scholarly journals Functional classification of long non-coding RNAs by k-mer content

2018 ◽  
Vol 50 (10) ◽  
pp. 1474-1482 ◽  
Author(s):  
Jessime M. Kirk ◽  
Susan O. Kim ◽  
Kaoru Inoue ◽  
Matthew J. Smola ◽  
David M. Lee ◽  
...  
2021 ◽  
Vol 8 ◽  
Author(s):  
Tiqun Yang ◽  
Tianxin Long ◽  
Tailai Du ◽  
Yili Chen ◽  
Yugang Dong ◽  
...  

Cardiac remodeling occurs after the heart is exposed to stress, which is manifested by pathological processes such as cardiomyocyte hypertrophy and apoptosis, dendritic cells activation and cytokine secretion, proliferation and activation of fibroblasts, and finally leads to heart failure. Circular RNAs (circRNAs) are recently recognized as a specific type of non-coding RNAs that are expressed in different species, in different stages of development, and in different pathological conditions. Growing evidences have implicated that circRNAs play important regulatory roles in the pathogenesis of a variety of cardiovascular diseases. In this review, we summarize the biological origin, characteristics, functional classification of circRNAs and their regulatory functions in cardiomyocytes, endothelial cells, fibroblasts, immune cells, and exosomes in the pathogenesis of cardiac remodeling.


2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Jingwen Fang ◽  
Qing Ma ◽  
Ci Chu ◽  
Beibei Huang ◽  
Lingjie Li ◽  
...  

AbstractWe develop PIRCh-seq, a method which enables a comprehensive survey of chromatin-associated RNAs in a histone modification-specific manner. We identify hundreds of chromatin-associated RNAs in several cell types with substantially less contamination by nascent transcripts. Non-coding RNAs are found enriched on chromatin and are classified into functional groups based on the patterns of their association with specific histone modifications. We find single-stranded RNA bases are more chromatin-associated, and we discover hundreds of allele-specific RNA-chromatin interactions. These results provide a unique resource to globally study the functions of chromatin-associated lncRNAs and elucidate the basic mechanisms of chromatin-RNA interactions.


Physiotherapy ◽  
2013 ◽  
Vol 21 (3) ◽  
Author(s):  
Natalia Uścinowicz ◽  
Wojciech Seidel ◽  
Paweł Zostawa ◽  
Sebastian Klich

AbstractThe recent Olympic Games in London incited much interest in the competition of disabled athletes. Various people connected with swimming, including coaches and athletes, have speculated about the fairness of competitions of disabled athletes. A constant problem are the subjective methods of classification in disabled sport. Originally, athletes with disabilities were classified according to medical diagnosis. Due to the injustice which still affects the competitors, functional classification was created shortly after. In the present review, the authors show the anomalies in the structure of the classification. The presented discovery led to the suggestion to introduce objective methods, thanks to which it would be no longer necessary to rely on the subjective assessment of the classifier. According to the authors, while using objective methods does not completely rule out the possibility of fraud by disabled athletes in the classification process, it would certainly reduce their incidence. Some of the objective methods useful for the classification of disabled athletes are: posturography, evaluation of the muscle parameters, electrogoniometric assessment, surface electromyography, and analysis of kinematic parameters. These methods have provide objective evaluation in the diagnostic sense but only if they are used in tandem. The authors demonstrate the undeniable benefits of using objective methods. Unfortunately, there are not only advantages of such solution, there also several drawbacks to be found. The conclusion of the article is the statement by the authors that it is right to use objective methods which allow to further the most important rule in sport: fair-play.


2020 ◽  
Vol 73 (3) ◽  
pp. 358-367
Author(s):  
Júlio Cezar Rebés Azambuja Filho ◽  
Paulo Cesar de Faccio Carvalho ◽  
Olivier Jean François Bonnet ◽  
Denis Bastianelli ◽  
Magali Jouven

2000 ◽  
Vol 302 (1) ◽  
pp. 189-203 ◽  
Author(s):  
John R Cort ◽  
Adelinda Yee ◽  
Aled M Edwards ◽  
Cheryl H Arrowsmith ◽  
Michael A Kennedy

Author(s):  
Jan Willem Gorter ◽  
Peter L Rosenbaum ◽  
Steven E Hanna ◽  
Robert J Palisano ◽  
Doreen J Bartlett ◽  
...  

2018 ◽  
Vol 33 (3) ◽  
pp. 3784-3794 ◽  
Author(s):  
Qian Shi ◽  
Fei Zhuang ◽  
Ji-Ting Liu ◽  
Na Li ◽  
Yuan-Xiu Chen ◽  
...  

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