Saliva on the oral mucosa and whole saliva in women diagnosed with burning mouth syndrome

Oral Diseases ◽  
2018 ◽  
Vol 24 (8) ◽  
pp. 1468-1476 ◽  
Author(s):  
Shikha Acharya ◽  
Catharina Hägglin ◽  
Mats Jontell ◽  
Bengt Wenneberg ◽  
Jörgen Ekström ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Burning Mouth Syndrome ◽  
Whole Saliva ◽  
Burning Mouth

scholarly journals Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome

2006 ◽  
Vol 2006 ◽  
pp. 1-4 ◽  
Author(s):  
Daria Simcic ◽  
Sonja Pezelj-Ribaric ◽  
Renata Gržic ◽  
Jelena Horvat ◽  
Gordana Brumini ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Interleukin 2 ◽  
Severity Of Illness ◽  
Burning Mouth Syndrome ◽  
Control Group ◽  
Whole Saliva ◽  
Burning Mouth ◽  
Age Range ◽  
Healthy Participants

The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55–65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55–65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean34.1±9.7versus7.3±3.0pg/mL;P<.001. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean30.8±5.6versus5.2±2.8pg/mL;P<.001. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.

scholarly journals Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 929
Author(s):  
Pia Lopez-Jornet ◽  
Candela Castillo Felipe ◽  
Luis Pardo-Marin ◽  
Jose J. Ceron ◽  
Eduardo Pons-Fuster ◽  
...  
Keyword(s):  
Immunoglobulin A ◽  
Salivary Flow ◽  
Health Impact ◽  
Burning Mouth Syndrome ◽  
Salivary Biomarkers ◽  
Inflammatory Protein ◽  
Whole Saliva ◽  
Burning Mouth ◽  
Positive Correlations

Objective: To evaluate a panel of salivary analytes involving biomarkers of inflammation, stress, immune system and antioxidant status in patients with burning mouth syndrome (BMS) and to study their relationship with clinical variables. Materials and Methods: A total of 51 patients with BMS and 31 controls were consecutively enrolled in the study, with the recording of oral habits, the severity of pain using a visual analogue scale (VAS), the Hospital Anxiety and Depression (HAD) score and the Oral Health Impact Profile-14 (OHIP14) score. Resting whole saliva was collected with the drainage technique, followed by the measurement of 11 biomarkers. Results: The salivary flow was higher in patients with BMS. Among all the biomarkers studied, significantly higher levels of alpha-amylase, immunoglobulin A (IgA), and macrophage inflammatory protein-4 (MIP4) and lower levels of uric acid and ferric reducing activity of plasma (FRAP) were observed in the saliva of patients with BMS as compared to the controls (p < 0.05 in all cases). Positive correlations were found between pain, oral quality of life and anxiety scores and salivary biomarkers. Conclusions: BMS is associated with changes in salivary biomarkers of inflammation, oxidative stress and stress, being related to the degree of pain and anxiety.

Burning mouth syndrome- An Oral Physicians Dilemma

2017 ◽  
Vol 6 (4) ◽  
Author(s):  
N. Kavitaa
Keyword(s):  
Oral Mucosa ◽  
Facial Pain ◽  
Clinical Signs ◽  
Burning Mouth Syndrome ◽  
Burning Sensation ◽  
Pain Disorder ◽  
Treatment Modalities ◽  
Clear Cut ◽  
Burning Mouth

Burning Mouth Syndrome (BMS) is a chronic oro-facial pain disorder that affects both genders, but predominately with higher female predilection. The condition is characterized by burning sensation present over the oral mucosa and tongue, with no definable clinical signs. The etiology for BMS is not clear cut, so does the quality of treating the condition is hampered. The present paper reviews the etiology, pathophysiology, diagnostic criteria’s and treatment modalities in treating BMS which poses as a great challenge for the oral physicians.

scholarly journals Proteomics-Based Identification of Salivary Changes in Patients with Burning Mouth Syndrome

Biology ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 392
Author(s):  
Candela Castillo-Felipe ◽  
Lorena Franco-Martínez ◽  
Asta Tvarijonaviciute ◽  
Pia Lopez-Jornet ◽  
Elsa Lamy
Keyword(s):  
Sleep Disturbances ◽  
Relevant Information ◽  
Burning Mouth Syndrome ◽  
Diagnostic Tools ◽  
Leukocyte Elastase ◽  
Elastase Inhibitor ◽  
Number Of Factors ◽  
Whole Saliva ◽  
Burning Mouth ◽  
As Stress

Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Although a number of factors have been closely related to the appearance of the symptoms, including anxiety, depression, and sleep disturbances, the etiology of BMS remains unclear. Furthermore, currently no objective diagnostic tools exist, making its diagnosis challenging. Therefore, to contribute to the knowledge about BMS etiology and look for objective tools for its diagnosis, the present study was conducted. Thus, the aim of this study was to analyze the proteomic profile of the resting whole saliva of patients with BMS and age and sex-matched controls using two-dimensional electrophoresis. The results showed evidence of changes in saliva at the level of proteins related to important pathways such as stress (sAA), immune system (Ig), and inflammation (leukocyte elastase inhibitor). While some of our findings have been previously described others, such as the deregulation of the coiled-coin domain containing protein 25 in BMS, are presented here for the first time to our knowledge. Thus, saliva provides us with relevant information about BMS pathophysiology and could be considered a suitable biofluid for its study and/or diagnosis.

Exfoliative cytology of the oral mucosa in burning mouth syndrome: a cytomorphological and cytomorphometric analysis

Gerodontology ◽  
2011 ◽  
Vol 28 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Talita Wandeur ◽  
Sérgio Adriane Bezerra de Moura ◽  
Ana Miryam Costa de Medeiros ◽  
Maria Ângela Naval Machado ◽  
Luciana Reis de Azevedo Alanis ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Burning Mouth Syndrome ◽  
Exfoliative Cytology ◽  
Burning Mouth

scholarly journals Is Burning Mouth Syndrome Based on a Physiological Mechanism which Resembles that of Neuropathic Pain?

2019 ◽  
pp. 11-14
Author(s):  
Marisol Reyes Sevilla DDS
Keyword(s):  
Neuropathic Pain ◽  
Oral Mucosa ◽  
Treatment Approach ◽  
Physiological Mechanism ◽  
Burning Mouth Syndrome ◽  
Organic Disease ◽  
Subjective Symptoms ◽  
Burning Pain ◽  
Pain State ◽  
Burning Mouth

Burning mouth syndrome (BMS) is a chronic intraoral pain state that has been described as burning pain, tingling or numbness in the oral mucosa, in the absence of any organic disease. Most often affecting the tongue, anterior palate, and/or lips. The diagnosis of primary BMS is purely clinical and based on patients’ description of typical subjective symptoms as well on the exclusion of any systemic or local factors that may give rise to secondary burning pain sensations within the oral mucosa. Relevant studies links BMS to a peripheral neuropathy and BMS patients have revealed distinct abnormalities within the trigeminofacial large and small fiber systems and the trigeminal brainstem complex. Therefore, treatment approach should involve a multidisciplinary character similar to the treatment for neuropathic pain including factors that might also play a role on the BMS etiology and pathophysiology.

Burning Mouth Syndrome

2013 ◽  
Vol 56 (9) ◽  
pp. 550
Author(s):  
Jae Won Chang ◽  
Chul-Ho Kim
Keyword(s):  
Burning Mouth Syndrome ◽  
Burning Mouth
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