Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature

Introduction: Apocrine Carcinoma (AC) of breast is a rare breast cancer comprising only 0.3-1.0% of all breast cancers. Microscopically, Invasive Duct Carcinoma of No Special Type (IDC-NST) and AC have similar architecture, but they differ in cell morphology. Immunohistochemistry for both the tumour types is also different. Aim: This study was undertaken to know the incidence of AC and analyse them with respect to different clinicopathological features and compare them with that of IDC-NST. Materials and Methods: This was an observational study conducted in Department of Pathology, Veer Surendra Sai Institute of Medical Science and Research, Burla from March 2010 to February 2019. Patients diagnosed as invasive breast carcinoma were taken as study group. Breast cancer in male patients and female patients taking neoadjuvant chemotherapy were excluded from study group. Clinical features, pathological features and immunohistochemical findings of IDC-NST and AC were studied and statistical data were analysed by SPSS version 23.0 for windows. Comparison of data was done by using Pearson’s Chi-square test. Results having p-value <0.05 were accepted as significant. Results: During the 10 years, 05 cases of AC and 560 cases of IDC-NST were found. Mean age of presentation of AC was 59.5 years and that of IDC-NST was 50.4 years. Most cases of AC and IDC-NST presented with breast lump of size >5 cm. Low grade (grade 1) carcinoma was seen in 20% of AC. Immunohistochemistry showed 3 (60%) cases of AC as triple negative, whereas 213 (38.2%) of IDC-NST were triple negative. All the cases of AC were Gross Cystic Disease Fluid Protein (GCDFP-15) and CK-7 positive. Conclusion: AC is a rare category of breast cancer. Although prognosis of AC and IDC are almost similar, correct diagnosis of AC is important as antiandrogenic therapy can be given to Androgen Receptor (AR) positive AC cases.

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Expression of Survivin in Basal-Like and Triple Negative Breast Carcinoma and Associations with Clinicopathological Parameters

IIUM Medical Journal Malaysia ◽

10.31436/imjm.v20i1.1776 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Madatang A. ◽

Mohd Nafi S.N. ◽

Jaafar H. ◽

Wan Abdul Rahman W.F.

Keyword(s):

Breast Carcinoma ◽

Triple Negative ◽

Molecular Subtype ◽

Survivin Expression ◽

Prognostic Indicator ◽

Invasive Breast Carcinoma ◽

Clinicopathological Parameters ◽

Tubule Formation ◽

Cross Sectional ◽

Triple Negative Breast Carcinoma

INTRODUCTION: Triple negative breast carcinoma (TNBC) molecular subtype and its variant; basal-like triple negative (BLTN) carcinoma is an established poor prognostic indicator. The aim of this study is to analyse the survivin expression in TNBC and BLTN, and relating the results with clinicopathological parameters. MATERIALS AND METHODS: We conducted a cross sectional study using 94 archived formalin-fixed paraffin embedded tissue blocks of invasive breast carcinoma, no special type (NST). Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth receptor 2 (HER2) were used as surrogate markers to classify the cases into molecular subtypes. Samples with triple negative phenotype (ER, PR and HER2 negative) were stained with CK 5/6 to identify the BLTN subtype. All the samples were also immunostained for survivin. RESULT: Out of 94 cases, 41.5% (39 cases) were TNBC. Among the TNBC cases, only 41.0% (16 cases) were BLTN subtype when they found to be positive for CK 5/6. Among 94 cases of invasive breast carcinoma, 28.7% (27 cases) were survivin positive with (53.8%) 21 cases were TNBC and (11%) 6 cases were non-TNBC (p< 0.001). Among 16 cases of BLTN subtype, only 8 cases were survivin positive (p = 0.752). Survivin expression was also statistically significant with tubule formation (p=0.029), nuclear pleomorphism (p=0.008), tumour grade (p=0.010), ER status (p< 0.001) and PR status (p=0.001). CONCLUSION: Survivin expression was statistically significant in invasive breast carcinoma. Even though the expression was significantly high in TNBC, it is not related to whether it is a basal-like or non-basal-like variant.

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Abstract P6-01-04: Ductal Carcinoma In-Situ Associated with Triple-Negative Invasive Breast Carcinoma Is Often Immunohistochemically Distinct from Invasive Component

10.1158/0008-5472.sabcs10-p6-01-04 ◽

2010 ◽

Cited By ~ 1

Author(s):

RA Simon ◽

TA Karim ◽

C Zhang ◽

MM Steinhoff ◽

CJ Sung ◽

...

Keyword(s):

Breast Carcinoma ◽

Ductal Carcinoma In Situ ◽

Carcinoma In Situ ◽

Triple Negative ◽

Ductal Carcinoma ◽

Invasive Breast Carcinoma ◽

Invasive Component

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QUANTITATIVE CHARACTERISTICS OF CD68+ AND CD163+ MACROPHAGES IN THE PRIMARY FOCUS AND IN METASTATIC LESIONS OF REGIONAL LYMPH NODES IN TRIPLE-NEGATIVE INVASIVE BREAST CARCINOMA

Bulletin of Problems Biology and Medicine ◽

10.29254/2077-4214-2018-4-2-147-313-319 ◽

2018 ◽

Vol 2 (4) ◽

pp. 313

Author(s):

A. Z. Aikian ◽

I. P. Kaidashev

Keyword(s):

Breast Carcinoma ◽

Lymph Nodes ◽

Triple Negative ◽

Invasive Breast Carcinoma ◽

Regional Lymph Nodes ◽

Metastatic Lesions ◽

Quantitative Characteristics ◽

Primary Focus

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Metaplastic Breast Carcinoma: A Rare Entity

Nepalese Journal of Cancer ◽

10.3126/njc.v3i1.25918 ◽

2019 ◽

Vol 3 (1) ◽

pp. 57-59

Author(s):

Roshani Shrestha ◽

Prakash Raj Neupane ◽

Bandana Satyal

Keyword(s):

Case Report ◽

Breast Carcinoma ◽

Triple Negative ◽

Invasive Breast Carcinoma ◽

Rare Entity ◽

Large Tumor ◽

Large Tumor Size ◽

Lymphnode Metastasis ◽

Rare Malignancy ◽

Metaplastic Breast Carcinoma

Metaplastic Breast Carcinoma is a rare malignancy among invasive breast carcinoma. The patients usually present with large tumor size, axillary lymphnode metastasis and triple negative. The management of Metaplastic Breast carcinoma largely parallels that of Invasive Breast Carcinoma. In this case report, we found a case of metaplastic breast carcinoma with axillary lymphnode metastasis which is very rare.

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Expression of CD74 in Invasive Breast Carcinoma: Its Relation to Nottingham Prognostic Index, Hormone Receptors, and HER2 Immunoprofile

Tumori Journal ◽

10.5301/tj.5000562 ◽

2016 ◽

Vol 103 (2) ◽

pp. 193-203

Author(s):

Eiman Adel Hasby ◽

Rana Adel Khalifa

Keyword(s):

Breast Carcinoma ◽

Hormone Receptors ◽

Triple Negative ◽

Prognostic Index ◽

Nottingham Prognostic Index ◽

Invasive Breast Carcinoma ◽

Breast Carcinomas ◽

Immunohistochemical Expression ◽

Pathologic Stage ◽

Tumor Stages

Purpose To study the immunohistochemical expression of CD74 in series of invasive breast carcinomas classified according to their estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) immunoprofile and explore its correlation to Nottingham Prognostic Index (NPI) and tumor pathologic stage to determine if it has a prognostic value. Methods A total of 160 cases of mammary carcinoma were classified broadly according to their ER, PR, and HER2 expression into luminal, HER2-positive, and triple-negative groups. The NPI was calculated and pathologic stage was recorded for each individual case and cases were classified into different prognostic groups. The CD74 expression was evaluated immunohistochemically and correlated to different prognostic variables. Results The CD74 immunohistochemical expression in invasive breast carcinoma was significantly higher in triple-negative tumors, higher tumor grades, presence of lymph nodal metastasis, higher tumor stages, and higher NPI scores. Conclusions The CD74 might be a useful prognostic indicator predicting poor outcome of patients with breast carcinoma. Its consistent expression in triple-negative breast carcinomas points to the need of further studies to test the possibility if it can be targeted in treatment of breast carcinoma, especially in such groups.

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