scholarly journals Age affects procedural paired-associates learning in the grey mouse lemur (Microcebus murinus)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Daniel Schmidtke
Keyword(s):  
Nonhuman Primate ◽  
Animal Studies ◽  
Brain Aging ◽  
Mouse Lemur ◽  
Microcebus Murinus ◽  
Primate Model ◽  
Aging Research ◽  
Paired Associates ◽  
Age Related ◽  
Grey Mouse Lemur

AbstractThe ability to associate memorized objects with their location in space gradually declines during normal aging and can drastically be affected by neurodegenerative diseases. This study investigates object-location paired-associates learning (PAL) in the grey mouse lemur (Microcebus murinus), a nonhuman primate model of brain aging. Touchscreen-based testing of 6 young adults (1–5 years) and 6 old adults (> 7 years) in the procedural rodent dPAL-task revealed significant age-related performance decline, evident in group differences in the percentage of correct decision during learning and the number of sessions needed to reach a predefined criterion. Response pattern analyses suggest decreased susceptibility to relative stimulus-position biases in young animals, facilitating PAL. Additional data from a subset of “overtrained” individuals (n = 7) and challenge sessions using a modified protocol (sPAL) further suggest that learning criteria routinely used in animal studies on PAL can underestimate the endpoint at which a stable performance is reached and that more conservative criteria are needed to improve construct validity of the task. To conclude, this is the first report of an age effect on dPAL and corroborates the role of mouse lemurs as valuable natural nonhuman primate models in aging research.

scholarly journals Touchscreen-Based Cognitive Tasks Reveal Age-Related Impairment in a Primate Aging Model, the Grey Mouse Lemur (Microcebus murinus)

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109393 ◽  
Author(s):  
Marine Joly ◽  
Sandra Ammersdörfer ◽  
Daniel Schmidtke ◽  
Elke Zimmermann
Keyword(s):  
Mouse Lemur ◽  
Cognitive Tasks ◽  
Microcebus Murinus ◽  
Aging Model ◽  
Age Related ◽  
Grey Mouse Lemur

scholarly journals Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function

2019 ◽  
Vol 116 (52) ◽  
pp. 26247-26254 ◽  
Author(s):  
Daniel T. Gray ◽  
Carol A. Barnes
Keyword(s):  
Nonhuman Primate ◽  
Brain Aging ◽  
Sensory Function ◽  
Aging Brain ◽  
Primate Research ◽  
Primate Model ◽  
Aging Research ◽  
Macaque Monkeys ◽  
Processing Abilities ◽  
Sensory Decline

The use of animal models in brain aging research has led to numerous fundamental insights into the neurobiological processes that underlie changes in brain function associated with normative aging. Macaque monkeys have become the predominant nonhuman primate model system in brain aging research due to their striking similarities to humans in their behavioral capacities, sensory processing abilities, and brain architecture. Recent public concern about nonhuman primate research has made it imperative to attempt to clearly articulate the potential benefits to human health that this model enables. The present review will highlight how nonhuman primates provide a critical bridge between experiments conducted in rodents and development of therapeutics for humans. Several studies discussed here exemplify how nonhuman primate research has enriched our understanding of cognitive and sensory decline in the aging brain, as well as how this work has been important for translating mechanistic implications derived from experiments conducted in rodents to human brain aging research.

scholarly journals Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2498
Author(s):  
Jan B. Stöckl ◽  
Nina Schmid ◽  
Florian Flenkenthaler ◽  
Charis Drummer ◽  
Rüdiger Behr ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Human Testis ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Morphological Alterations ◽  
Age Related ◽  
Cell Niche ◽  
Peritubular Cells

Age-related changes in the human testis may include morphological alterations, disturbed steroidogenesis, and impaired spermatogenesis. However, the specific impact of cell age remains poorly understood and difficult to assess. Testicular peritubular cells fulfill essential functions, including sperm transport, contributions to the spermatogonial stem cell niche, and paracrine interactions within the testis. To study their role in age-associated decline of testicular functions, we performed comprehensive proteome and secretome analyses of repeatedly passaged peritubular cells from Callithrix jacchus. This nonhuman primate model better reflects the human testicular biology than rodents and further gives access to young donors unavailable from humans. Among 5095 identified proteins, 583 were differentially abundant between samples with low and high passage numbers. The alterations indicate a reduced ability of senescent peritubular cells to contract and secrete proteins, as well as disturbances in nuclear factor (NF)-κB signaling and a reduced capacity to handle reactive oxygen species. Since this in vitro model may not exactly mirror all molecular aspects of in vivo aging, we investigated the proteomes and secretomes of testicular peritubular cells from young and old donors. Even though the age-related alterations at the protein level were less pronounced, we found evidence for impaired protein secretion, altered NF-κB signaling, and reduced contractility of these in vivo aged peritubular cells.

P1-006: Donepezil prevented the cognitive impairment induced by sleep deprivation in a nonhuman primate, the grey mouse lemur

2013 ◽  
Vol 9 ◽  
pp. P155-P155
Author(s):  
Anisur Rahman ◽  
Fabien Pifferi ◽  
Yves Lamberty ◽  
Esther Schenker ◽  
Regis Bordet ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Sleep Deprivation ◽  
Nonhuman Primate ◽  
Mouse Lemur ◽  
Grey Mouse Lemur

A nonhuman primate model of age-related bone loss: a longitudinal study in male and premenopausal female rhesus monkeys

Bone ◽  
2001 ◽  
Vol 28 (3) ◽  
pp. 295-302 ◽  
Author(s):  
A Black ◽  
E.M Tilmont ◽  
A.M Handy ◽  
W.W Scott ◽  
S.A Shapses ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Bone Loss ◽  
Nonhuman Primate ◽  
Rhesus Monkeys ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Age Related ◽  
Female Rhesus ◽  
Premenopausal Female
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