scholarly journals Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hadi Samadian ◽  
Sina Zamiri ◽  
Arian Ehterami ◽  
Saeed Farzamfar ◽  
Ahmad Vaez ◽  
...  
Keyword(s):  
Cellulose Acetate ◽  
Ulcer Healing ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
In Vivo Studies

scholarly journals Electrospun cellulose acetate/gelatin nanofibrous wound dressing containing berberine for diabetic foot ulcer healing: in vitro and in vivo studies

2019 ◽  
Author(s):  
Hadi Samadian ◽  
Arian Ehterami ◽  
Saeed Farzamfar ◽  
Ahmad Vaez ◽  
Hossein Khastar ◽  
...  
Keyword(s):  
Cellulose Acetate ◽  
Diabetic Foot ◽  
Wound Dressing ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Biological Properties ◽  
In Vivo Studies ◽  
Vapor Permeability

AbstractFunctional dressing with tailored physicochemical and biological properties is vital for diabetic foot ulcer (DFU) treatment. Our main objective in the current study was to fabricate Cellulose Acetate/Gelatin (CA/Gel) electrospun nanofibrous mat loaded with berberine (Beri) as the DFU dressing. The results demonstrated that the diameter of the nanofibers was around 502 nm, the tensile strength, contact angle, porosity, water vapor permeability, and water uptake ratio of CA/Gel nanofibers were around 2.83 MPa, 58.07, 78.17 %, 11.23 mg/cm2 hr, and 12.78 respectively, while these values for CA/Gel/Beri nanofibers were 2.69 ± 0.05 MPa, 56.93 ± 1, 76.17 ± 0.76 %, 10.17 ± 0.21 mg/cm2 hr, 14.37 ± 0.42 respectively. The bacterial evaluations demonstrated that the dressings are an excellent barrier against bacterial penetration with potent antibacterial activity. The animal studies depicted that the collagen density and angiogenesis score in the CA/Gel/Beri treated group were 88.8±6.7 % and 19.8±3.8, respectively. These findings implied that the incorporation of berberine did not compromise the physical properties of dressing, while improving the biological activates. In conclusion, our findings implied that the prepared mat is a proper wound dressing for DFU management and treatment.

Valsartan solid lipid nanoparticles integrated hydrogel: A challenging repurposed use in the treatment of diabetic foot ulcer, in-vitro/in-vivo experimental study

2021 ◽  
Vol 592 ◽  
pp. 120091
Author(s):  
Noha S. El-Salamouni ◽  
Mennatallah A. Gowayed ◽  
Nevine L. Seiffein ◽  
Rehab A. Abdel- Moneim ◽  
Maher A. Kamel ◽  
...  
Keyword(s):  
Experimental Study ◽  
Diabetic Foot ◽  
Solid Lipid Nanoparticles ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Lipid Nanoparticles ◽  
Solid Lipid

scholarly journals The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
Ka-Kit Tsang ◽  
Enid Wai-Yung Kwong ◽  
Kevin Y. Woo ◽  
Tony Shing-Shun To ◽  
Joanne Wai-Yee Chung ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Animal Studies ◽  
Chronic Wounds ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
In Vivo Studies ◽  
Resistant Bacteria ◽  
Manuka Honey ◽  
Anti Inflammatory

Honey and silver have been used since ancient times for treating wounds. Their widespread clinical application has attracted attention in light of the increasing prevalence of antibiotic-resistant bacteria. While there have been a number of studies exploring the anti-inflammatory and antibacterial effects of manuka honey and nanocrystalline silver, their advantages and limitations with regard to the treatment of chronic wounds remain a subject of debate. The aim of this paper is to examine the evidence on the use of nanocrystalline silver and manuka honey for treating diabetic foot ulcers through a critical and comprehensive review of in vitro studies, animal studies, and in vivo studies. The findings from the in vitro and animal studies suggest that both agents have effective antibacterial actions. Their anti-inflammatory action and related impact on wound healing are unclear. Besides, there is no evidence to suggest that any topical agent is more effective for use in treating diabetic foot ulcer. Overall, high-quality, clinical human studies supported by findings from the molecular science on the use of manuka honey or nanocrystalline silver are lacking. There is a need for rigorously designed human clinical studies on the subject to fill this knowledge gap and guide clinical practice.

Intermittent cycles of remote ischemic preconditioning augment diabetic foot ulcer healing

2015 ◽  
Vol 23 (2) ◽  
pp. 191-196 ◽  
Author(s):  
Gad Shaked ◽  
David Czeiger ◽  
Anwar Abu Arar ◽  
Tiberiu Katz ◽  
Ilana Harman-Boehm ◽  
...  
Keyword(s):  
Ischemic Preconditioning ◽  
Ulcer Healing ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Remote Ischemic Preconditioning

scholarly journals Health literacy and diabetic foot ulcer healing

2015 ◽  
Vol 23 (3) ◽  
pp. 299-301 ◽  
Author(s):  
David J. Margolis ◽  
Michelle Hampton ◽  
Ole Hoffstad ◽  
D. Scot Malay ◽  
Stephen Thom
Keyword(s):  
Health Literacy ◽  
Ulcer Healing ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer

scholarly journals A Pilot Randomized, Controlled Study of Nanocrystalline Silver, Manuka Honey, and Conventional Dressing in Healing Diabetic Foot Ulcer

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Ka-Kit Tsang ◽  
Enid Wai-Yung Kwong ◽  
Tony Shing-Shun To ◽  
Joanne Wai-Yee Chung ◽  
Thomas Kwok-Shing Wong
Keyword(s):  
Ulcer Healing ◽  
Diabetic Foot ◽  
Reduction Rate ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Size Reduction ◽  
Controlled Study ◽  
Manuka Honey ◽  
Ulcer Size ◽  
Randomized Controlled

Nanocrystalline silver (nAg) and Manuka honey (MH) dressing have increasing popularity for treating diabetic foot ulcer (DFU). This study was an open-label randomized controlled trial with three parallel groups’ design in examining the preliminary effectiveness of nAg against MH and conventional dressing in healing DFU in terms of ulcer healing, ulcer infection, and inflammation. 31 participants (11 in the nAg group, 10 in the MH group, and 10 in the convention group) diagnosed with type 2 diabetes were enrolled. Wound cleaning, debridement, and topical dressing application were performed according to the group allocation in each visit at weeks 1, 2, 3, 4, 6, 8, 10, and 12. The results found that the proportions of complete ulcer healing were 81.8%, 50%, and 40% in the nAg, MH, and conventional groups, respectively. The ulcer size reduction rate was potentially higher in the nAg group (97.45%) than the MH group (86.21%) and the conventional group (75.17%). In bacteriology, nAg showed a greater rate of microorganism reduction although it was not significant. To conclude, nAg alginate was potentially superior to MH and conventional dressing in healing diabetic foot ulcer in terms of ulcer size reduction rate.

Continuous diffusion of oxygen improves diabetic foot ulcer healing when compared with a placebo control: a randomised, double-blind, multicentre study

2018 ◽  
Vol 27 (Sup9) ◽  
pp. S30-S45 ◽  
Author(s):  
Mark Q. Niederauer ◽  
Joel E. Michalek ◽  
Qianqian Liu ◽  
Klearchos K. Papas ◽  
Lawrence A. Lavery ◽  
...  
Keyword(s):  
Multicentre Study ◽  
Ulcer Healing ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Placebo Control ◽  
Double Blind

scholarly journals Efficacy of Cellular Therapy for Diabetic Foot Ulcer

2017 ◽  
Vol 26 (12) ◽  
pp. 1931-1939 ◽  
Author(s):  
Ye Zhang ◽  
Hong Deng ◽  
Zhouping Tang
Keyword(s):  
Ulcer Healing ◽  
Diabetic Foot ◽  
Cellular Therapy ◽  
Meta Analysis ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Mean Difference ◽  
Cochrane Library ◽  
Transcutaneous Oxygen ◽  
Randomized Controlled

Diabetes mellitus is a widely spread chronic disease with growing incidence worldwide, and diabetic foot ulcer is one of the most serious complications of diabetes. Cellular therapy has shown promise in the management of diabetic foot ulcer in many preclinical experiments and clinical researches. Here, we performed a meta-analysis to evaluate the efficacy and safety of cellular therapy in the management of diabetic foot ulcer. We systematically searched PubMed, MEDLINE, EMBASE, and Cochrane Library databases from inception to May 2017 for randomized controlled trials assessing the efficacy of cellular therapy in diabetic foot ulcer, and a meta-analysis was conducted. A total of 6 randomized controlled clinical trials involving 241 individuals were included in this meta-analysis. The results suggested that cellular therapy could help accelerating the healing of diabetic foot ulcer, presented as higher ankle-brachial index (mean difference = 0.17, 95% confidence interval [CI] = 0.11 to 0.23), higher transcutaneous oxygen pressure (standardized mean difference [SMD] = 1.43; 95% CI, 1.09– to 1.78), higher ulcer healing rate (relative risk [RR] = 1.78; 95% CI, 1.41 to 2.25), higher amputation-free survival (RR = 1.25; 95% CI, 1.11 to 1.40), and lower scale of pain (SMD = −1.69; 95% CI, −2.05 to −1.33). Furthermore, cellular therapy seemed to be safe, with no serious complications and low risk of short-term slight complications. Cellular therapy could accelerate the rate of diabetic foot ulcer healing and may be more efficient than standard therapy for diabetic foot treatment.

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