Quantification of triglyceride levels in fresh human blood by terahertz time-domain spectroscopy

AbstractWe conducted a pilot clinical study to investigate ex vivo fresh human blood from 93 patients with coronary heart disease (CHD). The results indicated that terahertz (THz) time-domain spectroscopy (TDS) can be used to quantify triglyceride (TG) levels in human blood. Based on the TG concentrations and corresponding THz absorption coefficients, the Pearson correlation analysis demonstrated that the THz absorption coefficients have a significant negative linear correlation with TG concentration. Comparisons between the THz measurements at 0.2 THz and an automatic biochemical analyzer were performed using an additional 20 blood samples, and the results confirmed that the relative error was less than 15%. Our ex vivo human blood study indicates that the THz technique can be used to assess blood TG levels in clinical diagnostic practice.

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Characteristic fingerprint spectrum of neurotransmitter norepinephrine with broadband terahertz time-domain spectroscopy

The Analyst ◽

10.1039/c8an02079e ◽

2019 ◽

Vol 144 (8) ◽

pp. 2504-2510 ◽

Cited By ~ 7

Author(s):

Zhongjie Zhu ◽

Chao Cheng ◽

Chao Chang ◽

Guanhua Ren ◽

Jianbing Zhang ◽

...

Keyword(s):

Absorption Spectrum ◽

Time Domain ◽

Vibrational Modes ◽

Terahertz Time Domain Spectroscopy ◽

Time Domain Spectroscopy ◽

Thz Absorption ◽

Broadband Terahertz

A broadband THz absorption spectrum of NE corresponds to specific vibrational modes.

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Terahertz Time-Domain Spectroscopy of Human Blood

IEEE Transactions on Terahertz Science and Technology ◽

10.1109/tthz.2013.2267414 ◽

2013 ◽

Vol 3 (4) ◽

pp. 363-367 ◽

Cited By ~ 16

Author(s):

Caroline B. Reid ◽

George Reese ◽

Adam P. Gibson ◽

Vincent P. Wallace

Keyword(s):

Human Blood ◽

Time Domain ◽

Terahertz Time Domain Spectroscopy ◽

Time Domain Spectroscopy

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Transformation and dehydration kinetics of methylene blue hydrates detected by terahertz time-domain spectroscopy

RSC Advances ◽

10.1039/c7ra07118c ◽

2017 ◽

Vol 7 (66) ◽

pp. 41667-41674 ◽

Cited By ~ 7

Author(s):

Shihan Yan ◽

Hua Zhang ◽

Zhongbo Yang ◽

Mingjie Tang ◽

Mingkun Zhang ◽

...

Keyword(s):

Methylene Blue ◽

Time Domain ◽

Terahertz Spectroscopy ◽

Dehydration Kinetics ◽

Terahertz Time Domain Spectroscopy ◽

Time Domain Spectroscopy ◽

Thz Absorption ◽

Kinetics Of ◽

Absorption Features ◽

Crystalline Hydrates

Three methylene blue crystalline hydrates were identified by terahertz spectroscopy according to their different THz absorption features.

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Ex vivo sensing and imaging of corneal scar tissues using terahertz time domain spectroscopy

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2021.119667 ◽

2021 ◽

Vol 255 ◽

pp. 119667

Author(s):

Lin Ke ◽

Qing Yang Steve Wu ◽

Nan Zhang ◽

Hong Wei Liu ◽

Erica Pei Wen Teo ◽

...

Keyword(s):

Time Domain ◽

Ex Vivo ◽

Terahertz Time Domain Spectroscopy ◽

Time Domain Spectroscopy ◽

Corneal Scar

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Terahertz Time-domain Spectroscopy as a Novel Tool for Crystallographic Analysis in Cellulose: Cellulose I to Cellulose Ii, Tracing the Structural Changes Under Chemical Treatment

10.21203/rs.3.rs-864353/v1 ◽

2021 ◽

Author(s):

Han Wang ◽

Hiroki Kataoka ◽

Satoru Tsuchikawa ◽

Tetsuya Inagaki

Keyword(s):

Absorption Coefficient ◽

Time Domain ◽

Structural Changes ◽

Crystalline Lattice ◽

Thz Radiation ◽

Cellulose Ii ◽

Cellulose I ◽

Terahertz Time Domain Spectroscopy ◽

Time Domain Spectroscopy ◽

Thz Absorption

Abstract Terahertz time-domain spectroscopy (THz-TDS) has expanded possibilities in cellulose crystallography research, as THz radiation detects most intermolecular vibrations and responds to the phonons of crystalline lattices. In this study, we traced the transformation of the cellulose crystalline lattice from cellulose I to cellulose II by THz-TDS and X-ray powder diffraction. Cellulose II was obtained by treating cellulose I with NaOH of different concentrations (0 wt%–20 wt%, at 2 wt% intervals). The THz absorption coefficient spectra of cellulose II showed three characteristic peaks (at 1.32 THz, 1.76 THz, and 2.77 THz). The THz absorption coefficient spectra of cellulose II treated with 20-wt% NaOH and cellulose I without NaOH treatment were fitted by a seventh-order Fourier series. Thus, the THz absorption coefficient spectra of samples treated with NaOH of other concentrations could be considered a combination of these two fitted profiles of cellulose I and cellulose II, multiplied by different coefficients. Furthermore, the coefficients could reflect the relative contents of cellulose I and cellulose II in the samples.

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Wavelength Selection Method Based on Differential Evolution for Precise Quantitative Analysis Using Terahertz Time-Domain Spectroscopy

Applied Spectroscopy ◽

10.1177/0003702817722367 ◽

2017 ◽

Vol 71 (12) ◽

pp. 2653-2660 ◽

Cited By ~ 1

Author(s):

Zhi Li ◽

Weidong Chen ◽

Feiyu Lian ◽

Hongyi Ge ◽

Aihong Guan

Keyword(s):

Quantitative Analysis ◽

Differential Evolution ◽

Time Domain ◽

Selection Method ◽

Wavelength Selection ◽

Terahertz Time Domain Spectroscopy ◽

Noise Sources ◽

Time Domain Spectroscopy ◽

Amino Acid Mixtures ◽

Thz Absorption

Quantitative analysis of component mixtures is an important application of terahertz time-domain spectroscopy (THz-TDS) and has attracted broad interest in recent research. Although the accuracy of quantitative analysis using THz-TDS is affected by a host of factors, wavelength selection from the sample’s THz absorption spectrum is the most crucial component. The raw spectrum consists of signals from the sample and scattering and other random disturbances that can critically influence the quantitative accuracy. For precise quantitative analysis using THz-TDS, the signal from the sample needs to be retained while the scattering and other noise sources are eliminated. In this paper, a novel wavelength selection method based on differential evolution (DE) is investigated. By performing quantitative experiments on a series of binary amino acid mixtures using THz-TDS, we demonstrate the efficacy of the DE-based wavelength selection method, which yields an error rate below 5%.

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Terahertz spectroscopy and imaging for gastric cancer diagnosis

Journal of Spectral Imaging ◽

10.1255/jsi.2020.a2 ◽

2020 ◽

Author(s):

Faustino Wahaia ◽

Irmantas Kašalynas ◽

Linas Minkevičius ◽

Catia Carvalho Silva ◽

Andrzej Urbanowicz ◽

...

Keyword(s):

Time Domain ◽

Terahertz Spectroscopy ◽

Human Cancer ◽

Terahertz Waves ◽

Terahertz Time Domain Spectroscopy ◽

Tissue Samples ◽

Time Domain Spectroscopy ◽

Affected Tissue ◽

Gastrointestinal Tissue ◽

Thz Absorption

Terahertz waves are sensitive to differences in biological tissue hydration, we present promising results regarding the feasibility of applying this with terahertz time-domain spectroscopy and imaging for early detection of cancer through the characterisation of human gastrointestinal tissue with cancer-affected regions. To do that, healthy (normal) and carcinoma-affected gastric tissue samples at different stages were measured using transmission terahertz time-domain spectroscopy in the frequency range of 0.15–2.00 THz. Absorption coefficients and refractive index spectra of both normal and carcinoma-affected tissue were extracted and analysed. The results confirm that the techniques may be powerful tools to perform qualitative, early diagnosis of human cancer.

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