scholarly journals Maternal body mass index in pregnancy and mental disorders in adult offspring: a record linkage study in Aberdeen, Scotland

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marius Lahti-Pulkkinen ◽  
Katri Räikkönen ◽  
Sohinee Bhattacharya ◽  
Rebecca M. Reynolds
Keyword(s):  
Body Mass Index ◽  
Mental Disorders ◽  
Body Mass ◽  
Maternal Obesity ◽  
Severe Obesity ◽  
Maternal Body Mass Index ◽  
Adult Offspring ◽  
Maternal Body ◽  
Maternal Bmi ◽  
In Pregnancy

AbstractMaternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother–child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950–1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996–2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950–1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01–3.00)]. In offspring born 1975–1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08–2.38) substance use (HR 1.91; 95% CI 1.03–3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40–5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.

scholarly journals Maternal Body Mass Index during Pregnancy and Offspring Neurocognitive Development

2013 ◽  
Vol 6 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Wendy Y Craig ◽  
Glenn E Palomaki ◽  
Louis M Neveux ◽  
James E Haddow
Keyword(s):  
Body Mass Index ◽  
Regression Analysis ◽  
Body Mass ◽  
Inverse Relationship ◽  
Maternal Obesity ◽  
Maternal Body Mass Index ◽  
Second Trimester ◽  
Maternal Body ◽  
Neurocognitive Development ◽  
Maternal Bmi

Background: This hypothesis generating study explores second trimester maternal body mass index (BMI) during pregnancy and offspring neurocognitive development. Methods: Mothers and offspring served as controls in two earlier studies: 101 children at age two years and 118 children at age eight years. Results Frequency of maternal BMI ≥30 kg/m 2 increased from 10% in 1987-1990 to 30% in 2004-2006 ( P < 0.001); the socioeconomic gradient became more pronounced. At age two, one or more BSID-III (Bayley Scales of Infant Development, 3rd Edition) scores <85 were more frequent with higher maternal BMI ( P = 0.029); regression analysis suggested an inverse relationship between language scores and BMI ( P = 0.054). Among eight-year-olds, one or more WISC-III (Wechsler Intelligence Scale for Children, 3rd edition) scores <85 increased with maternal BMI ( P = 0.017); regression analysis showed an inverse relationship between performance subscale IQ score and BMI ( P = 0.023). Conclusion: Second trimester maternal obesity may be an independent risk factor for some aspects of children's neurocognitive development. Further study is indicated.

scholarly journals The influence of maternal body mass index on oxytocin and prostaglandin signaling in pregnancy

2022 ◽  
Vol 226 (1) ◽  
pp. S655-S656
Author(s):  
Sydney Lammers ◽  
Douglas Kniss ◽  
Niharika Patel ◽  
Kyra Peczkowski ◽  
Mahmoud Abdelwahab ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Maternal Body Mass Index ◽  
Maternal Body ◽  
In Pregnancy

Effect of Maternal Body Mass Index and Amniotic Fluid Index on the Accuracy of Sonographic Estimation of Fetal Weight in Late Gestation

2018 ◽  
Vol 35 (13) ◽  
pp. 1235-1240 ◽  
Author(s):  
Burton Rochelson ◽  
Leah Stork ◽  
Stephanie Augustine ◽  
Meir Greenberg ◽  
Cristina Sison ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Amniotic Fluid ◽  
Body Mass ◽  
Fetal Weight ◽  
Maternal Body Mass Index ◽  
Amniotic Fluid Index ◽  
Maternal Body ◽  
Significant Difference ◽  
Substantial Error ◽  
Maternal Bmi

Objective The objective of this study was to determine the effect, if any, of maternal body mass index (BMI) and amniotic fluid index (AFI) on the accuracy of sonographic estimated fetal weight (EFW) at 40 to 42 weeks' gestation. Methods This was a retrospective cohort study of singleton gestations with ultrasound performed at 40 to 42 weeks from 2010 to 2013. In this study, patients with documented BMI and sonographic EFW and AFI, concurrently, within 7 days of delivery were included. Chronic medical conditions and fetal anomalies were excluded from this study. The primary variable of interest was the rate of substantial error in EFW, defined as absolute percentage error (APE) >10%. Results A total of 1,000 pregnancies were included. Overall, the APE was 6.0 ± 4.5% and the rate of substantial error was 17.4% (n = 174). There was no significant difference in APE or rate of substantial error between BMI groups. In the final multivariable logistic regression model, the rate of substantial error was increased in women with oligohydramnios (OR 1.79; 95% CI: 1.10–2.92). Furthermore, oligohydramnios was significantly more likely to overestimate EFW while polyhydramnios was more likely to underestimate EFW. Maternal BMI did not affect the accuracy of sonographic EFW. Conclusion Sonographic EFW may be affected by extremes of AFI in the postdates period. Maternal BMI does not affect EFW accuracy at 40 to 42 weeks.

Exploratory Study of the Relationship Between Maternal Body Mass Index and Spontaneous Fetal Movements

2016 ◽  
Author(s):  
Wei Ning (Will) Jiang
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Interrater Reliability ◽  
Well Being ◽  
Normal Weight ◽  
Maternal Body Mass Index ◽  
Body Movements ◽  
Maternal Body ◽  
Fetal Movements ◽  
Maternal Bmi

Maternal body mass index (BMI) has been reported to be associated with the number of fetal body movements and the duration of fetal breathing movements in hypertensive pregnant women (Brown et al., 2008). However, whether a relationship exists in pregnancies classified as overweight or normal weight but not complicated by hypertension is unknown and the focus of this study. Forty-five maternal-fetal pairs (normotensive, normal weight=15; normotensive, overweight=15; hypertensive=15) who had participated in a study of fetal behavior which included a 20 min real-time ultrasound scan observation of fetal movements were randomly selected from the laboratory archival database. Gestational age at testing ranged from 33-39 weeks [M(SD)= 36.2 (1.4) weeks]. All infants were delivered healthy at term. Video-recordings of the ultrasound scans were scored for the number of fetal body movements (interrater reliability r=.97) and the cumulative duration of breathing (interrater reliability r=.94) movements. The number of fetal body movements differed between groups, F(2,38)=3.19, p=0.05, with fetuses of overweight mothers moving less frequently than those of normal weight mothers (M=9.7 vs 15.5, respectively). Maternal BMI prior to pregnancy, r=-0.43, p<0.01, and at time of observation, r=-0.44, p<0.01, was associated with the number of fetal body movements, but not with duration of breathing movements. As BMI increased, the number of fetal body movements decreased. It was concluded that maternal BMI may affect the number of spontaneous fetal movements. A prospective study is necessary to determine whether BMI should be considered when using body movement counts to assess well-being and/or neurodevelopment.

Stereology of human myometrium in pregnancy: influence of maternal body mass index and age

2013 ◽  
Vol 208 (4) ◽  
pp. 324.e1-324.e6 ◽  
Author(s):  
Eva M. Sweeney ◽  
Denis J. Crankshaw ◽  
Yvonne O'Brien ◽  
Peter Dockery ◽  
John J. Morrison
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Human Myometrium ◽  
Maternal Body Mass Index ◽  
Maternal Body ◽  
In Pregnancy

Effect of Maternal Body Mass Index on the Retinal Microvasculature in Pregnancy

2012 ◽  
Vol 120 (3) ◽  
pp. 627-635 ◽  
Author(s):  
Ling-Jun Li ◽  
M. Kamran Ikram ◽  
Carol Yim-Lui Cheung ◽  
Yung-Seng Lee ◽  
Lin-Jun Lee ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Maternal Body Mass Index ◽  
Maternal Body ◽  
Retinal Microvasculature ◽  
In Pregnancy

scholarly journals Maternal body mass index, neonatal lung function and respiratory symptoms in childhood

2015 ◽  
Vol 46 (5) ◽  
pp. 1342-1349 ◽  
Author(s):  
Jacobien B. Eising ◽  
Cuno S.P.M. Uiterwaal ◽  
Cornelis K. van der Ent
Keyword(s):  
Body Mass Index ◽  
Lung Function ◽  
Body Mass ◽  
Maternal Obesity ◽  
First Year ◽  
Maternal Body Mass Index ◽  
Maternal Body ◽  
Increased Risk ◽  
Neonatal Lung ◽  
First Year Of Life

Recent studies have shown that maternal obesity is associated with increased risk of wheezing in the offspring. We assessed whether impaired neonatal lung function could explain this association.We measured neonatal lung function in 2606 children of our prospective birth cohort. Information about daily symptoms of wheezing was obtained using questionnaires. Consultations and prescriptions for wheezing illnesses were derived from general practitioner patient files.Higher maternal body mass index (BMI) was associated with increased risk of wheezing in the first year of life and more consultations and prescriptions for wheezing illnesses until the age of 5 years. Lung function could partially explain the association with wheezing in the first year of life. Adding respiratory resistance to the model decreased the incidence rate ratio from 1.023 (95% CI 1.008–1.039) to 1.015 (95% CI 0.998–1.032). Anthropometrics of the 5-year-olds largely explained the association with consultations. Intermediates or confounders could not explain the association with prescriptions.There is an association between higher maternal BMI and increased risk of wheezing illnesses. In the first year of life, it is largely explained by an impaired lung function in early life, especially in children of nonatopic mothers. At the age of 5 years, infant lung function is of minor influence in this association.

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