an explicit focus on the 0.1% that constitutes human genetic variation. Here I briefly explore some of the potential implications of the conceptualization and practice of early 21st century genetic variation research, especially as it relates to questions of race.


PEDIATRICS ◽  
1977 ◽  
Vol 59 (3) ◽  
pp. 432-432
Author(s):  
R. C. Lewontin ◽  

Only about 7% of all human genetic diversity is between major races. It would appear then that the superficial characters of skin color, hair form, lip, nose, and eye shape that we use to distinguish human races are atypical and do not represent the mode of human genetic variation. The taxonomic division of the human species into races places a completely disproportionate emphasis on a very small fraction of total human genetic diversity.


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