scholarly journals A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Grace MacDonald ◽  
Andrea Sitlinger ◽  
Michael A. Deal ◽  
Erik D. Hanson ◽  
Stephanie Ferraro ◽  
...  
Keyword(s):  
Older Adults ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Nk Cell ◽  
Interval Training ◽  
Lymphocytic Leukemia ◽  
Muscle Endurance ◽  
High Intensity Interval Training ◽  
Treatment Naïve ◽  
High Intensity Interval

AbstractChronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to improving CLL patients’ physical fitness and immune functions may be participation in a structured exercise program. The aims of this pilot study were to examine physical and immunological changes, and feasibility of a 12-week high-intensity interval training (HIIT) combined with muscle endurance-based resistance training on older adults with treatment naïve CLL. We enrolled eighteen participants with CLL aged 64.9 ± 9.1 years and assigned them to groups depending on distance lived from our fitness center. Ten participants (4 M/6F) completed HIIT and six participants (4 M/2F) completed a non-exercising control group (Controls). HIIT consisted of three 30-min treadmill sessions/week plus two concurrent 30-min strength training sessions/week. Physical and immunological outcomes included aerobic capacity, muscle strength and endurance, and natural killer (NK) cell recognition and killing of tumor cells. We confirmed feasibility if > 70% of HIIT participants completed > 75% of prescribed sessions and prescribed minutes, and if > 80% of high-intensity intervals were at a heart rate corresponding to at least 80% of peak aerobic capacity (VO2peak). Results are presented as Hedge’s G effect sizes (g), with 0.2, 0.5 and 0.8 representing small, medium and large effects, respectively. Following HIIT, leg strength (g = 2.52), chest strength (g = 1.15) and seated row strength (g = 3.07) were 35.4%, 56.1% and 39.5% higher than Controls, respectively, while aerobic capacity was 3.8% lower (g = 0.49) than Controls. Similarly, following HIIT, in vitro NK-cell cytolytic activity against the K562 cell line (g = 1.43), OSU-CLL cell line (g = 0.95), and autologous B-cells (g = 1.30) were 20.3%, 3.0% and 14.6% higher than Controls, respectively. Feasibility was achieved, with HIIT completing 5.0 ± 0.2 sessions/week and 99 ± 3.6% of the prescribed minutes/week at heart rates corresponding to 89 ± 2.8% of VO2peak. We demonstrate that 12-weeks of supervised HIIT combined with muscle endurance-based resistance training is feasible, and that high adherence and compliance are associated with large effects on muscle strength and immune function in older adults with treatment naïve CLL.Trial registration: NCT04950452.

scholarly journals A Pilot Study of High-Intensity Interval Training in Older Adults with Treatment Naive Chronic Lymphocytic Leukemia.

2021 ◽  
Author(s):  
Grace A. MacDonald ◽  
Andrea Sitlinger ◽  
Michael A. Deal ◽  
Erik D. Hanson ◽  
Stephanie Ferraro ◽  
...  
Keyword(s):  
Older Adults ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Nk Cell ◽  
Interval Training ◽  
Lymphocytic Leukemia ◽  
Muscle Endurance ◽  
High Intensity Interval Training ◽  
Treatment Naïve ◽  
High Intensity Interval

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the USA, affecting predominantly older adults. CLL is characterized by low physical fitness, reduced immunity, and increased risk of secondary malignancies and infections. One approach to improving physical fitness and immune functions is participation in a structured exercise program. The aims of this pilot study were to determine the feasibility and outcomes of 12-weeks of high-intensity interval training (HIIT) combined with muscle endurance-based resistance training on older adults with treatment naive CLL. We enrolled eighteen participants with CLL aged 64.9 (9.1) years and assigned them to groups depending on distance lived from our fitness center. Ten participants (4M/6F) completed HIIT and six participants (4M/2F) completed a non-exercising control group (Controls). HIIT consisted of three 30-minute treadmill sessions/week plus two concurrent 30-minute strength training sessions/week. We confirmed feasibility if >70% of HIIT participants completed >75% of prescribed sessions and prescribed minutes, and if >80% of high-intensity intervals were at a heart rate corresponding to 80% of aerobic capacity [139 (19) bpm]. Secondary outcomes included aerobic capacity, muscle strength and endurance, and natural killer (NK) cell recognition and killing of tumor cells. Results are presented as Hedge's G effect sizes (g), with 0.2, 0.5 and 0.8 representing small, medium and large effects, respectively. Feasibility was achieved, with HIIT completing 5.0 (0.2) sessions/week and 99 (3.6)% of prescribed minutes/week at 142 (19)bpm. Following HIIT, leg strength (g=2.52), chest strength (g=1.15) and seated row strength (g=3.07) were 35.4%, 56.1% and 39.5% higher, respectively, while aerobic capacity was 3.8% lower (g=0.49) than changes for Controls. Similarly, following HIIT, in vitro NK-cell cytolytic activity against the K562 cell line (g=1.43), OSU-CLL cell line (g=0.95), and autologous B-cells (g=1.30) were 20.3%, 3.0% and 14.6% higher, respectively, than changes for Controls. We demonstrate that 12-weeks of HIIT combined with muscle endurance-based resistance training is feasible in older adults with untreated CLL and that HIIT has a large effect on muscle strength and important components of immune function.

scholarly journals High-Intensity Interval Training in Older Adults With Treatment Naive Chronic Lymphocytic Leukemia

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 459-459
Author(s):  
David Bartlett ◽  
Grace MacDonald ◽  
Mike Deal ◽  
Erik Hanson ◽  
Carl Pieper ◽  
...  
Keyword(s):  
Older Adults ◽  
Chronic Lymphocytic Leukemia ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Interval Training ◽  
Lymphocytic Leukemia ◽  
Effect Sizes ◽  
High Intensity Interval Training ◽  
Treatment Naïve ◽  
High Intensity Interval

Abstract Chronic lymphocytic leukemia (CLL) is the most common leukemia, affecting predominantly older adults. Treatment naïve patients (CLLtn) with low physical fitness have poor survival following commencement of treatment. CLLtn is characterized by inadequate immune functions, increased risk of secondary malignancies and infections. The aims of this study were to determine the feasibility and preliminary effects of 12-weeks of high-intensity interval training (HIIT) on CLLtn patients. We enrolled eighteen CLLtn patients (64.9±9.1yrs.). Eleven (5M/6F) were allocated to HIIT and seven (4M/3F) to the control group (CON). HIIT consisted of three 30-minute treadmill sessions/week plus two 30-minute strength training sessions/week. Feasibility was confirmed if >70% of HIIT participants completed >75% of prescribed sessions and prescribed minutes, and if >80% of high-intensity intervals were at a heart rate corresponding to 80% of aerobic capacity (139±19 bpm). Results are presented as mean±SD and effect sizes (d), with 0.2, 0.5 and 0.8 representing small, medium and large effect sizes, respectively. Feasibility was achieved, with HIIT completing 5.0±0.2 sessions/week and 99±3.6% of prescribed minutes/week at 142±19 bpm. No adverse safety events were observed. Compared to CON, HIIT increased leg (d=2.602), chest (d=1.285), and seated row (d=3.323) strength, while aerobic capacity difference between groups was d=0.431. Compared to CON, HIIT increased in vitro natural killer immune cell cytolytic activity against K562 (d=1.586) and OSU-CLL (d=0.917) cancer cell lines, and autologous CLL cells (d=1.362). HIIT is safe and feasible in older adults with CLLtn. Preliminary effects suggest that HIIT increases muscle strength and important components of immune function.

Comparison of High-Intensity Interval Training to Moderate-Intensity Continuous Training in Older Adults: A Systematic Review

2020 ◽  
Vol 28 (5) ◽  
pp. 798-807
Author(s):  
Christopher J. Keating ◽  
Juan Á. Párraga Montilla ◽  
Pedro Á. Latorre Román ◽  
Rafael Moreno del Castillo
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Cardiorespiratory Fitness ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Female Population ◽  
High Intensity Interval

High-intensity interval training (HIIT) is emerging as a safe and effective means to combat chronic diseases. The objective of this work was to perform a systematic review of the effect of HIIT interventions in an aging population. Three electronic databases were searched for randomized trials comparing the effect of HIIT and moderate-intensity continuous training in older adults. After a thorough screening process, 15 articles were identified as meeting the inclusion criteria. All studies expressed a comparable or superior effect of HIIT in cardiorespiratory fitness measures. No studies reported a lessened effect of HIIT in comparison with moderate-intensity continuous training. This systematic review demonstrates that HIIT is a useful exercise regimen, which can be used in older adults to increase cardiorespiratory fitness. More research is needed to determine the effects of HIIT in an aging, predominately female population.

scholarly journals Salutary effects of high-intensity interval training in persons with elevated cardiovascular risk

F1000Research ◽  
2016 ◽  
Vol 5 ◽  
pp. 2254 ◽  
Author(s):  
Jerome L. Fleg
Keyword(s):  
Cardiovascular Risk ◽  
Aerobic Capacity ◽  
High Intensity ◽  
Interval Training ◽  
Aerobic Exercise Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Continuous Training ◽  
Beneficial Effects ◽  
High Intensity Interval

Although moderate-intensity continuous training (MICT) has been the traditional model for aerobic exercise training for over four decades, a growing body of literature has demonstrated equal if not greater improvement in aerobic capacity and similar beneficial effects on body composition, glucose metabolism, blood pressure, and quality of life from high-intensity interval training (HIIT). An advantage of HIIT over MICT is the shorter time required to perform the same amount of energy expenditure. The current brief review summarizes the effects of HIIT on peak aerobic capacity and cardiovascular risk factors in healthy adults and those with various cardiovascular diseases, including coronary artery disease, chronic heart failure, and post heart transplantation.

scholarly journals Increased Brain Glucose Uptake After 12 Weeks of Aerobic High-Intensity Interval Training in Young and Older Adults

2017 ◽  
Vol 103 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Matthew M Robinson ◽  
Val J Lowe ◽  
K Sreekumaran Nair
Keyword(s):  
Older Adults ◽  
Glucose Uptake ◽  
High Intensity ◽  
Brain Metabolism ◽  
Control Period ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Brain Glucose ◽  
High Intensity Interval ◽  
The Impact

Abstract Context Aerobic exercise training can increase brain volume and blood flow, but the impact on brain metabolism is less known. Objective We determined whether high-intensity interval training (HIIT) increases brain metabolism by measuring brain glucose uptake in younger and older adults. Design Brain glucose uptake was measured before and after HIIT or a sedentary (SED) control period within a larger exercise study. Setting Study procedures were performed at the Mayo Clinic in Rochester, MN. Participants Participants were younger (18 to 30 years) or older (65 to 80 years) SED adults who were free of major medical conditions. Group sizes were 15 for HIIT (nine younger and six older) and 12 for SED (six younger and six older). Intervention Participants completed 12 weeks of HIIT or SED. HIIT was 3 days per week of 4 × 4 minute intervals at over 90% of peak aerobic capacity (VO2peak) with 2 days per week of treadmill walking at 70% VO2peak. Main Outcome Measures Resting brain glucose uptake was measured using 18F-fluorodeoxyglucose positron emission tomography scans at baseline and at week 12. Scans were performed at 96 hours after exercise. VO2peak was measured by indirect calorimetry. Results Glucose uptake increased significantly in the parietal-temporal and caudate regions after HIIT compared with SED. The gains with HIIT were not observed in all brain regions. VO2peak was increased for all participants after HIIT and did not change with SED. Conclusion We demonstrate that brain glucose metabolism increased after 12 weeks of HIIT in adults in regions where it is reduced in Alzheimer’s disease.

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