scholarly journals Proteomic profiling of whole-saliva reveals correlation between Burning Mouth Syndrome and the neurotrophin signaling pathway

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Guy Krief ◽  
Yaron Haviv ◽  
Omer Deutsch ◽  
Naama Keshet ◽  
Galit Almoznino ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Burning Mouth Syndrome ◽  
Proteomic Profiling ◽  
Whole Saliva ◽  
Burning Mouth ◽  
Neurotrophin Signaling

scholarly journals Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

2006 ◽  
Vol 2006 ◽  
pp. 1-4 ◽  
Author(s):  
Daria Simcic ◽  
Sonja Pezelj-Ribaric ◽  
Renata Gržic ◽  
Jelena Horvat ◽  
Gordana Brumini ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Interleukin 2 ◽  
Severity Of Illness ◽  
Burning Mouth Syndrome ◽  
Control Group ◽  
Whole Saliva ◽  
Burning Mouth ◽  
Age Range ◽  
Healthy Participants

The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55–65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55–65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean34.1±9.7versus7.3±3.0pg/mL;P<.001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean30.8±5.6versus5.2±2.8pg/mL;P<.001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.

scholarly journals Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 929
Author(s):  
Pia Lopez-Jornet ◽  
Candela Castillo Felipe ◽  
Luis Pardo-Marin ◽  
Jose J. Ceron ◽  
Eduardo Pons-Fuster ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Salivary Flow ◽  
Health Impact ◽  
Burning Mouth Syndrome ◽  
Salivary Biomarkers ◽  
Inflammatory Protein ◽  
Whole Saliva ◽  
Burning Mouth ◽  
Positive Correlations

Objective: To evaluate a panel of salivary analytes involving biomarkers of inflammation, stress, immune system and antioxidant status in patients with burning mouth syndrome (BMS) and to study their relationship with clinical variables. Materials and Methods: A total of 51 patients with BMS and 31 controls were consecutively enrolled in the study, with the recording of oral habits, the severity of pain using a visual analogue scale (VAS), the Hospital Anxiety and Depression (HAD) score and the Oral Health Impact Profile-14 (OHIP14) score. Resting whole saliva was collected with the drainage technique, followed by the measurement of 11 biomarkers. Results: The salivary flow was higher in patients with BMS. Among all the biomarkers studied, significantly higher levels of alpha-amylase, immunoglobulin A (IgA), and macrophage inflammatory protein-4 (MIP4) and lower levels of uric acid and ferric reducing activity of plasma (FRAP) were observed in the saliva of patients with BMS as compared to the controls (p < 0.05 in all cases). Positive correlations were found between pain, oral quality of life and anxiety scores and salivary biomarkers. Conclusions: BMS is associated with changes in salivary biomarkers of inflammation, oxidative stress and stress, being related to the degree of pain and anxiety.

scholarly journals Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 392
Author(s):  
Candela Castillo-Felipe ◽  
Lorena Franco-Martínez ◽  
Asta Tvarijonaviciute ◽  
Pia Lopez-Jornet ◽  
Elsa Lamy
Keyword(s):  
Sleep Disturbances ◽  
Relevant Information ◽  
Burning Mouth Syndrome ◽  
Diagnostic Tools ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Number Of Factors ◽  
Whole Saliva ◽  
Burning Mouth ◽  
As Stress

Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosis.

Saliva on the oral mucosa and whole saliva in women diagnosed with burning mouth syndrome

Oral Diseases ◽  
2018 ◽  
Vol 24 (8) ◽  
pp. 1468-1476 ◽  
Author(s):  
Shikha Acharya ◽  
Catharina Hägglin ◽  
Mats Jontell ◽  
Bengt Wenneberg ◽  
Jörgen Ekström ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Burning Mouth Syndrome ◽  
Whole Saliva ◽  
Burning Mouth

Burning Mouth Syndrome

2013 ◽  
Vol 56 (9) ◽  
pp. 550
Author(s):  
Jae Won Chang ◽  
Chul-Ho Kim
Keyword(s):  
Burning Mouth Syndrome ◽  
Burning Mouth

scholarly journals Burning mouth syndrome - quality of life

BDJ ◽  
2021 ◽  
Vol 230 (2) ◽  
pp. 92-92
Author(s):  
Reena Wadia
Keyword(s):  
Quality Of Life ◽  
Burning Mouth Syndrome ◽  
Burning Mouth

scholarly journals Identification of upregulated NF-κB inhibitor alpha and IRAK3 targeting lncRNA following intracranial aneurysm rupture-induced subarachnoid hemorrhage

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei Leng ◽  
Dan Fan ◽  
Zhong Ren ◽  
Qiaoying Li
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Intracranial Aneurysm ◽  
Signaling Pathway ◽  
Aneurysm Rupture ◽  
Cytokine Receptor ◽  
Gene Set Enrichment Analysis ◽  
Receptor Interaction ◽  
Regulatory Pathways ◽  
Ruptured Intracranial Aneurysm ◽  
Neurotrophin Signaling

Abstract Background This study was performed to identify genes and lncRNAs involved in the pathogenesis of subarachnoid hemorrhage (SAH) from ruptured intracranial aneurysm (RIA). Methods Microarray GSE36791 was downloaded from Gene Expression Omnibus (GEO) database followed by the identification of significantly different expressed RNAs (DERs, including lncRNA and mRNA) between patients with SAH and healthy individuals. Then, the functional analyses of DEmRNAs were conducted and weighted gene co-expression network analysis (WGCNA) was also performed to extract the modules associated with SAH. Following, the lncRNA-mRNA co-expression network was constructed and the gene set enrichment analysis (GSEA) was performed to screen key RNA biomarkers involved in the pathogenesis of SAH from RIA. We also verified the results in a bigger dataset GSE7337. Results Totally, 561 DERs, including 25 DElncRNAs and 536 DEmRNAs, were identified. Functional analysis revealed that the DEmRNAs were mainly associated with immune response-associated GO-BP terms and KEGG pathways. Moreover, there were 6 modules significantly positive-correlated with SAH. The lncRNA-mRNA co-expression network contained 2 lncRNAs (LINC00265 and LINC00937) and 169 mRNAs. The GSEA analysis showed that these two lncRNAs were associated with three pathways (cytokine-cytokine receptor interaction, neurotrophin signaling pathway, and apoptosis). Additionally, IRAK3 and NFKBIA involved in the neurotrophin signaling pathway and apoptosis while IL1R2, IL18RAP and IL18R1 was associated with cytokine-cytokine receptor interaction pathway. The expression levels of these genes have the same trend in GSE36791 and GSE7337. Conclusion LINC00265 and LINC00937 may be implicated with the pathogenesis of SAH from RIA. They were involved in three important regulatory pathways. 5 mRNAs played important roles in the three pathways.

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