scholarly journals The effect of galvanization and potassium iodide iontophoresis of the throat and larynx on thyroid parameters: a randomized controlled trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jolanta Zwolińska ◽  
Barbara Augustyn ◽  
Katarzyna Baj ◽  
Jadwiga Krukowska
Keyword(s):  
Randomized Controlled Trial ◽  
Potassium Iodide ◽  
Controlled Trial ◽  
Thyroid Ultrasonography ◽  
Randomized Controlled ◽  
Parallel Group ◽  
Thyroid Hormone Levels ◽  
Double Blinded

AbstractFew studies have assessed the application and side effects of potassium iodide (KI) iontophoresis. Using a double-blinded randomized controlled trial with a 1:1 parallel-group, we investigated the effect of galvanization and the KI iontophoresis in the throat and larynx on three thyroid parameters. A total of 50 healthy volunteers with normal TSH, FT3, and FT4 levels and lacking focal changes in the thyroid ultrasonography were subjected to 10 electrotherapy treatments. The TSH, FT3, and FT4 levels were determined prior to the 10 electrotherapeutic treatments (T1), 2-weeks after treatment (T2) and 6-months after treatment (T3). At T2 and T3, both groups had normal levels of TSH, FT3, and FT4. Regarding the change of TSH, FT3, and FT4 levels between T1 vs. T2 and T1 vs. T3, no significant differences between the galvanization and iontophoresis groups were found. However, both groups had lower levels of all three hormones at T3. Together, these data indicate that KI iontophoresis does not affect thyroid hormone levels in the short- nor long-term. Additional follow-up studies with larger groups are required to better confirm the safety of galvanization and iontophoresis procedures in the pharynx and larynx.Trial registration ClinicalTrials.gov (NCT04013308; URL: www.clinicaltrials.gov). Day of first registration 09/07/2019.

scholarly journals Electrotherapy Treatments Performed in the Area of the Throat and Larynx and the Level of TSH, FT3 and FT4 Hormones: A Randomized Controlled Trial

2021 ◽  
Author(s):  
Jolanta Zwolińska ◽  
Barbara Augustyn ◽  
Katarzyna Baj ◽  
Jadwiga Krukowska
Keyword(s):  
Randomized Controlled Trial ◽  
Potassium Iodide ◽  
Controlled Trial ◽  
Hormone Levels ◽  
Randomized Controlled ◽  
Parallel Group ◽  
Completion Test ◽  
Short And Long Term ◽  
Double Blinded ◽  
The University

Abstract No current studies are available on application and side effects of potassium iodide iontophoresis. This study assessed the potassium iodide iontophoresis effect in the throat and larynx area on TSH, FT3 and FT4 hormone levels. Double-blinded randomized controlled trial with 1:1 parallel-group was conducted at the University of Rzeszow, Poland. A total of 50 healthy volunteers with normal TSH, FT3, FT4 levels without focal changes in the thyroid ultrasonography were subjected to 10 electrotherapy treatments (galvanization and iontophoresis groups). TSH, FT3, FT4 levels were determined before 10 treatments (test 1), 2 weeks after their completion (test 2) and after 6 months (test 3). In tests 2 and 3, both groups had normal levels of TSH, FT3, and FT4. No statistically significant differences between the galvanization and iontophoresis groups were found in terms of change of TSH, FT3, FT4 levels between tests 1 vs. 2 and 1 vs. 3. Both groups had lower levels of all measured parameters in test 3. Potassium iodide iontophoresis does not affect thyroid hormone levels in the short and long term. It is advisable to continue the follow-up study with larger groups to confirm the safety of electrotherapy procedures in the pharynx and larynx area.

scholarly journals Endothelial Dysfunction, Atherosclerosis, and Increase of von Willebrand Factor and Factor VIII: A Randomized Controlled Trial in Swine

2021 ◽  
Author(s):  
Ferdows Atiq ◽  
Jens van de Wouw ◽  
Oana Sorop ◽  
Ilkka Heinonen ◽  
Moniek P. M. de Maat ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Randomized Controlled Trial ◽  
Endothelial Dysfunction ◽  
Controlled Trial ◽  
Short Term ◽  
Randomized Controlled ◽  
Von Willebrand ◽  
Willebrand Factor

AbstractIt is well known that high von Willebrand factor (VWF) and factor VIII (FVIII) levels are associated with an increased risk of cardiovascular disease. It is still debated whether VWF and FVIII are biomarkers of endothelial dysfunction and atherosclerosis or whether they have a direct causative role. Therefore, we aimed to unravel the pathophysiological pathways of increased VWF and FVIII levels associated with cardiovascular risk factors. First, we performed a randomized controlled trial in 34 Göttingen miniswine. Diabetes mellitus (DM) was induced with streptozotocin and hypercholesterolemia (HC) via a high-fat diet in 18 swine (DM + HC), while 16 healthy swine served as controls. After 5 months of follow-up, FVIII activity (FVIII:C) was significantly higher in DM + HC swine (5.85 IU/mL [5.00–6.81]) compared with controls (4.57 [3.76–5.40], p = 0.010), whereas VWF antigen (VWF:Ag) was similar (respectively 0.34 IU/mL [0.28–0.39] vs. 0.34 [0.31–0.38], p = 0.644). DM + HC swine had no endothelial dysfunction or atherosclerosis during this short-term follow-up. Subsequently, we performed a long-term (15 months) longitudinal cohort study in 10 Landrace–Yorkshire swine, in five of which HC and in five combined DM + HC were induced. VWF:Ag was higher at 15 months compared with 9 months in HC (0.37 [0.32–0.42] vs. 0.27 [0.23–0.40], p = 0.042) and DM + HC (0.33 [0.32–0.37] vs. 0.25 [0.24–0.33], p = 0.042). Both long-term groups had endothelial dysfunction compared with controls and atherosclerosis after 15 months. In conclusion, short-term hyperglycemia and dyslipidemia increase FVIII, independent of VWF. Long-term DM and HC increase VWF via endothelial dysfunction and atherosclerosis. Therefore, VWF seems to be a biomarker for advanced cardiovascular disease.

scholarly journals Long-Term Effects of Resistance Exercise Training on Cognition and Brain Volume in Older Women: Results from a Randomized Controlled Trial

2015 ◽  
Vol 21 (10) ◽  
pp. 745-756 ◽  
Author(s):  
John R. Best ◽  
Bryan K. Chiu ◽  
Chun Liang Hsu ◽  
Lindsay S. Nagamatsu ◽  
Teresa Liu-Ambrose
Keyword(s):  
Randomized Controlled Trial ◽  
White Matter ◽  
Resistance Training ◽  
Exercise Training ◽  
Older Women ◽  
Controlled Trial ◽  
Resistance Exercise Training ◽  
Randomized Controlled

AbstractAerobic exercise training has been shown to attenuate cognitive decline and reduce brain atrophy with advancing age. The extent to which resistance exercise training improves cognition and prevents brain atrophy is less known, and few studies include long-term follow-up cognitive and neuroimaging assessments. We report data from a randomized controlled trial of 155 older women, who engaged in 52 weeks of resistance training (either once- or twice-weekly) or balance-and-toning (twice-weekly). Executive functioning and memory were assessed at baseline, 1-year follow-up (i.e., immediately post-intervention), and 2-year follow-up. A subset underwent structural magnetic resonance imaging scans at those time points. At 2-year follow-up, both frequencies of resistance training promoted executive function compared to balance-and-toning (standardized difference [d]=.31–.48). Additionally, twice-weekly resistance training promoted memory (d=.45), reduced cortical white matter atrophy (d=.45), and increased peak muscle power (d=.27) at 2-year follow-up relative to balance-and-toning. These effects were independent of one another. These findings suggest resistance training may have a long-term impact on cognition and white matter volume in older women. (JINS, 2015,21, 745–756)

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