scholarly journals Inner Mongolian Cashmere Goat Secondary Follicle Development Regulation Research Based on mRNA-miRNA Co-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Wenjing Han ◽  
Feng Yang ◽  
Zhihong Wu ◽  
Fuqiang Guo ◽  
Junjie Zhang ◽  
...  
Keyword(s):  
Follicle Development ◽  
Cashmere Goat ◽  
Secondary Follicle ◽  
Development Regulation

Wool follicle development in the New Zealand Romney and N type sheep. II. Follicle population density during foetal development

1958 ◽  
Vol 9 (1) ◽  
pp. 138 ◽  
Author(s):  
SK Stephenson
Keyword(s):  
New Zealand ◽  
Population Density ◽  
Subsequent Development ◽  
The Body ◽  
Limiting Factor ◽  
Follicle Development ◽  
Primary Follicle ◽  
Foetal Development ◽  
Secondary Follicle ◽  
The Face

Quantitative aspects of follicle initiation and development have been studied in a series of N-type and New Zealand Romney foetuses. Density of the follicle population and ratios of secondary to primary follicles were examined on 13 positions of the body which covered the main wool-bearing areas, the face and head, and the limbs. Primary follicle development is initiated first on the head and limbs and throughout subsequent development these regions are most advanced. Primary follicle density reaches a maximum between 75 and 90 days of foetal age, after which it decreases as a result of skin growth. Secondary follicle initiation is more rapid on the wool-bearing areas of the body, and higher ratios of secondary to primary follicles are recorded from these regions. No real differences have been found between N-type and New Zealand Romney foetuses in population density of the different follicle types at any age or in the number of secondary follicles developed per primary follicle. The growth of larger primary fibres and follicles in N-type foetuses is not accompanied by, and does not result from, a lower density of primary follicles. There does not appear to be any marked relation between the decreasing density of primary follicles after 90 days of foetal age and the initiation of secondary follicle anlagen. This fact, and the absence of any differences in the number of secondary anlagen formed per primary follicle in N-types, suggest that crowding in N-types is not a limiting factor in the formation of secondary follicle anlagen.

scholarly journals Red LED light promotes hair follicle development to improve fibre quality in Su line Angora rabbit

2019 ◽  
Author(s):  
Feng Qin ◽  
Jing Wang ◽  
Le Shao ◽  
Xiaoqing Pan ◽  
Jie Yang ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Fibre Diameter ◽  
Follicle Development ◽  
Fibre Quality ◽  
Primary Follicle ◽  
Led Light ◽  
Secondary Follicle ◽  
Red Led ◽  
Wool Yield ◽  
Hair Follicle Development

Abstract Background: Light has crucial roles in animal physiological activities. This study aimed to investigate the effects of different colours of light-emitting diodes (LEDs) on rabbit fibre quality and hair follicle development. 50 three-month-old Su line Angora rabbits were randomly assigned to five groups. Treatment groups were exposed to same intensities of red, green and blue LED light under 16 h light:8 h dark photoperiod regimes. Control groups were exposed to white light and black. The trial spanned 73 days. Results: Results showed that LED colours exerted different effects on wool yield, fibre quality, hormones and hair follicle development. The wool yield of red group was higher than that of white, green and black groups (P<0.05). The shoulder fibre length of red group was higher than that of white and green groups (P<0.05). The coarse fibre diameter of white group was lower than that of green and black groups (P<0.05). The fibre diameter of red group was the lowest and was lower by 13.9% than that of control group (P>0.05). The coarse fibre ratio of green group was higher (13.31%) than that of red group (3.81%, P<0.05). The follicle groups of white, green and black groups consisted of 1 primary follicle associated with 3 or 4 secondary follicle groups and those of blue group consisted of 1 primary follicle associated with 5–10 secondary follicle groups. The follicle of red group consisted of numerous secondary follicles and a few primary follicles. In same magnification, the numbers of follicle groups of white, red, green, blue and black groups were 14.0, 16.5, 10.0, 11.67 and 11.0, respectively. The numbers of follicle groups of red and green groups significantly differed (P<0.05). Serum melatonin (MT) of red group was highest than that of white and green groups (P<0.01), higher than that of black group (P<0.05), serumTriiodothyronine (T 3 ) of red group was higher than that of white and black groups (P<0.05). Conclusions: Thus, the data reveal that red LED light can improve fibre quality, this may be due to red LED light which can enhance the secretion of melatonin to promote hair follicle development .

scholarly journals A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis

2020 ◽  
Author(s):  
Wei Ge ◽  
Wei-Dong Zhang ◽  
Yue-Lang Zhang ◽  
Yu-Jie Zheng ◽  
Fang Li ◽  
...  
Keyword(s):  
Single Cell ◽  
Hair Follicle ◽  
Single Cells ◽  
Cell Lineage ◽  
Hair Follicles ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Cell Fate Decisions ◽  
Molecular Profiles ◽  
Hair Follicle Development

AbstractCashmere, also known as soft gold, is produced from the secondary hair follicles in Cashmere goats and it’s therefore of significance to investigate the molecular profiles during Cashmere goat hair follicle development. However, our current understanding of the machinery underlying Cashmere goat hair follicle remains largely unexplored and researches regarding hair follicle development mainly used the mouse as a research model. To provides comprehensively understanding on the cellular heterogeneity and cell lineage cell fate decisions, we performed single-cell RNA sequencing on 19,705 single cells from induction (embryonic day 60), organogenesis (embryonic day 90) and cytodifferentiation (embryonic day 120) stages of fetus Cashmere goat dorsal skin. Unsupervised clustering analysis identified 16 cell clusters and their corresponding cell types were also unprecedentedly characterized. Based on the lineage inference, we revealed detailed molecular landscape along the dermal and epidermal cell lineage developmental pathways. Notably, by cross-species comparasion of single cell data with murine model, we revelaed conserved programs during dermal condensate fate commitment and the heterochrony development of hair follicle development between mouse and Cashmere goat were also discussed here. Our work here delineate unparalleled molecular profiles of different cell populations during Cashmere goat hair follicle morphogenesis and provide a valuable resource for identifying biomarkers during Cashmere goat hair follicle development.

The effects of exogenous melatonin and prolactin on wool follicle development in ovine foetal skin grafts

1993 ◽  
Vol 44 (5) ◽  
pp. 993 ◽  
Author(s):  
CE McCloghry ◽  
DE Hollis ◽  
A Foldes ◽  
AJ Rintoul ◽  
P Baker ◽  
...  
Keyword(s):  
Nude Mice ◽  
Follicle Development ◽  
Skin Grafts ◽  
Epidermal Thickness ◽  
Exogenous Melatonin ◽  
Merino Sheep ◽  
Secondary Follicle ◽  
Wool Follicle

The fleece of the Merino sheep is composed predominantly of wool fibres grown from secondary wool follicles. This study investigates the effects of melatonin and prolactin on the development of secondarv follicles in grafted ovine foetal skin. Skin from day 85 ovine foetuses was grafted onto nude mice, developed for 40 days and then excised. Mice received either 30 8g prolactin ip mouse-1 day-1 (P), one melatonin implant (Regulin�) sc mouse -1 (M), commencing at grafting or no further treatment (C). Wool follicle density and development were assessed in grafted skin and compared with day 125 control foetal skin. Cuticle structure of graft fibres was also examined and compared with those of day 125 foetuses. Total follicle density and the rate of follicle initiation were reduced in the grafts compared with control foetal skin. Total follicle density did not vary significantly between treatments, but the number of derived secondary follicles was greater in grafts from mice receiving prolactin (group P). Follicles in grafted skin were larger, produced medullated fibres, and were not grouped, in comparison with follicles in the control foetal skin. Epidermal thickness was greater in grafts than in control foetal skin. The cuticle structure of graft fibres from all groups was similar to the control wool fibres. These findings indicate that prolactin, but not melatonin, may be involved in the regulation of derived secondary follicle development.

Skin follicle development in Cheviot × Dorset Horn cross foetuses

1975 ◽  
Vol 84 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Marjorie B. Derbyshire
Keyword(s):  
Follicle Development ◽  
Secondary Follicle ◽  
Skin Samples

SUMMARYSkin samples were used to evaluate the developing skin follicle population of Cheviot × Dorset Horn cross foetuses. The follicle population was studied from the first appearance of skin follicles (55 days' gestation) to the end of gestation. The pattern of development of primary and secondary follicles is described, and compared with the data available for other breeds. The occurrence of secondary follicle branching, previously confirmed only in the Merino, is described, and the ‘prenatal check’, an important feature of follicle development which had not previously been investigated in prenatal studies, is briefly discussed.

scholarly journals Whole-genome sequencing of Chinese native goat offers biological insights into cashmere fiber formation

2021 ◽  
Author(s):  
Hu Han ◽  
Man-Man Yang ◽  
Dan Jiang ◽  
Xing-Ju Zhang ◽  
Qiang Wei ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Association Studies ◽  
Genetic Alterations ◽  
Fiber Formation ◽  
Luciferase Assay ◽  
Follicle Development ◽  
Cashmere Goat ◽  
Genome Wide ◽  
Hair Follicle Development ◽  
Almost All

Cashmere evolved naturally in the goat, and almost all breeds of goat can produce more or less cashmere fibers. However, the genetic alterations underlying cashmere trait selection are still unclear.We sequenced 120 Chinese native goat including two cashmere goat breeds (Ujumain, Chaidamu) and six ordinary goat breeds (Jining Gray, Matou, Guizhou Black, Jintang Black, Yunnan Black Bone, Chengdu Brown). The genome-wide selective sweep of cashmere goat and ordinary goat revealed a novel set of candidate genes as well as pathways, such as Nuclear factor kappa-B and Wnt Signaling pathways. Of them, the LHX2 gene regulating hair follicle development, was evident from the strongest selection signal when comparing the Uhumqin cashmere goat and ordinary goat. Interestingly, we identified a 582bp deletion at 367 kb upstream of LHX2 with higher frequency in cashmere goats and their ancient relatives. This mutation probably rises along the breeding procedures, and is putatively responsible for cashmere production and diameter, as revealed by association studies. Luciferase assay shows that the deletion, which acts as an insulator, restrains the expression of LHX2 by interfering its upstream enhancers.Our study discovers a novel insulator of the LHX2 involved in regulating cashmere production and diameter, which would be beneficial to understanding hair follicle development and regeneration. Our findings also provide new insights into the genetic formation of cashmere, and facilitate subsequent molecular breeding for cashmere goat improvement.

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